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Breadcrumb Frank Uhlmann Uhlmann lab Chromosome Segregation Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Chromosomes (pink) in the fission yeast S. pombe, one of the model organisms used in our research. Toggle to view hero caption PublicationsYear published2023 (3)2021 (3)2020 (2)2018 (1)2017 (4)2016 (2)2015 (2) Facet Year publishedResearch topicsBiochemistry & Proteomics (17)Cell Cycle & Chromosomes (17)Computational & Systems Biology (17)Genetics & Genomics (17)Model Organisms (17)Imaging (8)Chemical Biology & High Throughput (7)Genome Integrity & Repair (7)Cell Biology (5)Microfabrication & Bioengineering (4)Tumour Biology (2)Infectious Disease (1) (-)Structural Biology & Biophysics (17) Facet Research topicsPublication typeJournal article (17)Primary research (16)Commentary (1) Facet Publication typeJournalMolecular Cell (3)eLife (2)Nature Structural & Molecular Biology (2)Cell (1)Cell Reports (1)EMBO Journal (1)EMBO Reports (1)Genome Biology (1)Nature Communications (1)Nature Structural and Molecular Biology (1)Nucleic Acids Research (1)PLOS ONE (1)Scientific Reports (1) Facet Journal Publications Displaying 1 - 17 of 17Last updated : 29 March 2024 03:54 Mechanical disengagement of the cohesin ring Authors (6)Martina RicheldiGeorge PobegalovTorahiko HigashiKarolina GmurczykFrank UhlmannMaxim Molodtsov Nature Structural and Molecular Biology Published 1 January 2024 Crick labsFrank UhlmannMaxim MolodtsovFull details Establishment of dsDNA-dsDNA interactions by the condensin complex Authors (8)Tony TangGeorge Pobegalov Hideki Tanizawa Zhuo A Chen Juri RappsilberMaxim Molodtsov Ken-ichi NomaFrank Uhlmann Molecular Cell Published 1 November 2023 Crick labs/ facilitiesFrank UhlmannMaxim MolodtsovFermentationBioinformatics and BiostatisticsFull details A replication fork determinant for the establishment of sister chromatid cohesion Authors (5)Masashi MinaminoCeline BouchouxBerta CanalJohn DiffleyFrank Uhlmann Cell Published 16 February 2023 Crick labs/ facilitiesFrank UhlmannJohn DiffleyStructural BiologyFermentationFull details A Brownian ratchet model for DNA loop extrusion by the cohesin complex Authors (5)Torahiko HigashiGeorge PobegalovTony TangMaxim MolodtsovFrank Uhlmann eLife Published 26 July 2021 Crick labs/ facilitiesFrank UhlmannMaxim MolodtsovStructural BiologyFull details Structural characterisation of the Chaetomium thermophilum Chl1 helicase Authors (8)Zuzana HodakovaAndrea NansSimone KunzelmannShahid MehmoodIan TaylorFrank UhlmannPeter Cherepanov Martin R Singleton PLOS ONE Published 10 May 2021 Crick labs/ facilitiesFrank UhlmannIan TaylorMartin SingletonPeter Cherepanov Structural BiologyProteomicsFull details Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast Authors (7)Tereza ClarenceXiao FuYasutaka Kakui Bhavin S Khatri Christopher BarringtonPaul BatesFrank Uhlmann Nucleic Acids Research Published 22 February 2021 Crick labs/ facilitiesFrank UhlmannPaul BatesBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage Authors (8)Yasutaka Kakui Christopher BarringtonDavid BarryTereza ClarenceXiao FuPaul Bates Bhavin S KhatriFrank Uhlmann Genome Biology Published 5 November 2020 Crick labs/ facilitiesFrank UhlmannPaul BatesLight MicroscopyBioinformatics and BiostatisticsAdvanced SequencingFull details A structure-based mechanism for DNA entry into the cohesin ring Authors (14)Torahiko HigashiCarl Eickhoff Joana S SousaJulia LockeAndrea Nans Helen R Flynn[...] Zhuo A Chen Francis J O’Reilly Juri RappsilberAlessandro CostaFrank Uhlmann Molecular Cell Published 17 September 2020 Crick labs/ facilitiesFrank UhlmannAlessandro CostaStructural BiologyProteomicsFermentationFull details A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase Authors (6) Meghna KatariaStephane Mouilleron Moon-Hyeong Seo Carles Corbi-Verge Philip M KimFrank Uhlmann Nature Structural & Molecular Biology Published 19 November 2018 Crick labs/ facilitiesFrank UhlmannStructural BiologyFull details Separase-securin complex: a cunning way to control chromosome segregation