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Breadcrumb Frank Uhlmann Uhlmann lab Chromosome Segregation Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Chromosomes (pink) in the fission yeast S. pombe, one of the model organisms used in our research. Toggle to view hero caption PublicationsYear published2022 (2)2021 (4)2020 (4)2019 (2)2018 (2)2017 (3) Facet Year publishedResearch topicsBiochemistry & Proteomics (17)Cell Cycle & Chromosomes (17)Computational & Systems Biology (17)Genetics & Genomics (17)Model Organisms (17)Genome Integrity & Repair (11)Tumour Biology (9)Structural Biology & Biophysics (7)Imaging (3)Infectious Disease (1) (-)Chemical Biology & High Throughput (17) Facet Research topicsPublication typeJournal article (17)Primary research (16)Method (1) Facet Publication typeJournalMolecular Cell (4)Cell Reports (2)Nature Communications (2)EMBO Journal (1)Genome Biology (1)Life Science Alliance (1)Nature Structural & Molecular Biology (1)Nucleic Acids Research (1)PLOS ONE (1)Science advances (1)Scientific Reports (1)STAR Protocols (1) Facet Journal Publications Displaying 1 - 17 of 17Last updated : 18 April 2024 03:36 Functional crosstalk between the cohesin loader and chromatin remodelers Authors (6)Sofia Munoz-FelixAndrew JonesCeline Bouchoux Tegan Gilmore Harshil PatelFrank Uhlmann Nature Communications Published 13 December 2022 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyHigh Throughput ScreeningFermentationFull details Chromosome arm length, and a species-specific determinant, define chromosome arm width Authors (7)Yasutaka Kakui Christopher Barrington Yoshiharu Kusano Rahul ThadaniTodd Fallesen Toru HirotaFrank Uhlmann Cell Reports Published 6 December 2022 Crick labs/ facilitiesFrank UhlmannLight MicroscopyBioinformatics and BiostatisticsFull details Budding yeast relies on G1 cyclin specificity to couple cell cycle progression with morphogenetic development Authors (6)Deniz Pirincci Ercan Florine Chrétien Probir Chakravarty Helen R FlynnBram SnijdersFrank Uhlmann Science advances Published 4 June 2021 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyFull details A role for condensin in mediating transcriptional adaptation to environmental stimuli Authors (4)Lucy Lancaster Harshil PatelGavin KellyFrank Uhlmann Life Science Alliance Published 1 July 2021 Crick labs/ facilitiesFrank UhlmannBioinformatics and BiostatisticsAdvanced SequencingFull details Structural characterisation of the Chaetomium thermophilum Chl1 helicase Authors (8)Zuzana HodakovaAndrea NansSimone KunzelmannShahid MehmoodIan TaylorFrank UhlmannPeter Cherepanov Martin R Singleton PLOS ONE Published 10 May 2021 Crick labs/ facilitiesFrank UhlmannIan TaylorMartin SingletonPeter Cherepanov Structural BiologyProteomicsFull details Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast Authors (7)Tereza ClarenceXiao FuYasutaka Kakui Bhavin S Khatri Christopher BarringtonPaul BatesFrank Uhlmann Nucleic Acids Research Published 22 February 2021 Crick labs/ facilitiesFrank UhlmannPaul BatesBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage Authors (8)Yasutaka Kakui Christopher BarringtonDavid BarryTereza ClarenceXiao FuPaul Bates Bhavin S KhatriFrank Uhlmann Genome Biology Published 5 November 2020 Crick labs/ facilitiesFrank UhlmannPaul BatesLight MicroscopyBioinformatics and BiostatisticsAdvanced SequencingFull details A structure-based mechanism for DNA entry into the cohesin ring Authors (14)Torahiko HigashiCarl Eickhoff Joana S SousaJulia LockeAndrea Nans Helen R Flynn[...] Zhuo A Chen Francis J O’Reilly Juri RappsilberAlessandro CostaFrank Uhlmann Molecular Cell Published 17 September 2020 Crick labs/ facilitiesFrank UhlmannAlessandro CostaStructural BiologyProteomicsFermentationFull details Assessing budding yeast phosphoproteome dynamics in a time-resolved manner using TMT10plex mass tag labeling Authors (5)Andrew Jones Helen R FlynnFrank UhlmannBram SnijdersSandra Touati STAR Protocols Published 19 June 