Publications

CRISPR-Cas9-mediated upregulation of utrophin ameliorates Duchenne muscular dystrophy

Authors (13)

Maëlle Ralu
Simon Guiraud
Sumitava Dastidar
Paola Galbiati
Emilia Sadaoui
Fetta Mazed
[...]
Isabelle Richard
Kamel Mamchaoui
Giuseppe Ronzitti
Francesco Saverio Tedesco
Mario Amendola

Molecular Therapy

Published 24 March 2026

Crick labs

Francesco Saverio Tedesco

Full details

Genetic landscape and diagnostic outcomes of UK patients With congenital myopathies and muscular dystrophies over a 10-Year period

Authors (14)

Gianpaolo Cicala
Jo Mccauley
Rahul Phadke
Juliane Mueller
Stephanie Ann Robb
Adnan Y Manzur
[...]
Francesco Saverio Tedesco
Rachael A Mein
Cheryl Walsh
Francesco Muntoni
Anna Sarkozy

Neurology: Genetics

Published 1 April 2026

Crick labs

Francesco Saverio Tedesco

Full details

Imaging-guided platform for real-time intervention in complex in vitro models

Preprint

Authors (15)

Andrea Serio
Sudeep Joshi
Carmen Moreno-Gonzalez
Pacharaporn Suklai
Eugenia Carraro
Colin Ratcliffe
[...]
Thomas Kavanagh
Simon Ameer-beg
Albane Imbert
Erik Sahai
Francesco Saverio Tedesco

Research Square

Published 18 August 2025

Crick labs/ facilities

Full details

Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Preprint

Authors (12)

Daniel Moore
Heather B Steele-Stallard
Luca Pinton
Valentina Lionello
Lucia Rossi
Arta Aghaeipour Dehkaei
[...]
Cherry Tsz Yan Wong
Angela Clara-Hwang
Gisèle Bonne
Peter S Zammit
Francesco Saverio Tedesco

bioRxiv

Published 23 June 2025

Crick labs/ facilities

Full details

VISIBLE: An imaging-driven system for sampling, biofabrication, and manipulation of complex biological models

Preprint

Authors (14)

Sudeep Joshi
Carmen Moreno Gonzalez
Pacharaporn Suklai
Eugenia Carraro
Colin Ratcliffe
Giulia Boezio
[...]
Simon Ameer-beg
Albane Imbert
Erik Sahai
Francesco Saverio Tedesco
Andrea Serio

bioRxiv

Published 17 June 2025

Crick labs/ facilities

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Metabolic remodeling in hiPSC-derived myofibers carrying the m.3243A>G mutation

Authors (14)

Gabriel E Valdebenito
Anitta R Chacko
Chih-Yao Chung
Preethi Sheshadri
Haoyu Chi
Benjamin O'Callaghan
[...]
Valle Morales
Katiuscia Bianchi
Francesco Saverio Tedesco
Robert DS Pitceathly
Michael R Duchen

Stem Cell Reports

Published 8 April 2025

Crick labs

Francesco Saverio Tedesco

Full details

Generation of a human induced pluripotent stem cell line (CRICKi021-A) from a patient with Ullrich congenital muscular dystrophy carrying a pathogenic mutation in the COL6A1 gene

Authors (5)

Yunsong Jiang
Liani Devito
Francesco Muntoni
Lyn Healy
Francesco Saverio Tedesco

Stem Cell Research

Published 1 March 2025

Crick labs/ facilities

Full details

Ammonia transporter RhBG initiates downstream signaling and functional responses by activating NFκB

Authors (20)

Saurabh Mishra
Nicole Welch
Shashi Shekhar Singh
Khuraijam Dhanachandra Singh
Annette Bellar
Avinash Kumar
[...]
Francesco Saverio Tedesco
George A Truskey
I David Weiner
Sadashiva S Karnik
Srinivasan Dasarathy

Proceedings of the National Academy of Sciences of the United States of America

Published 30 July 2024

Crick labs

Francesco Saverio Tedesco

Full details

Low-cost, versatile, and highly reproducible microfabrication pipeline to generate 3D-printed customised cell culture devices with complex designs

Authors (18)

Cathleen Hagemann
Matthew CD Bailey
Eugenia Carraro
Ksenia S Stankevich
Valentina Lionello
Noreen Khokhar
[...]
Mads S Bergholt
Christopher D Spicer
Albane Imbert
Francesco Saverio Tedesco
Andrea Serio

PLOS Biology

Published 13 March 2024

Crick labs/ facilities

Full details

Generation of an MTM1-mutant iPSC line (CRICKi008-A) from an individual with X-linked myotubular myopathy (XLMTM)

Authors (5)

Liani Devito
Valentina Lionello
Francesco Muntoni
Francesco Saverio Tedesco
Lyn Healy

Stem Cell Research

Published 1 June 2023

Crick labs/ facilities

Full details

3D human induced pluripotent stem cell-derived bioengineered skeletal muscles for tissue, disease and therapy modeling

Authors (14)

Luca Pinton
Moustafa Khedr
Valentina Lionello
Shilpita Sarcar
Sara M Maffioletti
Sumitava Dastidar
[...]
Anne Bigot
John R Counsell
Andreia Sofia Bernardo
Peter S Zammit
Francesco Saverio Tedesco

