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Numerous retroviral particles (pseudocoloured) endogenously produced by lymphoma cells in an immune-deficient mouse. Toggle to view hero caption George Kassiotis : Publications Lab MenuLab Menu Overview Areas of interest Publications Members Vacancy Breadcrumb Home Research Labs George Kassiotis Publications PublicationsYear published2020 (9)2019 (6)2018 (2)2017 (4)2016 (6)2015 (1)2014 (6)2013 (3)2012 (4)2011 (2)2010 (2) Facet Year publishedResearch topicsComputational & Systems Biology (28)Genetics & Genomics (28)Model Organisms (27)Immunology (26)Infectious Disease (16)Structural Biology & Biophysics (16)Chemical Biology & High Throughput (6)Signalling & Oncogenes (5)Stem Cells (5)Tumour Biology (5)Cell Biology (4)Cell Cycle & Chromosomes (4)Genome Integrity & Repair (4)Human Biology & Physiology (4)Metabolism (4)Biochemistry & Proteomics (3)Developmental Biology (3)Neurosciences (3)Imaging (2)Gene Expression (1)Microfabrication & Bioengineering (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (45)Primary research (35)Review (8)Letter (1)Method (1) Facet Publication typeJournalJournal of Immunology (7)PLOS Pathogens (3)Retrovirology (3)Frontiers in Immunology (2)Journal of Virology (2)Nature (2)BioEssays (1)Blood (1)Cancer Immunology Research (1)Cell Host & Microbe (1)Cell Reports (1)Cellular and Molecular Immunology (1)Current Opinion in Immunology (1)eLife (1)EMBO Journal (1)FEMS Microbiology Reviews (1)Frontiers in Microbiology (1)Genome Medicine: medicine in the post-genomic era (1)Genome Research (1)Immunity (1)Journal of Experimental Medicine (1)Journal of General Virology (1)Journal of Leukocyte Biology (1)Nature Biotechnology (1)Nature Communications (1)Nature Genetics (1)Nature Reviews Immunology (1)Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1)Science (1)Scientific Reports (1)The Lancet (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 20 of 45Last updated : 28 February 2021 02:46 Preexisting and de novo humoral immunity to SARS-CoV-2 in humans Authors (47)Kevin NgNikhil Faulkner Georgina H CornishAnnachiara Rosa Ruth Harvey Saira Hussain[...]Steve Gamblin Laura E MccoyPeter Cherepanov Eleni NastouliGeorge Kassiotis Science Published 11 December 2020 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryFlow CytometryHigh Throughput ScreeningCell ServicesFull details Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option Authors (9)Kevin NgJan Attig William BollandGeorge YoungJack MajorAntoni WrobelSteve GamblinAndreas WackGeorge Kassiotis Nature Genetics Published 1 December 2020 Crick labs/ facilitiesAndreas WackJonathan StoyeGeorge KassiotisSteve GamblinScientific computingFlow CytometryCell ServicesAdvanced SequencingFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan Lewer Gavin Kelly Judith Heaney[...] Andrew Hayward Richard GilsonGavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenomics/Equipment ParkFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Restriction of memory B cell differentiation at the germinal center B cell positive selection stage Authors (13) Amparo Toboso-Navasa Arief Gunawan Giulia Morlino Rinako Nakagawa Andrea Taddei Djamil Damry[...] Martin JanzGeorge Kassiotis Robert Brink Martin EilersDinis Calado Journal of Experimental Medicine Published 6 July 2020 Crick labs/ facilitiesGeorge KassiotisDinis CaladoBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen AmbroseSam BarrellRupert BealeGanka Bineva-ToddDhruva Biswas[...]Sophia Ward Wai Keong WongJoshua WrightMary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyPeptide ChemistryMetabolomicsHigh Throughput ScreeningGenomics/Equipment ParkFermentationAdvanced SequencingScientific computingFull details Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event Authors (5)Veera PanovaJan AttigGeorge YoungJonathan StoyeGeorge Kassiotis PLOS Pathogens Published 26 May 2020 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisFlow CytometryBiological Research FacilityFull details Default polyfunctional T helper 1 response to ample signal 1 alone Authors (4)Luca Danelli Georgina Cornish Julia MerkenschlagerGeorge Kassiotis Cellular and Molecular Immunology Published 20 April 2020 Crick labs/ facilitiesGeorge KassiotisFlow CytometryCell ServicesBiological Research FacilityFull details Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation Authors (12) Huipeng Jiao Laurens Wachsmuth Snehlata Kumari Robin Schwarzer Juan Lin Remzi Onur Eren[...] Rebecca LaneGeorge YoungGeorge Kassiotis William J Kaiser Manolis Pasparakis Nature Published 25 March 2020 Crick labsJonathan StoyeGeorge KassiotisFull details Regulatory T cells restrain interleukin-2- and Blimp-1-dependent acquisition of cytotoxic function by CD4+ T cells Authors (22) Anna Śledzińska Maria Vila de Mucha Katharina Bergerhoff Alastair Hotblack Dafne Franz Demane Ehsan Ghorani[...] Graham M