2020 Crick labs/ facilitiesFrank UhlmannProteomicsFull details Division of labor between PCNA loaders in DNA replication and sister chromatid cohesion establishment Authors (6)Hon-Wing LiuCeline Bouchoux Mélanie PanarottoYasutaka Kakui Harshil PatelFrank Uhlmann Molecular Cell Published 21 May 2020 Crick labs/ facilitiesFrank UhlmannBioinformatics and BiostatisticsAdvanced SequencingFull details Cdc14 and PP2A phosphatases cooperate to shape phosphoproteome dynamics during mitotic exit Authors (6)Sandra TouatiLorena HofbauerAndrew JonesBram SnijdersGavin KellyFrank Uhlmann Cell Reports Published 12 November 2019 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsFull details A role for chromatin remodeling in cohesin loading onto chromosomes Authors (5)Sofia Munoz-FelixMasashi Minamino Corella S Casas-Delucchi Harshil PatelFrank Uhlmann Molecular Cell Published 16 May 2019 Crick labs/ facilitiesFrank UhlmannJohn DiffleyBioinformatics and BiostatisticsHigh Throughput ScreeningFermentationFull details A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase Authors (6) Meghna KatariaStephane Mouilleron Moon-Hyeong Seo Carles Corbi-Verge Philip M KimFrank Uhlmann Nature Structural & Molecular Biology Published 19 November 2018 Crick labs/ facilitiesFrank UhlmannStructural BiologyFull details Phosphoproteome dynamics during mitotic exit in budding yeast Authors (5)Sandra Touati Meghna KatariaAndrew JonesBram SnijdersFrank Uhlmann EMBO Journal Published 15 May 2018 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsFull details Structural basis of Eco1-mediated cohesin acetylation Authors (10) William CH Chao Benjamin O WadeCeline BouchouxAndrew Jones Andrew G PurkissStefania FedericoNicola O'ReillyBram SnijdersFrank Uhlmann Martin R Singleton Scientific Reports Published 14 March 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonStructural BiologyProteomicsFull details PP2ACdc55 phosphatase imposes ordered cell-cycle phosphorylation by opposing threonine phosphorylation Authors (6) Molly GodfreySandra Touati Meghna KatariaAndrew JonesBram SnijdersFrank Uhlmann Molecular Cell Published 2 February 2017 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsFull details Structure of the cohesin loader Scc2 Authors (11) William CH Chao Yasuto MurayamaSofia Munoz-FelixAndrew Jones Benjamin O Wade Andrew G Purkiss Xiao-Wen Hu Aaron BorgBram SnijdersFrank Uhlmann Martin R Singleton Nature Communications Published 6 January 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonProteomicsElectron MicroscopyFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Functional crosstalk between the cohesin loader and chromatin remodelers Authors (6)Sofia Munoz-FelixAndrew JonesCeline Bouchoux Tegan Gilmore Harshil PatelFrank Uhlmann Nature Communications Published 13 December 2022 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyHigh Throughput ScreeningFermentationFull details
Chromosome arm length, and a species-specific determinant, define chromosome arm width Authors (7)Yasutaka Kakui Christopher Barrington Yoshiharu Kusano Rahul ThadaniTodd Fallesen Toru HirotaFrank Uhlmann Cell Reports Published 6 December 2022 Crick labs/ facilitiesFrank UhlmannLight MicroscopyBioinformatics and BiostatisticsFull details
Budding yeast relies on G1 cyclin specificity to couple cell cycle progression with morphogenetic development Authors (6)Deniz Pirincci Ercan Florine Chrétien Probir Chakravarty Helen R FlynnBram SnijdersFrank Uhlmann Science advances Published 4 June 2021 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyFull details
A role for condensin in mediating transcriptional adaptation to environmental stimuli Authors (4)Lucy Lancaster Harshil PatelGavin KellyFrank Uhlmann Life Science Alliance Published 1 July 2021 Crick labs/ facilitiesFrank UhlmannBioinformatics and BiostatisticsAdvanced SequencingFull details
