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Breadcrumb Erik Sahai Sahai lab Tumour Cell Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Co-culture of cancer cells (darker cells) with stromal fibroblasts (lighter cells) with a signalling molecule shown in green speckles. Toggle to view hero caption PublicationsYear published2023 (1)2021 (3)2020 (1)2019 (2)2015 (1) Facet Year publishedResearch topicsCell Biology (8)Computational & Systems Biology (8)Imaging (8)Model Organisms (8)Tumour Biology (8)Chemical Biology & High Throughput (4)Genetics & Genomics (4)Genome Integrity & Repair (4)Human Biology & Physiology (3)Signalling & Oncogenes (3)Biochemistry & Proteomics (1)Cell Cycle & Chromosomes (1)Developmental Biology (1)Gene Expression (1)Immunology (1)Infectious Disease (1)Metabolism (1)Microfabrication & Bioengineering (1)Neurosciences (1)Stem Cells (1)Synthetic Biology (1) (-)Structural Biology & Biophysics (8) Facet Research topicsPublication typeJournal article (8)Primary research (7)Method (1) Facet Publication typeJournalNature Ecology and Evolution (2)eLife (1)Journal of the Royal Society Interface (1)Life Science Alliance (1)Nature Materials (1)PLoS Computational Biology (1)The Lancet (1) Facet Journal Publications Displaying 1 - 8 of 8Last updated : 24 April 2024 03:29 Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma Authors (12) Takuya KatoRob Jenkins Stefanie Derzsi Melda TozluogluToni Rullan IriarteSteven Hooper[...] Holly JoyceXiao Fu Selvam ThavarajPaul BatesErik Sahai eLife Published 9 March 2023 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Selection of metastasis competent subclones in the tumour interior Authors (27) Yue ZhaoXiao Fu Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Paul BatesCharles SwantonSamra Turajlic TRACERx Renal Consortium Kevin Litchfield Nature Ecology and Evolution Published 1 July 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsFull details A FIJI macro for quantifying pattern in extracellular matrix Authors (11)Esther WershofDanielle ParkDavid BarryRob JenkinsToni Rullan Iriarte Anna WilkinsKarin Schlegelmilch Ioannis RoxanisKurt AndersonPaul BatesErik Sahai Life Science Alliance Published 1 March 2021 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions Authors (9)Danielle ParkEsther WershofStefan Boeing Anna LabernadieRob Jenkins Samantha George Xavier TrepatPaul BatesErik Sahai Nature Materials Published 1 February 2020 Crick labs/ facilitiesErik SahaiPaul BatesBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Matrix feedback enables diverse higher-order patterning of the extracellular matrix Authors (6)Esther WershofDanielle ParkRob JenkinsDavid BarryErik SahaiPaul Bates PLoS Computational Biology Published 28 October 2019 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyBioinformatics and BiostatisticsFull details Cost-benefit analysis of the mechanisms that enable migrating cells to sustain motility upon changes in matrix environments Authors (4) Melda Tozluoglu Yanlan MaoPaul BatesErik Sahai Journal of the Royal Society Interface Published 6 May 2015 Crick labsErik SahaiPaul BatesFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma Authors (12) Takuya KatoRob Jenkins Stefanie Derzsi Melda TozluogluToni Rullan IriarteSteven Hooper[...] Holly JoyceXiao Fu Selvam ThavarajPaul BatesErik Sahai eLife Published 9 March 2023 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
Selection of metastasis competent subclones in the tumour interior Authors (27) Yue ZhaoXiao Fu Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Paul BatesCharles SwantonSamra Turajlic TRACERx Renal Consortium Kevin Litchfield Nature Ecology and Evolution Published 1 July 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsFull details
A FIJI macro for quantifying pattern in extracellular matrix Authors (11)Esther WershofDanielle ParkDavid BarryRob JenkinsToni Rullan Iriarte Anna WilkinsKarin Schlegelmilch Ioannis RoxanisKurt AndersonPaul BatesErik Sahai Life Science Alliance Published 1 March 2021 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions Authors (9)Danielle ParkEsther WershofStefan Boeing Anna LabernadieRob Jenkins Samantha George Xavier TrepatPaul BatesErik Sahai Nature Materials Published 1 February 2020 Crick labs/ facilitiesErik SahaiPaul BatesBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Matrix feedback enables diverse higher-order patterning of the extracellular matrix Authors (6)Esther WershofDanielle ParkRob JenkinsDavid BarryErik SahaiPaul Bates PLoS Computational Biology Published 28 October 2019 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyBioinformatics and BiostatisticsFull details
Cost-benefit analysis of the mechanisms that enable migrating cells to sustain motility upon changes in matrix environments Authors (4) Melda Tozluoglu Yanlan MaoPaul BatesErik Sahai Journal of the Royal Society Interface Published 6 May 2015 Crick labsErik SahaiPaul BatesFull details