Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Erik Sahai Sahai lab Tumour Cell Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Co-culture of cancer cells (darker cells) with stromal fibroblasts (lighter cells) with a signalling molecule shown in green speckles. Toggle to view hero caption PublicationsYear published (-)2013 (7) Facet Year publishedPublication typeJournal article (7)Primary research (6)Method (1) Facet Publication typeJournalNature Cell Biology (2)Breast Cancer Research (1)Cancer Research (1)Current Protocols in Cell Biology (1)Journal of Pathology (1)Oncogene (1) Facet Journal Publications Displaying 1 - 7 of 7Last updated : 18 April 2024 03:43 Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions Authors (6) Melda Tozluoğlu Alexander L TournierRob JenkinsSteven HooperPaul BatesErik Sahai Nature Cell Biology Published 1 July 2013 Crick labsErik SahaiPaul BatesFull details Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts Authors (11) Fernando Calvo Nil Ege Araceli Grande-GarciaSteven HooperRob Jenkins Shahid I Chaudhry Kevin Harrington Peter Williamson Emad Moeendarbary Guillaume CharrasErik Sahai Nature Cell Biology Published 1 June 2013 Crick labsErik SahaiFull details Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes Authors (16) Raghu Kadaba Hanna Birke Jun WangSteven Hooper Claudia D Andl Francesco Di Maggio[...] Anil K RustgiErik Sahai Claude Chelala Peter Sasieni Hemant M Kocher Journal of Pathology Published 1 May 2013 Crick labsErik SahaiFull details Arkadia regulates tumor metastasis by modulation of the TGF-β pathway Authors (7) Marco A Briones-Orta Laurence Levy Chris D MadsenDebipriya Das Yigit ErkerErik SahaiCaroline Hill Cancer Research Published 15 March 2013 Crick labsErik SahaiCaroline HillFull details Imaging tumor cell movement in vivo Authors (6) David Entenberg Dmitriy Kedrin Jeffrey WyckoffErik Sahai John Condeelis Jeffrey E Segall Current Protocols in Cell Biology Published 1 March 2013 Crick labsErik SahaiFull details Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts Authors (6) SI ChaudhrySteven HooperEmma Nye P Williamson K HarringtonErik Sahai Oncogene Published 7 February 2013 Crick labs/ facilitiesErik SahaiExperimental HistopathologyFull details Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer Authors (87) Suzanne A Eccles Eric O Aboagye Simak Ali Annie S Anderson Jo Armes Fedor Berditchevski[...] Rosemary A Walker Christine J Watson Kaye J Williams Leonie S Young Alastair M Thompson Breast Cancer Research Published 1 January 2013 Crick labsErik SahaiFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions Authors (6) Melda Tozluoğlu Alexander L TournierRob JenkinsSteven HooperPaul BatesErik Sahai Nature Cell Biology Published 1 July 2013 Crick labsErik SahaiPaul BatesFull details
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts Authors (11) Fernando Calvo Nil Ege Araceli Grande-GarciaSteven HooperRob Jenkins Shahid I Chaudhry Kevin Harrington Peter Williamson Emad Moeendarbary Guillaume CharrasErik Sahai Nature Cell Biology Published 1 June 2013 Crick labsErik SahaiFull details
Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes Authors (16) Raghu Kadaba Hanna Birke Jun WangSteven Hooper Claudia D Andl Francesco Di Maggio[...] Anil K RustgiErik Sahai Claude Chelala Peter Sasieni Hemant M Kocher Journal of Pathology Published 1 May 2013 Crick labsErik SahaiFull details
Arkadia regulates tumor metastasis by modulation of the TGF-β pathway Authors (7) Marco A Briones-Orta Laurence Levy Chris D MadsenDebipriya Das Yigit ErkerErik SahaiCaroline Hill Cancer Research Published 15 March 2013 Crick labsErik SahaiCaroline HillFull details
Imaging tumor cell movement in vivo Authors (6) David Entenberg Dmitriy Kedrin Jeffrey WyckoffErik Sahai John Condeelis Jeffrey E Segall Current Protocols in Cell Biology Published 1 March 2013 Crick labsErik SahaiFull details
Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts Authors (6) SI ChaudhrySteven HooperEmma Nye P Williamson K HarringtonErik Sahai Oncogene Published 7 February 2013 Crick labs/ facilitiesErik SahaiExperimental HistopathologyFull details
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer Authors (87) Suzanne A Eccles Eric O Aboagye Simak Ali Annie S Anderson Jo Armes Fedor Berditchevski[...] Rosemary A Walker Christine J Watson Kaye J Williams Leonie S Young Alastair M Thompson Breast Cancer Research Published 1 January 2013 Crick labsErik SahaiFull details