Authors (2) Martin R SingletonFrank Uhlmann Nature Structural & Molecular Biology Published 6 April 2017 Crick labsFrank UhlmannMartin SingletonFull details Structural basis of Eco1-mediated cohesin acetylation Authors (10) William CH Chao Benjamin O WadeCeline BouchouxAndrew Jones Andrew G PurkissStefania FedericoNicola O'ReillyBram SnijdersFrank Uhlmann Martin R Singleton Scientific Reports Published 14 March 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonStructural BiologyProteomicsFull details Structural studies of RFCCtf18 reveal a novel chromatin recruitment role for Dcc1 Authors (5) Benjamin O WadeHon-Wing Liu Catarina P SamoraFrank Uhlmann Martin R Singleton EMBO Reports Published 1 April 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonStructural BiologyProteomicsBioinformatics and BiostatisticsFull details Structure of the cohesin loader Scc2 Authors (11) William CH Chao Yasuto MurayamaSofia Munoz-FelixAndrew Jones Benjamin O Wade Andrew G Purkiss Xiao-Wen Hu Aaron BorgBram SnijdersFrank Uhlmann Martin R Singleton Nature Communications Published 6 January 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonProteomicsElectron MicroscopyFull details Rapid movement and transcriptional re-localization of human cohesin on DNA Authors (13) Iain F Davidson Daniela Goetz Maciej P ZaczekMaxim Molodtsov Pim J Huis in 't VeldFlorian Weissmann[...] Maria Ocampo-Hafalla Rene LadurnerFrank Uhlmann Alipasha Vaziri Jan-Michael Peters EMBO Journal Published 15 December 2016 Crick labsFrank UhlmannMaxim MolodtsovFull details Ctf4 links DNA replication with sister chromatid cohesion establishment by recruiting the Chl1 helicase to the replisome Authors (9) Catarina P Samora Julie Saksouk Panchali Goswami Ben O Wade Martin R SingletonPaul Bates Armelle LengronneAlessandro CostaFrank Uhlmann Molecular Cell Published 4 August 2016 Crick labsFrank UhlmannMartin SingletonAlessandro CostaPaul BatesFull details Structural studies reveal the functional modularity of the Scc2-Scc4 cohesin loader Authors (6) William CH Chao Yasuto MurayamaSofia Munoz-FelixAlessandro CostaFrank Uhlmann Martin R Singleton Cell Reports Published 4 August 2015 Crick labs/ facilitiesFrank UhlmannMartin SingletonAlessandro CostaStructural BiologyProteomicsElectron MicroscopyFull details A simple biophysical model emulates budding yeast chromosome condensation Authors (9) Tammy MK Cheng Sebastian HeegerRaphael Chaleil Nik MatthewsAengus Stewart Jon Wright Carmay LimPaul BatesFrank Uhlmann eLife Published 29 April 2015 Crick labs/ facilitiesFrank UhlmannPaul BatesBioinformatics and BiostatisticsAdvanced SequencingFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Mechanical disengagement of the cohesin ring Authors (6)Martina RicheldiGeorge PobegalovTorahiko HigashiKarolina GmurczykFrank UhlmannMaxim Molodtsov Nature Structural and Molecular Biology Published 1 January 2024 Crick labsFrank UhlmannMaxim MolodtsovFull details
Establishment of dsDNA-dsDNA interactions by the condensin complex Authors (8)Tony TangGeorge Pobegalov Hideki Tanizawa Zhuo A Chen Juri RappsilberMaxim Molodtsov Ken-ichi NomaFrank Uhlmann Molecular Cell Published 1 November 2023 Crick labs/ facilitiesFrank UhlmannMaxim MolodtsovFermentationBioinformatics and BiostatisticsFull details
A replication fork determinant for the establishment of sister chromatid cohesion Authors (5)Masashi MinaminoCeline BouchouxBerta CanalJohn DiffleyFrank Uhlmann Cell Published 16 February 2023 Crick labs/ facilitiesFrank UhlmannJohn DiffleyStructural BiologyFermentationFull details
A Brownian ratchet model for DNA loop extrusion by the cohesin complex Authors (5)Torahiko HigashiGeorge PobegalovTony TangMaxim MolodtsovFrank Uhlmann eLife Published 26 July 2021 Crick labs/ facilitiesFrank UhlmannMaxim MolodtsovStructural BiologyFull details
Structural characterisation of the Chaetomium thermophilum Chl1 helicase Authors (8)Zuzana HodakovaAndrea NansSimone KunzelmannShahid MehmoodIan TaylorFrank UhlmannPeter Cherepanov Martin R Singleton PLOS ONE Published 10 May 2021 Crick labs/ facilitiesFrank UhlmannIan TaylorMartin SingletonPeter Cherepanov Structural BiologyProteomicsFull details
Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast Authors (7)Tereza ClarenceXiao FuYasutaka Kakui Bhavin S Khatri Christopher BarringtonPaul BatesFrank Uhlmann Nucleic Acids Research Published 22 February 2021 Crick labs/ facilitiesFrank UhlmannPaul BatesBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage Authors (8)Yasutaka Kakui Christopher BarringtonDavid BarryTereza ClarenceXiao FuPaul Bates Bhavin S KhatriFrank Uhlmann Genome Biology Published 5 November 2020 Crick labs/ facilitiesFrank UhlmannPaul BatesLight MicroscopyBioinformatics and BiostatisticsAdvanced SequencingFull details
A structure-based mechanism for DNA entry into the cohesin ring Authors (14)Torahiko HigashiCarl Eickhoff Joana S SousaJulia LockeAndrea Nans Helen R Flynn[...] Zhuo A Chen Francis J O’Reilly Juri RappsilberAlessandro CostaFrank Uhlmann Molecular Cell Published 17 September 2020 Crick labs/ facilitiesFrank UhlmannAlessandro CostaStructural BiologyProteomicsFermentationFull details
A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase Authors (6) Meghna KatariaStephane Mouilleron Moon-Hyeong Seo Carles Corbi-Verge Philip M KimFrank Uhlmann Nature Structural & Molecular Biology Published 19 November 2018 Crick labs/ facilitiesFrank UhlmannStructural BiologyFull details
Separase-securin complex: a cunning way to control chromosome segregation Authors (2) Martin R SingletonFrank Uhlmann Nature Structural & Molecular Biology Published 6 April 2017 Crick labsFrank UhlmannMartin SingletonFull details
Structural basis of Eco1-mediated cohesin acetylation Authors (10) William CH Chao Benjamin O WadeCeline BouchouxAndrew Jones Andrew G PurkissStefania FedericoNicola O'ReillyBram SnijdersFrank Uhlmann Martin R Singleton Scientific Reports Published 14 March 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonStructural BiologyProteomicsFull details
Structural studies of RFCCtf18 reveal a novel chromatin recruitment role for Dcc1 Authors (5) Benjamin O WadeHon-Wing Liu Catarina P SamoraFrank Uhlmann Martin R Singleton EMBO Reports Published 1 April 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonStructural BiologyProteomicsBioinformatics and BiostatisticsFull details
Structure of the cohesin loader Scc2 Authors (11) William CH Chao Yasuto MurayamaSofia Munoz-FelixAndrew Jones Benjamin O Wade Andrew G Purkiss Xiao-Wen Hu Aaron BorgBram SnijdersFrank Uhlmann Martin R Singleton Nature Communications Published 6 January 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonProteomicsElectron MicroscopyFull details
Rapid movement and transcriptional re-localization of human cohesin on DNA Authors (13) Iain F Davidson Daniela Goetz Maciej P ZaczekMaxim Molodtsov Pim J Huis in 't VeldFlorian Weissmann[...] Maria Ocampo-Hafalla Rene LadurnerFrank Uhlmann Alipasha Vaziri Jan-Michael Peters EMBO Journal Published 15 December 2016 Crick labsFrank UhlmannMaxim MolodtsovFull details
Ctf4 links DNA replication with sister chromatid cohesion establishment by recruiting the Chl1 helicase to the replisome Authors (9) Catarina P Samora Julie Saksouk Panchali Goswami Ben O Wade Martin R SingletonPaul Bates Armelle LengronneAlessandro CostaFrank Uhlmann Molecular Cell Published 4 August 2016 Crick labsFrank UhlmannMartin SingletonAlessandro CostaPaul BatesFull details
Structural studies reveal the functional modularity of the Scc2-Scc4 cohesin loader Authors (6) William CH Chao Yasuto MurayamaSofia Munoz-FelixAlessandro CostaFrank Uhlmann Martin R Singleton Cell Reports Published 4 August 2015 Crick labs/ facilitiesFrank UhlmannMartin SingletonAlessandro CostaStructural BiologyProteomicsElectron MicroscopyFull details
A simple biophysical model emulates budding yeast chromosome condensation Authors (9) Tammy MK Cheng Sebastian HeegerRaphael Chaleil Nik MatthewsAengus Stewart Jon Wright Carmay LimPaul BatesFrank Uhlmann eLife Published 29 April 2015 Crick labs/ facilitiesFrank UhlmannPaul BatesBioinformatics and BiostatisticsAdvanced SequencingFull details