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Numerous retroviral particles (pseudocoloured) endogenously produced by lymphoma cells in an immune-deficient mouse. Toggle to view hero caption George Kassiotis : Publications Lab MenuLab Menu Overview Areas of interest Publications Members Vacancy Breadcrumb Home Research Labs George Kassiotis Publications PublicationsYear published2020 (8)2019 (6)2018 (2)2017 (4)2016 (6)2015 (1)2014 (6)2013 (3)2012 (4)2011 (2)2010 (2) Facet Year publishedResearch topicsComputational & Systems Biology (27)Genetics & Genomics (27)Model Organisms (26)Immunology (25)Infectious Disease (15)Structural Biology & Biophysics (15)Chemical Biology & High Throughput (5)Signalling & Oncogenes (4)Stem Cells (4)Tumour Biology (4)Cell Biology (3)Cell Cycle & Chromosomes (3)Developmental Biology (3)Genome Integrity & Repair (3)Human Biology & Physiology (3)Metabolism (3)Biochemistry & Proteomics (2)Imaging (2)Neurosciences (2)Gene Expression (1)Microfabrication & Bioengineering (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (44)Primary research (34)Review (8)Letter (1)Method (1) Facet Publication typeJournalJournal of Immunology (7)PLOS Pathogens (3)Retrovirology (3)Frontiers in Immunology (2)Journal of Virology (2)Nature (2)BioEssays (1)Blood (1)Cancer Immunology Research (1)Cell Host & Microbe (1)Cell Reports (1)Cellular and Molecular Immunology (1)Current Opinion in Immunology (1)eLife (1)EMBO Journal (1)FEMS Microbiology Reviews (1)Frontiers in Microbiology (1)Genome Medicine: medicine in the post-genomic era (1)Genome Research (1)Immunity (1)Journal of Experimental Medicine (1)Journal of General Virology (1)Journal of Leukocyte Biology (1)Nature Biotechnology (1)Nature Communications (1)Nature Genetics (1)Nature Reviews Immunology (1)Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1)Scientific Reports (1)The Lancet (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 20 of 44Last updated : 29 November 2020 03:26 Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option Authors (9)Kevin NgJan Attig William BollandGeorge YoungJack MajorAntoni WrobelSteve GamblinAndreas WackGeorge Kassiotis Nature Genetics Published 19 October 2020 Crick labs/ facilitiesSteve GamblinGeorge KassiotisJonathan StoyeAndreas WackAdvanced SequencingCell ServicesFlow CytometryScientific computingFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan Lewer Gavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesLuiz Pedro CarvalhoMike BlackmanDominique BonnetPeter Cherepanov Steve GamblinMaximiliano GutierrezGeorge KassiotisPaul NurseAnne O’GarraVenizelos PapayannopoulosLucia Prieto-GodinoPeter RatcliffeCaetano Reis e SousaErik SahaiCharles SwantonMoritz TreeckJames TurnerJernej UleKaren VousdenAndreas WackSonia GandhiRupert BealeAdam SaterialeAdvanced SequencingCell ServicesBioinformatics and BiostatisticsElectron MicroscopyExperimental HistopathologyFlow CytometryGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationWorldwide Influenza CentreHuman Embryonic Stem CellScientific computingFull details Restriction of memory B cell differentiation at the germinal center B cell positive selection stage Authors (13) Amparo Toboso-Navasa Arief Gunawan Giulia Morlino Rinako Nakagawa Andrea Taddei Djamil Damry[...] Martin JanzGeorge Kassiotis Robert Brink Martin EilersDinis Calado Journal of Experimental Medicine Published 6 July 2020 Crick labs/ facilitiesDinis CaladoGeorge KassiotisBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyExperimental HistopathologyFlow CytometryBiological Research FacilityFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen AmbroseSam BarrellRupert BealeGanka Bineva-ToddDhruva Biswas[...]Sophia Ward Wai Keong WongJoshua WrightMary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesPeter Cherepanov Steve GamblinGeorge KassiotisVenizelos PapayannopoulosPeter RatcliffeCaetano Reis e SousaCharles SwantonJames TurnerAndreas WackSonia GandhiRupert BealeAdvanced SequencingGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationScientific computingFull details Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event Authors (5)Veera PanovaJan AttigGeorge YoungJonathan StoyeGeorge Kassiotis PLOS Pathogens Published 26 May 2020 