Publications

Bumetanide induces post-traumatic microglia-interneuron contact to promote neurogenesis and recovery

Authors (13)

Marine Tessier
Marta Saez Garcia
Emmanuelle Goubert
Edith Blasco
Amandine Consumi
Benoit Dehapiot
[...]
Jerome Laurin
Francois Guillemot
Christian A Hübner
Christophe Pellegrino
Claudio Rivera

Brain

Published 21 April 2023

Crick labs

Francois Guillemot

Full details

Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation

Authors (12)

Genes and Development

Published 1 March 2023

Crick labs/ facilities

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A mouse model with a frameshift mutation in the nuclear factor I/X (NFIX) gene has phenotypic features of Marshall‐Smith syndrome

Authors (28)

Kreepa G Kooblall
Mark Stevenson
Michelle Stewart
Lachlan Harris
Oressia Zalucki
Hannah Dewhurst
[...]
Michael Piper
Sara Wells
Lydia Teboul
Raoul C Hennekam
Rajesh V Thakker

JBMR Plus

Published 14 March 2023

Crick labs/ facilities

Full details

Fluorescence-activated nuclei negative sorting of neurons combined with single nuclei RNA sequencing to study the hippocampal neurogenic niche

Authors (5)

Thomas Kerloch
Tjaša Lepko
Kirill Shkura
Francois Guillemot
Sébastien Gillotin

Journal of Visualized Experiments

Published 20 October 2022

Crick labs

Francois Guillemot

Full details

Editorial: Transcription and chromatin regulators in neurodevelopmental disorders

Authors (4)

Debbie LC van den Berg
Julian Ik-Tsen Heng
Alessandro Sessa
Cristina Dias

Frontiers in Neuroscience

Published 16 September 2022

Crick labs

Francois Guillemot

Full details

DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential

Authors (17)

Developmental Cell

Published 22 August 2022

Crick labs/ facilities

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The relationship between epigenetic age and the hallmarks of ageing in human cells

Authors (12)

Sylwia Kabacik
Donna Lowe
Leonie Fransen
Martin Leonard
Siew-Lan Ang
Christopher Whiteman
[...]
Howard Cohen
Sarah Felton
Radhika Bali
Steve Horvath
Ken Raj

Nature Aging

Published 1 June 2022

Crick labs

Francois Guillemot

Full details

Understanding astrocyte differentiation: Clinical relevance, technical challenges, and new opportunities in the omics era

Authors (2)

WIREs Mechanisms of Disease

Published 1 September 2022

Crick labs

Francois Guillemot

Full details

The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis

Authors (17)

Thomas Kerloch
Fanny Farrugia
Lou Bouit
Marlène Maître
Geoffrey Terral
Muriel Koehl
[...]
Delphine Gonzales
David Perrais
Francois Guillemot
Djoher Nora Abrous
Emilie Pacary

Molecular Psychiatry

Published 1 December 2021

Crick labs/ facilities

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Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation

Authors (7)

Development

Published 15 October 2021

Crick labs/ facilities

Full details

Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

Authors (9)

Michael Lattke
Robert Goldstone
James Ellis
Stefan Boeing
Jerónimo Jurado-Arjona
Nicolás Marichal
James Macrae
Benedikt Berninger
Francois Guillemot

Nature Communications

Published 15 July 2021

Crick labs/ facilities

Full details

Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior

Authors (12)

Lorenza Magno
Zeinab Asgarian
Valentina Pendolino
Theodora Velona
Albert Mackintosh
Flora Lee
[...]
Celine Zimmer
Francois Guillemot
Mark Farrant
Beverley Clark
Nicoletta Kessaris

Cell Reports

Published 15 June 2021

Crick labs

Francois Guillemot

Full details

Identifying cellular signalling molecules in developmental disorders of the brain: Evidence from focal cortical dysplasia and tuberous sclerosis

Authors (17)

Yao-Feng Li
Fatma Scerif
Simon R Picker
Tom J Stone
Jessica C Pickles
Dale A Moulding
[...]
Darren Hargrave
Francois Guillemot
Simon M Paine
Shireena A Yasin
Thomas S Jacques

Neuropathology and Applied Neurobiology

Published 1 October 2021

Crick labs

Francois Guillemot

Full details

Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice

Authors (28)

Naofumi Ito
M Asrafuzzaman Riyadh
Shah Adil Ishtiyaq Ahmad
Satoko Hattori
Yonehiro Kanemura
Hiroshi Kiyonari
[...]
Yoshiko Takahashi
Francois Guillemot
Tsuyoshi Miyakawa
Kazunobu Sawamoto
Kunimasa Ohta

Science Translational Medicine

Published 31 March 2021

Crick labs

Francois Guillemot

Full details

Generation of an iPSC line (CRICKi001-A) from an individual with a germline SMARCA4 missense mutation and autism spectrum disorder

Authors (5)

Stem Cell Research

Published 1 May 2021

Crick labs/ facilities

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Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

Authors (10)

Cell Stem Cell

Published 6 May 2021

Crick labs/ facilities

Full details

Familial Alzheimer's disease mutations in PSEN1 lead to premature human stem cell neurogenesis

Authors (15)

Charles Arber
Christopher Lovejoy
Lachlan Harris
Nanet Willumsen
Argyro Alatza
Jackie M Casey
[...]
John Hardy
Natalie S Ryan
Nick C Fox
Tammaryn Lashley
Selina Wray

Cell Reports

Published 12 January 2021

Crick labs

Francois Guillemot

Full details

Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging

Authors (13)

Sara Bottes
Baptiste N Jaeger
Gregor-Alexander Pilz
David J Jörg
John Darby Cole
Merit Kruse
[...]
Izaskun Mallona
Fritjof Helmchen
Francois Guillemot
Benjamin D Simons
Sebastian Jessberger

Nature Neuroscience

Published 1 February 2021

Crick labs

Francois Guillemot

Full details

De novo SMARCA2 variants clustered outside the helicase domain cause a new recognizable syndrome with intellectual disability and blepharophimosis distinct from Nicolaides-Baraitser syndrome

Authors (48)

Gerarda Cappuccio
Camille Sayou
Pauline Le Tanno
Emilie Tisserant
Ange-Line Bruel
Sara El Kennani
[...]
Bekim Sadikovic
Julien Thevenon
Jérôme Govin
Antonio Vitobello
Nicola Brunetti-Pierri

Genetics in Medicine

Published 1 November 2020

Crick labs

Francois Guillemot

Full details

Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development

Authors (15)

Dong Liu
Anastasia I Kousa
Kathy E O'Neill
Paul Rouse
Martyna Popis
Alison M Farley
[...]
Mette C Jørgensen
Palle Serup
Ute Koch
Freddy Radtke
C Clare Blackburn

Development

Published 22 June 2020

Crick labs

Francois Guillemot

Full details

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Bumetanide induces post-traumatic microglia-interneuron contact to promote neurogenesis and recovery

Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation

A mouse model with a frameshift mutation in the nuclear factor I/X (NFIX) gene has phenotypic features of Marshall‐Smith syndrome

Fluorescence-activated nuclei negative sorting of neurons combined with single nuclei RNA sequencing to study the hippocampal neurogenic niche

Editorial: Transcription and chromatin regulators in neurodevelopmental disorders

DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential

The relationship between epigenetic age and the hallmarks of ageing in human cells

Understanding astrocyte differentiation: Clinical relevance, technical challenges, and new opportunities in the omics era

The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis

Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation

Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior

Identifying cellular signalling molecules in developmental disorders of the brain: Evidence from focal cortical dysplasia and tuberous sclerosis

Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice

Generation of an iPSC line (CRICKi001-A) from an individual with a germline SMARCA4 missense mutation and autism spectrum disorder

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

Familial Alzheimer's disease mutations in PSEN1 lead to premature human stem cell neurogenesis

Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging

De novo SMARCA2 variants clustered outside the helicase domain cause a new recognizable syndrome with intellectual disability and blepharophimosis distinct from Nicolaides-Baraitser syndrome

Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development

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