Structural characterisation of the Chaetomium thermophilum Chl1 helicase Authors (8)Zuzana HodakovaAndrea NansSimone KunzelmannShahid MehmoodIan TaylorFrank UhlmannPeter Cherepanov Martin R Singleton PLOS ONE Published 10 May 2021 Crick labs/ facilitiesFrank UhlmannIan TaylorMartin SingletonPeter Cherepanov Structural BiologyProteomicsFull details
Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast Authors (7)Tereza ClarenceXiao FuYasutaka Kakui Bhavin S Khatri Christopher BarringtonPaul BatesFrank Uhlmann Nucleic Acids Research Published 22 February 2021 Crick labs/ facilitiesFrank UhlmannPaul BatesBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage Authors (8)Yasutaka Kakui Christopher BarringtonDavid BarryTereza ClarenceXiao FuPaul Bates Bhavin S KhatriFrank Uhlmann Genome Biology Published 5 November 2020 Crick labs/ facilitiesFrank UhlmannPaul BatesLight MicroscopyBioinformatics and BiostatisticsAdvanced SequencingFull details
A structure-based mechanism for DNA entry into the cohesin ring Authors (14)Torahiko HigashiCarl Eickhoff Joana S SousaJulia LockeAndrea Nans Helen R Flynn[...] Zhuo A Chen Francis J O’Reilly Juri RappsilberAlessandro CostaFrank Uhlmann Molecular Cell Published 17 September 2020 Crick labs/ facilitiesFrank UhlmannAlessandro CostaStructural BiologyProteomicsFermentationFull details
Assessing budding yeast phosphoproteome dynamics in a time-resolved manner using TMT10plex mass tag labeling Authors (5)Andrew Jones Helen R FlynnFrank UhlmannBram SnijdersSandra Touati STAR Protocols Published 19 June 2020 Crick labs/ facilitiesFrank UhlmannProteomicsFull details
Division of labor between PCNA loaders in DNA replication and sister chromatid cohesion establishment Authors (6)Hon-Wing LiuCeline Bouchoux Mélanie PanarottoYasutaka Kakui Harshil PatelFrank Uhlmann Molecular Cell Published 21 May 2020 Crick labs/ facilitiesFrank UhlmannBioinformatics and BiostatisticsAdvanced SequencingFull details
Cdc14 and PP2A phosphatases cooperate to shape phosphoproteome dynamics during mitotic exit Authors (6)Sandra TouatiLorena HofbauerAndrew JonesBram SnijdersGavin KellyFrank Uhlmann Cell Reports Published 12 November 2019 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsFull details
A role for chromatin remodeling in cohesin loading onto chromosomes Authors (5)Sofia Munoz-FelixMasashi Minamino Corella S Casas-Delucchi Harshil PatelFrank Uhlmann Molecular Cell Published 16 May 2019 Crick labs/ facilitiesFrank UhlmannJohn DiffleyBioinformatics and BiostatisticsHigh Throughput ScreeningFermentationFull details
A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase Authors (6) Meghna KatariaStephane Mouilleron Moon-Hyeong Seo Carles Corbi-Verge Philip M KimFrank Uhlmann Nature Structural & Molecular Biology Published 19 November 2018 Crick labs/ facilitiesFrank UhlmannStructural BiologyFull details
Phosphoproteome dynamics during mitotic exit in budding yeast Authors (5)Sandra Touati Meghna KatariaAndrew JonesBram SnijdersFrank Uhlmann EMBO Journal Published 15 May 2018 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsFull details
Structural basis of Eco1-mediated cohesin acetylation Authors (10) William CH Chao Benjamin O WadeCeline BouchouxAndrew Jones Andrew G PurkissStefania FedericoNicola O'ReillyBram SnijdersFrank Uhlmann Martin R Singleton Scientific Reports Published 14 March 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonStructural BiologyProteomicsFull details
PP2ACdc55 phosphatase imposes ordered cell-cycle phosphorylation by opposing threonine phosphorylation Authors (6) Molly GodfreySandra Touati Meghna KatariaAndrew JonesBram SnijdersFrank Uhlmann Molecular Cell Published 2 February 2017 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsFull details
Structure of the cohesin loader Scc2 Authors (11) William CH Chao Yasuto MurayamaSofia Munoz-FelixAndrew Jones Benjamin O Wade Andrew G Purkiss Xiao-Wen Hu Aaron BorgBram SnijdersFrank Uhlmann Martin R Singleton Nature Communications Published 6 January 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonProteomicsElectron MicroscopyFull details