Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Frank Uhlmann Uhlmann lab Chromosome Segregation Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Chromosomes (pink) in the fission yeast S. pombe, one of the model organisms used in our research. Toggle to view hero caption PublicationsYear published2024 (1)2023 (5)2022 (4)2021 (7)2020 (6)2019 (3)2018 (7)2017 (9)2016 (6)2015 (6)2014 (5)2013 (4)2012 (3)2011 (6)2010 (5) Facet Year publishedResearch topicsCell Cycle & Chromosomes (53)Computational & Systems Biology (53)Genetics & Genomics (53)Model Organisms (53)Biochemistry & Proteomics (52)Chemical Biology & High Throughput (17)Structural Biology & Biophysics (17)Genome Integrity & Repair (14)Imaging (9)Tumour Biology (9)Cell Biology (6)Microfabrication & Bioengineering (4)Infectious Disease (1) Facet Research topicsPublication typeJournal article (77)Primary research (54)Commentary (11)Review (7)Method (4)Editorial (1) Facet Publication typeJournalMolecular Cell (7)Current Biology (6)Cell (4)Cell Reports (4)EMBO Journal (4)Chromosoma (3)Methods in Molecular Biology (3)Current Genetics (2)Current Opinion in Cell Biology (2)eLife (2)EMBO Reports (2)Life Science Alliance (2)Nature Communications (2)Nature Genetics (2)Nature Reviews Molecular Cell Biology (2)Nature Structural & Molecular Biology (2)Nucleic Acids Research (2)Open Biology (2)Science (2)Science advances (2)Yeast (2)Biochemical Society Transactions (1)Biochimica et Biophysica Acta (1)Bioinformatics (1)BMC Biology (1)Genes & Development (1)Genome Biology (1)Journal of Cell Science (1)Journal of the Royal Society, Interface / the Royal Society (1)Microbial Cell (1)Nature (1)Nature Structural and Molecular Biology (1)Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1)PLOS Genetics (1)PLOS ONE (1)Proceedings of the National Academy of Sciences of the United States of America (1)Scientific Reports (1)STAR Protocols (1)The EMBO Journal (1) Facet Journal Publications Displaying 21 - 40 of 77Last updated : 29 March 2024 03:34 Assessing budding yeast phosphoproteome dynamics in a time-resolved manner using TMT10plex mass tag labeling Authors (5)Andrew Jones Helen R FlynnFrank UhlmannBram SnijdersSandra Touati STAR Protocols Published 19 June 2020 Crick labs/ facilitiesFrank UhlmannProteomicsFull details Conserved roles of chromatin remodellers in cohesin loading onto chromatin Authors (3)Sofia Munoz-FelixFrancesca PassarelliFrank Uhlmann Current Genetics Published 1 October 2020 Crick labsFrank UhlmannFull details Division of labor between PCNA loaders in DNA replication and sister chromatid cohesion establishment Authors (6)Hon-Wing LiuCeline Bouchoux Mélanie PanarottoYasutaka Kakui Harshil PatelFrank Uhlmann Molecular Cell Published 21 May 2020 Crick labs/ facilitiesFrank UhlmannBioinformatics and BiostatisticsAdvanced SequencingFull details Cdc14 and PP2A phosphatases cooperate to shape phosphoproteome dynamics during mitotic exit Authors (6)Sandra TouatiLorena HofbauerAndrew JonesBram SnijdersGavin KellyFrank Uhlmann Cell Reports Published 12 November 2019 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsFull details Efficient depletion of fission yeast condensin by combined transcriptional repression and auxin-induced degradation Authors (2)Yasutaka KakuiFrank Uhlmann Methods in Molecular Biology Published 31 May 2019 Crick labsFrank UhlmannFull details A role for chromatin remodeling in cohesin loading onto chromosomes Authors (5)Sofia Munoz-FelixMasashi Minamino Corella S Casas-Delucchi Harshil PatelFrank Uhlmann Molecular Cell Published 16 May 2019 Crick labs/ facilitiesFrank UhlmannJohn DiffleyBioinformatics and BiostatisticsHigh Throughput ScreeningFermentationFull details A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase Authors (6) Meghna KatariaStephane Mouilleron Moon-Hyeong Seo Carles Corbi-Verge Philip M KimFrank Uhlmann Nature Structural & Molecular Biology Published 19 November 2018 Crick labs/ facilitiesFrank UhlmannStructural BiologyFull details Topological in vitro loading of the budding yeast cohesin ring onto DNA Authors (4)Masashi MinaminoTorahiko HigashiCeline BouchouxFrank Uhlmann Life Science Alliance Published 26 October 2018 Crick labs/ facilitiesFrank UhlmannFermentationFull details A global view of substrate phosphorylation and dephosphorylation during budding yeast mitotic exit Authors (2)Sandra TouatiFrank Uhlmann Microbial Cell Published 1 August 2018 Crick labsFrank UhlmannFull details Cell-cycle regulation of dynamic chromosome association of the condensin complex Authors (5) Rahul Thadani Julia Kamenz Sebastian HeegerSofia Munoz-FelixFrank Uhlmann Cell Reports Published 22 May 2018 Crick labs/ facilitiesFrank UhlmannProteomicsLight MicroscopyFull details Phosphoproteome dynamics during mitotic exit in budding yeast Authors (5)Sandra Touati Meghna KatariaAndrew JonesBram SnijdersFrank Uhlmann EMBO Journal Published 15 May 2018 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsFull details SMC complexes orchestrate the mitotic chromatin interaction landscape Authors (2)Yasutaka KakuiFrank Uhlmann Current Genetics Published 1 April 2018 Crick labsFrank UhlmannFull details Establishment of DNA-DNA interactions by the cohesin ring Authors (5) Yasuto Murayama Catarina P Samora Yumiko Kurokawa Hiroshi IwasakiFrank Uhlmann Cell Published 25 January 2018 Crick labsFrank UhlmannFull details Observation of DNA intertwining along authentic budding yeast chromosomes Authors (2) Ainhoa MariezcurrenaFrank Uhlmann Genes & Development Published 1 November 2017 Crick labsFrank UhlmannFull details The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukemia cell viability Authors (8)William Grey Adam Ivey Thomas A Milne Torsten Haferlach David GrimwadeFrank Uhlmann Edwige Voisset Veronica Yu Biochimica et Biophysica Acta Published 1 January 2018 Crick labsFrank UhlmannFull details Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast Authors (4)Yasutaka Kakui Adam RabinowitzDavid BarryFrank Uhlmann Nature Genetics Published 1 October 2017 Crick labs/ facilitiesFrank UhlmannLight MicroscopyBioinformatics and BiostatisticsFull details Building chromosomes without bricks Authors (2)Yasutaka KakuiFrank Uhlmann Science Published 23 June 2017 Crick labsFrank UhlmannFull details Separase-securin complex: a cunning way to control chromosome segregation Authors (2) Martin R SingletonFrank Uhlmann Nature Structural & Molecular Biology Published 6 April 2017 Crick labsFrank UhlmannMartin SingletonFull details Structural basis of Eco1-mediated cohesin acetylation Authors (10) William CH Chao Benjamin O WadeCeline BouchouxAndrew Jones Andrew G PurkissStefania FedericoNicola O'ReillyBram SnijdersFrank Uhlmann Martin R Singleton Scientific Reports Published 14 March 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonStructural BiologyProteomicsFull details Structural studies of RFCCtf18 reveal a novel chromatin recruitment role for Dcc1 Authors (5) Benjamin O WadeHon-Wing Liu Catarina P SamoraFrank Uhlmann Martin R Singleton EMBO Reports Published 1 April 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonStructural BiologyProteomicsBioinformatics and BiostatisticsFull details Pagination First page First Previous page Previous Page 1 Current page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Assessing budding yeast phosphoproteome dynamics in a time-resolved manner using TMT10plex mass tag labeling Authors (5)Andrew Jones Helen R FlynnFrank UhlmannBram SnijdersSandra Touati STAR Protocols Published 19 June 2020 Crick labs/ facilitiesFrank UhlmannProteomicsFull details
Conserved roles of chromatin remodellers in cohesin loading onto chromatin Authors (3)Sofia Munoz-FelixFrancesca PassarelliFrank Uhlmann Current Genetics Published 1 October 2020 Crick labsFrank UhlmannFull details
Division of labor between PCNA loaders in DNA replication and sister chromatid cohesion establishment Authors (6)Hon-Wing LiuCeline Bouchoux Mélanie PanarottoYasutaka Kakui Harshil PatelFrank Uhlmann Molecular Cell Published 21 May 2020 Crick labs/ facilitiesFrank UhlmannBioinformatics and BiostatisticsAdvanced SequencingFull details
Cdc14 and PP2A phosphatases cooperate to shape phosphoproteome dynamics during mitotic exit Authors (6)Sandra TouatiLorena HofbauerAndrew JonesBram SnijdersGavin KellyFrank Uhlmann Cell Reports Published 12 November 2019 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsFull details