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeFlow CytometryBiological Research FacilityFull details Default polyfunctional T helper 1 response to ample signal 1 alone Authors (4)Luca Danelli Georgina Cornish Julia MerkenschlagerGeorge Kassiotis Cellular and Molecular Immunology Published 20 April 2020 Crick labs/ facilitiesGeorge KassiotisCell ServicesFlow CytometryBiological Research FacilityFull details Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation Authors (12) Huipeng Jiao Laurens Wachsmuth Snehlata Kumari Robin Schwarzer Juan Lin Remzi Onur Eren[...] Rebecca LaneGeorge YoungGeorge Kassiotis William J Kaiser Manolis Pasparakis Nature Published 25 March 2020 Crick labsGeorge KassiotisJonathan StoyeFull details Regulatory T cells restrain interleukin-2- and Blimp-1-dependent acquisition of cytotoxic function by CD4+ T cells Authors (22) Anna Śledzińska Maria Vila de Mucha Katharina Bergerhoff Alastair Hotblack Dafne Franz Demane Ehsan Ghorani[...] Graham M Lord Hans Stauss Richard G Jenner Karl S Peggs Sergio A Quezada Immunity Published 14 January 2020 Crick labsGeorge KassiotisFull details Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression Authors (12)Anastasiya KazachenkaGeorge YoungJan Attig Chrysoula Kordella Eleftheria Lamprianidou Emmanuela Zoulia[...] Menelaos Papoutselis Elsa Bernard Elli Papaemmanuil Ioannis KotsianidisGeorge Kassiotis Genome Medicine: medicine in the post-genomic era Published 23 December 2019 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeLight MicroscopyCell ServicesFlow CytometryScientific computingFull details Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist Authors (7)Kevin NgJan AttigGeorge YoungEleonora Ottina Spyros I Papamichos Ioannis KotsianidisGeorge Kassiotis eLife Published 15 November 2019 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeLight MicroscopyCell ServicesFlow CytometryHigh Throughput ScreeningScientific computingBiological Research FacilityFull details LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly Authors (9)Jan AttigGeorge YoungLou Hosie David Perkins Vesela Encheva-YokoyaJonathan StoyeBram Snijders Nicola TernetteGeorge Kassiotis Genome Research Published 1 October 2019 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeProteomicsPeptide ChemistryScientific computingFull details Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity Authors (8) Ulf Dittmer Kathrin SutterGeorge Kassiotis Gennadiy Zelinskyy Zoltán Bánki Heribert Stoiber Mario L Santiago Kim J Hasenkrug FEMS Microbiology Reviews Published 1 September 2019 Crick labsGeorge KassiotisFull details MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells Authors (8) Julia MerkenschlagerUrszula EksmondLuca DanelliJan AttigGeorge Young Carla NowosadPavel TolarGeorge Kassiotis Blood Published 30 January 2019 Crick labs/ facilitiesGeorge KassiotisJonathan StoyePavel TolarCell ServicesFlow CytometryHigh Throughput ScreeningBiological Research FacilityFull details A protective role for the lectin CD169/Siglec-1 against a pathogenic murine retrovirus Authors (11) Pradeep D Uchil Ruoxi Pi Kelsey A Haugh Mark S Ladinsky John D Ventura Brad S Barrett Mario L Santiago Pamela J BjorkmanGeorge Kassiotis Xaver Sewald Walther Mothes Cell Host & Microbe Published 1 January 2019 Crick labsGeorge KassiotisFull details Restoration of endogenous retrovirus infectivity impacts mouse cancer models Authors (10)Eleonora Ottina Prisca LevyUrszula Eksmond Julia MerkenschlagerGeorge Young Juliette RoelsJonathan Stoye Thomas TütingDinis CaladoGeorge Kassiotis Cancer Immunology Research Published 1 November 2018 Crick labs/ facilitiesDinis CaladoGeorge KassiotisJonathan StoyeFlow CytometryBiological Research FacilityFull details Correlates of follicular helper bias in the CD4 T cell response to a retroviral antigen Authors (3)Luca Danelli T DonnarummaGeorge Kassiotis Frontiers in Immunology Published 29 June 2018 Crick labs/ facilitiesGeorge KassiotisFlow CytometryBiological Research FacilityFull details Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells Authors (9) Martina Fontaine Isabel Vogel Yves-Rémi Van Eycke Adrien Galuppo Yousra Ajouaou Christine DecaesteckerGeorge Kassiotis Muriel Moser Oberdan Leo EMBO Journal Published 