Nature Protocols

Published 1 April 2023

Crick labs

Francesco Saverio Tedesco

Full details

Mesoangioblasts at 20: From the embryonic aorta to the patient bed

Authors (42)

Giulio Cossu
Rossana Tonlorenzi
Silvia Brunelli
Maurilio Sampaolesi
Graziella Messina
Emanuele Azzoni
[...]
Raffaella Scardigli
Dario Sirabella
Francesco Saverio Tedesco
Yvan Torrente
Gonzalo Ugarte

Frontiers in Genetics

Published 4 January 2023

Crick labs

Francesco Saverio Tedesco

Full details

Assessing and enhancing migration of human myogenic progenitors using directed iPS cell differentiation and advanced tissue modelling

Authors (10)

SungWoo Choi
Giulia Ferrari
Louise A Moyle
Kirsty Mackinlay
Naira Naouar
Salma Jalal
Sara Benedetti
Christine Wells
Francesco Muntoni
Francesco Saverio Tedesco

EMBO Molecular Medicine

Published 10 October 2022

Crick labs/ facilities

Full details

Bioengineering human skeletal muscle models: Recent advances, current challenges and future perspectives

Authors (5)

Yunsong Jiang
Tugce Torun
Sara M Maffioletti
Andrea Serio
Francesco Saverio Tedesco

Experimental Cell Research

Published 15 July 2022

Crick labs

Full details

Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy

Authors (19)

Mary Chesshyre
Deborah Ridout
Yasumasa Hashimoto
Yoko Ookubo
Silvia Torelli
Kate Maresh
[...]
Mariacristina Scoto
Giovanni Baranello
Adnan Manzur
Yoshitsugu Aoki
Francesco Muntoni

Journal of Cachexia, Sarcopenia and Muscle

Published 1 April 2022

Crick labs

Francesco Saverio Tedesco

Full details

Dystrophin deficiency affects human astrocyte properties and response to damage

Authors (10)

Jenny Lange
Olivia Gillham
Reem Alkharji
Simon Eaton
Giulia Ferrari
Monika Madej
Michael Flower
Francesco Saverio Tedesco
Francesco Muntoni
Patrizia Ferretti

Glia

Published 1 March 2022

Crick labs

Francesco Saverio Tedesco

Full details

The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies

Authors (22)

Nicolas Vignier
Maria Chatzifrangkeskou
Luca Pinton
Hugo Wioland
Thibaut Marais
Mégane Lemaitre
[...]
Guillaume Romet-Lemonne
Howard J Worman
Francesco Saverio Tedesco
Antoine Jégou
Antoine Muchir

Cell Reports

Published 24 August 2021

Crick labs

Francesco Saverio Tedesco

Full details

Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond

Authors (3)

Salma Jalal
Sumitava Dastidar
Francesco Saverio Tedesco

Current Opinion in Cell Biology

Published 1 December 2021

Crick labs

Francesco Saverio Tedesco

Full details

DLL4 and PDGF-BB regulate migration of human iPSC-derived skeletal myogenic progenitors

Preprint

Authors (8)

Giulia Ferrari
SungWoo Choi
Louise A Moyle
Kirsty Mackinlay
Naira Naouar
Christine Wells
Francesco Muntoni
Francesco Saverio Tedesco

bioRxiv

Published 28 February 2021

Crick labs

Francesco Saverio Tedesco

Full details

Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling

Authors (22)

Yasuhiro Kazuki
Narumi Uno
Satoshi Abe
Naoyo Kajitani
Kanako Kazuki
Yuwna Yakura
[...]
Shin-ichiro Takayanagi
Atsushi Kunisato
Shin Kaneko
Mitsuo Oshimura
Kazuma Tomizuka

Molecular Therapy : Nucleic Acids

Published 5 March 2021

Crick labs

Francesco Saverio Tedesco

Full details

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Publications

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CRISPR-Cas9-mediated upregulation of utrophin ameliorates Duchenne muscular dystrophy

Genetic landscape and diagnostic outcomes of UK patients With congenital myopathies and muscular dystrophies over a 10-Year period

Imaging-guided platform for real-time intervention in complex in vitro models

Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

VISIBLE: An imaging-driven system for sampling, biofabrication, and manipulation of complex biological models

Metabolic remodeling in hiPSC-derived myofibers carrying the m.3243A>G mutation

Generation of a human induced pluripotent stem cell line (CRICKi021-A) from a patient with Ullrich congenital muscular dystrophy carrying a pathogenic mutation in the COL6A1 gene

Ammonia transporter RhBG initiates downstream signaling and functional responses by activating NFκB

Low-cost, versatile, and highly reproducible microfabrication pipeline to generate 3D-printed customised cell culture devices with complex designs

Generation of an MTM1-mutant iPSC line (CRICKi008-A) from an individual with X-linked myotubular myopathy (XLMTM)

3D human induced pluripotent stem cell-derived bioengineered skeletal muscles for tissue, disease and therapy modeling

Mesoangioblasts at 20: From the embryonic aorta to the patient bed

Assessing and enhancing migration of human myogenic progenitors using directed iPS cell differentiation and advanced tissue modelling

Bioengineering human skeletal muscle models: Recent advances, current challenges and future perspectives

Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy

Dystrophin deficiency affects human astrocyte properties and response to damage

The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies

Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond

DLL4 and PDGF-BB regulate migration of human iPSC-derived skeletal myogenic progenitors

Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling

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