Efficient depletion of fission yeast condensin by combined transcriptional repression and auxin-induced degradation Authors (2)Yasutaka KakuiFrank Uhlmann Methods in Molecular Biology Published 31 May 2019 Crick labsFrank UhlmannFull details
A role for chromatin remodeling in cohesin loading onto chromosomes Authors (5)Sofia Munoz-FelixMasashi Minamino Corella S Casas-Delucchi Harshil PatelFrank Uhlmann Molecular Cell Published 16 May 2019 Crick labs/ facilitiesFrank UhlmannJohn DiffleyBioinformatics and BiostatisticsHigh Throughput ScreeningFermentationFull details
A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase Authors (6) Meghna KatariaStephane Mouilleron Moon-Hyeong Seo Carles Corbi-Verge Philip M KimFrank Uhlmann Nature Structural & Molecular Biology Published 19 November 2018 Crick labs/ facilitiesFrank UhlmannStructural BiologyFull details
Topological in vitro loading of the budding yeast cohesin ring onto DNA Authors (4)Masashi MinaminoTorahiko HigashiCeline BouchouxFrank Uhlmann Life Science Alliance Published 26 October 2018 Crick labs/ facilitiesFrank UhlmannFermentationFull details
A global view of substrate phosphorylation and dephosphorylation during budding yeast mitotic exit Authors (2)Sandra TouatiFrank Uhlmann Microbial Cell Published 1 August 2018 Crick labsFrank UhlmannFull details
Cell-cycle regulation of dynamic chromosome association of the condensin complex Authors (5) Rahul Thadani Julia Kamenz Sebastian HeegerSofia Munoz-FelixFrank Uhlmann Cell Reports Published 22 May 2018 Crick labs/ facilitiesFrank UhlmannProteomicsLight MicroscopyFull details
Phosphoproteome dynamics during mitotic exit in budding yeast Authors (5)Sandra Touati Meghna KatariaAndrew JonesBram SnijdersFrank Uhlmann EMBO Journal Published 15 May 2018 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsFull details
SMC complexes orchestrate the mitotic chromatin interaction landscape Authors (2)Yasutaka KakuiFrank Uhlmann Current Genetics Published 1 April 2018 Crick labsFrank UhlmannFull details
Establishment of DNA-DNA interactions by the cohesin ring Authors (5) Yasuto Murayama Catarina P Samora Yumiko Kurokawa Hiroshi IwasakiFrank Uhlmann Cell Published 25 January 2018 Crick labsFrank UhlmannFull details
Observation of DNA intertwining along authentic budding yeast chromosomes Authors (2) Ainhoa MariezcurrenaFrank Uhlmann Genes & Development Published 1 November 2017 Crick labsFrank UhlmannFull details
The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukemia cell viability Authors (8)William Grey Adam Ivey Thomas A Milne Torsten Haferlach David GrimwadeFrank Uhlmann Edwige Voisset Veronica Yu Biochimica et Biophysica Acta Published 1 January 2018 Crick labsFrank UhlmannFull details
Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast Authors (4)Yasutaka Kakui Adam RabinowitzDavid BarryFrank Uhlmann Nature Genetics Published 1 October 2017 Crick labs/ facilitiesFrank UhlmannLight MicroscopyBioinformatics and BiostatisticsFull details
Building chromosomes without bricks Authors (2)Yasutaka KakuiFrank Uhlmann Science Published 23 June 2017 Crick labsFrank UhlmannFull details
Separase-securin complex: a cunning way to control chromosome segregation Authors (2) Martin R SingletonFrank Uhlmann Nature Structural & Molecular Biology Published 6 April 2017 Crick labsFrank UhlmannMartin SingletonFull details
Structural basis of Eco1-mediated cohesin acetylation Authors (10) William CH Chao Benjamin O WadeCeline BouchouxAndrew Jones Andrew G PurkissStefania FedericoNicola O'ReillyBram SnijdersFrank Uhlmann Martin R Singleton Scientific Reports Published 14 March 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonStructural BiologyProteomicsFull details
Structural studies of RFCCtf18 reveal a novel chromatin recruitment role for Dcc1 Authors (5) Benjamin O WadeHon-Wing Liu Catarina P SamoraFrank Uhlmann Martin R Singleton EMBO Reports Published 1 April 2017 Crick labs/ facilitiesFrank UhlmannMartin SingletonStructural BiologyProteomicsBioinformatics and BiostatisticsFull details