1 February 2018 Crick labsGeorge KassiotisFull details Physiological and pathological transcriptional activation of endogenous retroelements assessed by RNA-sequencing of B lymphocytes Authors (4)Jan AttigGeorge YoungJonathan StoyeGeorge Kassiotis Frontiers in Microbiology Published 12 December 2017 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeScientific computingFull details Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer Authors (2)George KassiotisJonathan Stoye Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Published 19 October 2017 Crick labsGeorge KassiotisJonathan StoyeFull details Mutation of the putative immunosuppressive domain of the retroviral envelope glycoprotein compromises infectivity Authors (6)Urszula Eksmond Bryony Jenkins Julia Merkenschlager Walther MothesJonathan StoyeGeorge Kassiotis Journal of Virology Published 1 November 2017 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeFlow CytometryBiological Research FacilityFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option Authors (9)Kevin NgJan Attig William BollandGeorge YoungJack MajorAntoni WrobelSteve GamblinAndreas WackGeorge Kassiotis Nature Genetics Published 19 October 2020 Crick labs/ facilitiesSteve GamblinGeorge KassiotisJonathan StoyeAndreas WackAdvanced SequencingCell ServicesFlow CytometryScientific computingFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan Lewer Gavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesLuiz Pedro CarvalhoMike BlackmanDominique BonnetPeter Cherepanov Steve GamblinMaximiliano GutierrezGeorge KassiotisPaul NurseAnne O’GarraVenizelos PapayannopoulosLucia Prieto-GodinoPeter RatcliffeCaetano Reis e SousaErik SahaiCharles SwantonMoritz TreeckJames TurnerJernej UleKaren VousdenAndreas WackSonia GandhiRupert BealeAdam SaterialeAdvanced SequencingCell ServicesBioinformatics and BiostatisticsElectron MicroscopyExperimental HistopathologyFlow CytometryGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationWorldwide Influenza CentreHuman Embryonic Stem CellScientific computingFull details
Restriction of memory B cell differentiation at the germinal center B cell positive selection stage Authors (13) Amparo Toboso-Navasa Arief Gunawan Giulia Morlino Rinako Nakagawa Andrea Taddei Djamil Damry[...] Martin JanzGeorge Kassiotis Robert Brink Martin EilersDinis Calado Journal of Experimental Medicine Published 6 July 2020 Crick labs/ facilitiesDinis CaladoGeorge KassiotisBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyExperimental HistopathologyFlow CytometryBiological Research FacilityFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen AmbroseSam BarrellRupert BealeGanka Bineva-ToddDhruva Biswas[...]Sophia Ward Wai Keong WongJoshua WrightMary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesPeter Cherepanov Steve GamblinGeorge KassiotisVenizelos PapayannopoulosPeter RatcliffeCaetano Reis e SousaCharles SwantonJames TurnerAndreas WackSonia GandhiRupert BealeAdvanced SequencingGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationScientific computingFull details
Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event Authors (5)Veera PanovaJan AttigGeorge YoungJonathan StoyeGeorge Kassiotis PLOS Pathogens Published 26 May 2020 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeFlow CytometryBiological Research FacilityFull details
Default polyfunctional T helper 1 response to ample signal 1 alone Authors (4)Luca Danelli Georgina Cornish Julia MerkenschlagerGeorge Kassiotis Cellular and Molecular Immunology Published 20 April 2020 Crick labs/ facilitiesGeorge KassiotisCell ServicesFlow CytometryBiological Research FacilityFull details
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation Authors (12) Huipeng Jiao Laurens Wachsmuth Snehlata Kumari Robin Schwarzer Juan Lin Remzi Onur Eren[...] Rebecca LaneGeorge YoungGeorge Kassiotis William J Kaiser Manolis Pasparakis Nature Published 25 March 2020 Crick labsGeorge KassiotisJonathan StoyeFull details
Regulatory T cells restrain interleukin-2- and Blimp-1-dependent acquisition of cytotoxic function by CD4+ T cells Authors (22) Anna Śledzińska Maria Vila de Mucha Katharina Bergerhoff Alastair Hotblack Dafne Franz Demane Ehsan Ghorani[...] Graham M Lord Hans Stauss Richard G Jenner Karl S Peggs Sergio A Quezada Immunity Published 14 January 2020 Crick labsGeorge KassiotisFull details
Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression Authors (12)Anastasiya KazachenkaGeorge YoungJan Attig Chrysoula Kordella Eleftheria Lamprianidou Emmanuela Zoulia[...] Menelaos Papoutselis Elsa Bernard Elli Papaemmanuil Ioannis KotsianidisGeorge Kassiotis Genome Medicine: medicine in the post-genomic era Published 23 December 2019 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeLight MicroscopyCell ServicesFlow CytometryScientific computingFull details
Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist Authors (7)Kevin NgJan AttigGeorge YoungEleonora Ottina Spyros I Papamichos Ioannis KotsianidisGeorge Kassiotis eLife Published 15 November 2019 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeLight MicroscopyCell ServicesFlow CytometryHigh Throughput ScreeningScientific computingBiological Research FacilityFull details
LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly Authors (9)Jan AttigGeorge YoungLou Hosie David Perkins Vesela Encheva-YokoyaJonathan StoyeBram Snijders Nicola TernetteGeorge Kassiotis Genome Research Published 1 October 2019 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeProteomicsPeptide ChemistryScientific computingFull details
Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity Authors (8) Ulf Dittmer Kathrin SutterGeorge Kassiotis Gennadiy Zelinskyy Zoltán Bánki Heribert Stoiber Mario L Santiago Kim J Hasenkrug FEMS Microbiology Reviews Published 1 September 2019 Crick labsGeorge KassiotisFull details
MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells Authors (8) Julia MerkenschlagerUrszula EksmondLuca DanelliJan AttigGeorge Young Carla NowosadPavel TolarGeorge Kassiotis Blood Published 30 January 2019 Crick labs/ facilitiesGeorge KassiotisJonathan StoyePavel TolarCell ServicesFlow CytometryHigh Throughput ScreeningBiological Research FacilityFull details
A protective role for the lectin CD169/Siglec-1 against a pathogenic murine retrovirus Authors (11) Pradeep D Uchil Ruoxi Pi Kelsey A Haugh Mark S Ladinsky John D Ventura Brad S Barrett Mario L Santiago Pamela J BjorkmanGeorge Kassiotis Xaver Sewald Walther Mothes Cell Host & Microbe Published 1 January 2019 Crick labsGeorge KassiotisFull details
Restoration of endogenous retrovirus infectivity impacts mouse cancer models Authors (10)Eleonora Ottina Prisca LevyUrszula Eksmond Julia MerkenschlagerGeorge Young Juliette RoelsJonathan Stoye Thomas TütingDinis CaladoGeorge Kassiotis Cancer Immunology Research Published 1 November 2018 Crick labs/ facilitiesDinis CaladoGeorge KassiotisJonathan StoyeFlow CytometryBiological Research FacilityFull details
Correlates of follicular helper bias in the CD4 T cell response to a retroviral antigen Authors (3)Luca Danelli T DonnarummaGeorge Kassiotis Frontiers in Immunology Published 29 June 2018 Crick labs/ facilitiesGeorge KassiotisFlow CytometryBiological Research FacilityFull details
Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells Authors (9) Martina Fontaine Isabel Vogel Yves-Rémi Van Eycke Adrien Galuppo Yousra Ajouaou Christine DecaesteckerGeorge Kassiotis Muriel Moser Oberdan Leo EMBO Journal Published 1 February 2018 Crick labsGeorge KassiotisFull details
Physiological and pathological transcriptional activation of endogenous retroelements assessed by RNA-sequencing of B lymphocytes Authors (4)Jan AttigGeorge YoungJonathan StoyeGeorge Kassiotis Frontiers in Microbiology Published 12 December 2017 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeScientific computingFull details
Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer Authors (2)George KassiotisJonathan Stoye Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Published 19 October 2017 Crick labsGeorge KassiotisJonathan StoyeFull details
Mutation of the putative immunosuppressive domain of the retroviral envelope glycoprotein compromises infectivity Authors (6)Urszula Eksmond Bryony Jenkins Julia Merkenschlager Walther MothesJonathan StoyeGeorge Kassiotis Journal of Virology Published 1 November 2017 Crick labs/ facilitiesGeorge KassiotisJonathan StoyeFlow CytometryBiological Research FacilityFull details