Lord Hans Stauss Richard G Jenner Karl S Peggs Sergio A Quezada Immunity Published 14 January 2020 Crick labsGeorge KassiotisFull details Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression Authors (12)Anastasiya KazachenkaGeorge YoungJan Attig Chrysoula Kordella Eleftheria Lamprianidou Emmanuela Zoulia[...] Menelaos Papoutselis Elsa Bernard Elli Papaemmanuil Ioannis KotsianidisGeorge Kassiotis Genome Medicine: medicine in the post-genomic era Published 23 December 2019 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisScientific computingLight MicroscopyFlow CytometryCell ServicesFull details Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist Authors (7)Kevin NgJan AttigGeorge YoungEleonora Ottina Spyros I Papamichos Ioannis KotsianidisGeorge Kassiotis eLife Published 15 November 2019 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly Authors (9)Jan AttigGeorge YoungLou Hosie David Perkins Vesela Encheva-YokoyaJonathan StoyeBram Snijders Nicola TernetteGeorge Kassiotis Genome Research Published 1 October 2019 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisProteomicsScientific computingPeptide ChemistryFull details Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity Authors (8) Ulf Dittmer Kathrin SutterGeorge Kassiotis Gennadiy Zelinskyy Zoltán Bánki Heribert Stoiber Mario L Santiago Kim J Hasenkrug FEMS Microbiology Reviews Published 1 September 2019 Crick labsGeorge KassiotisFull details MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells Authors (8) Julia MerkenschlagerUrszula EksmondLuca DanelliJan AttigGeorge Young Carla NowosadPavel TolarGeorge Kassiotis Blood Published 30 January 2019 Crick labs/ facilitiesPavel TolarJonathan StoyeGeorge KassiotisHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details A protective role for the lectin CD169/Siglec-1 against a pathogenic murine retrovirus Authors (11) Pradeep D Uchil Ruoxi Pi Kelsey A Haugh Mark S Ladinsky John D Ventura Brad S Barrett Mario L Santiago Pamela J BjorkmanGeorge Kassiotis Xaver Sewald Walther Mothes Cell Host & Microbe Published 1 January 2019 Crick labsGeorge KassiotisFull details Restoration of endogenous retrovirus infectivity impacts mouse cancer models Authors (10)Eleonora Ottina Prisca LevyUrszula Eksmond Julia MerkenschlagerGeorge Young Juliette RoelsJonathan Stoye Thomas TütingDinis CaladoGeorge Kassiotis Cancer Immunology Research Published 1 November 2018 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisDinis CaladoFlow CytometryBiological Research FacilityFull details Correlates of follicular helper bias in the CD4 T cell response to a retroviral antigen Authors (3)Luca Danelli T DonnarummaGeorge Kassiotis Frontiers in Immunology Published 29 June 2018 Crick labs/ facilitiesGeorge KassiotisFlow CytometryBiological Research FacilityFull details Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells Authors (9) Martina Fontaine Isabel Vogel Yves-Rémi Van Eycke Adrien Galuppo Yousra Ajouaou Christine DecaesteckerGeorge Kassiotis Muriel Moser Oberdan Leo EMBO Journal Published 1 February 2018 Crick labsGeorge KassiotisFull details Physiological and pathological transcriptional activation of endogenous retroelements assessed by RNA-sequencing of B lymphocytes Authors (4)Jan AttigGeorge YoungJonathan StoyeGeorge Kassiotis Frontiers in Microbiology Published 12 December 2017 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisScientific computingFull details Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer Authors (2)George KassiotisJonathan Stoye Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Published 19 October 2017 Crick labsJonathan StoyeGeorge KassiotisFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans Authors (47)Kevin NgNikhil Faulkner Georgina H CornishAnnachiara Rosa Ruth Harvey Saira Hussain[...]Steve Gamblin Laura E MccoyPeter Cherepanov Eleni NastouliGeorge Kassiotis Science Published 11 December 2020 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryFlow CytometryHigh Throughput ScreeningCell ServicesFull details
Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option Authors (9)Kevin NgJan Attig William BollandGeorge YoungJack MajorAntoni WrobelSteve GamblinAndreas WackGeorge Kassiotis Nature Genetics Published 1 December 2020 Crick labs/ facilitiesAndreas WackJonathan StoyeGeorge KassiotisSteve GamblinScientific computingFlow CytometryCell ServicesAdvanced SequencingFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan Lewer Gavin Kelly Judith Heaney[...] Andrew Hayward Richard GilsonGavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenomics/Equipment ParkFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Restriction of memory B cell differentiation at the germinal center B cell positive selection stage Authors (13) Amparo Toboso-Navasa Arief Gunawan Giulia Morlino Rinako Nakagawa Andrea Taddei Djamil Damry[...] Martin JanzGeorge Kassiotis Robert Brink Martin EilersDinis Calado Journal of Experimental Medicine Published 6 July 2020 Crick labs/ facilitiesGeorge KassiotisDinis CaladoBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen AmbroseSam BarrellRupert BealeGanka Bineva-ToddDhruva Biswas[...]Sophia Ward Wai Keong WongJoshua WrightMary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyPeptide ChemistryMetabolomicsHigh Throughput ScreeningGenomics/Equipment ParkFermentationAdvanced SequencingScientific computingFull details
Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event Authors (5)Veera PanovaJan AttigGeorge YoungJonathan StoyeGeorge Kassiotis PLOS Pathogens Published 26 May 2020 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisFlow CytometryBiological Research FacilityFull details
Default polyfunctional T helper 1 response to ample signal 1 alone Authors (4)Luca Danelli Georgina Cornish Julia MerkenschlagerGeorge Kassiotis Cellular and Molecular Immunology Published 20 April 2020 Crick labs/ facilitiesGeorge KassiotisFlow CytometryCell ServicesBiological Research FacilityFull details
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation Authors (12) Huipeng Jiao Laurens Wachsmuth Snehlata Kumari Robin Schwarzer Juan Lin Remzi Onur Eren[...] Rebecca LaneGeorge YoungGeorge Kassiotis William J Kaiser Manolis Pasparakis Nature Published 25 March 2020 Crick labsJonathan StoyeGeorge KassiotisFull details
Regulatory T cells restrain interleukin-2- and Blimp-1-dependent acquisition of cytotoxic function by CD4+ T cells Authors (22) Anna Śledzińska Maria Vila de Mucha Katharina Bergerhoff Alastair Hotblack Dafne Franz Demane Ehsan Ghorani[...] Graham M Lord Hans Stauss Richard G Jenner Karl S Peggs Sergio A Quezada Immunity Published 14 January 2020 Crick labsGeorge KassiotisFull details
Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression Authors (12)Anastasiya KazachenkaGeorge YoungJan Attig Chrysoula Kordella Eleftheria Lamprianidou Emmanuela Zoulia[...] Menelaos Papoutselis Elsa Bernard Elli Papaemmanuil Ioannis KotsianidisGeorge Kassiotis Genome Medicine: medicine in the post-genomic era Published 23 December 2019 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisScientific computingLight MicroscopyFlow CytometryCell ServicesFull details
Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist Authors (7)Kevin NgJan AttigGeorge YoungEleonora Ottina Spyros I Papamichos Ioannis KotsianidisGeorge Kassiotis eLife Published 15 November 2019 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly Authors (9)Jan AttigGeorge YoungLou Hosie David Perkins Vesela Encheva-YokoyaJonathan StoyeBram Snijders Nicola TernetteGeorge Kassiotis Genome Research Published 1 October 2019 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisProteomicsScientific computingPeptide ChemistryFull details
Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity Authors (8) Ulf Dittmer Kathrin SutterGeorge Kassiotis Gennadiy Zelinskyy Zoltán Bánki Heribert Stoiber Mario L Santiago Kim J Hasenkrug FEMS Microbiology Reviews Published 1 September 2019 Crick labsGeorge KassiotisFull details
MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells Authors (8) Julia MerkenschlagerUrszula EksmondLuca DanelliJan AttigGeorge Young Carla NowosadPavel TolarGeorge Kassiotis Blood Published 30 January 2019 Crick labs/ facilitiesPavel TolarJonathan StoyeGeorge KassiotisHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
A protective role for the lectin CD169/Siglec-1 against a pathogenic murine retrovirus Authors (11) Pradeep D Uchil Ruoxi Pi Kelsey A Haugh Mark S Ladinsky John D Ventura Brad S Barrett Mario L Santiago Pamela J BjorkmanGeorge Kassiotis Xaver Sewald Walther Mothes Cell Host & Microbe Published 1 January 2019 Crick labsGeorge KassiotisFull details
Restoration of endogenous retrovirus infectivity impacts mouse cancer models Authors (10)Eleonora Ottina Prisca LevyUrszula Eksmond Julia MerkenschlagerGeorge Young Juliette RoelsJonathan Stoye Thomas TütingDinis CaladoGeorge Kassiotis Cancer Immunology Research Published 1 November 2018 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisDinis CaladoFlow CytometryBiological Research FacilityFull details
Correlates of follicular helper bias in the CD4 T cell response to a retroviral antigen Authors (3)Luca Danelli T DonnarummaGeorge Kassiotis Frontiers in Immunology Published 29 June 2018 Crick labs/ facilitiesGeorge KassiotisFlow CytometryBiological Research FacilityFull details
Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells Authors (9) Martina Fontaine Isabel Vogel Yves-Rémi Van Eycke Adrien Galuppo Yousra Ajouaou Christine DecaesteckerGeorge Kassiotis Muriel Moser Oberdan Leo EMBO Journal Published 1 February 2018 Crick labsGeorge KassiotisFull details
Physiological and pathological transcriptional activation of endogenous retroelements assessed by RNA-sequencing of B lymphocytes Authors (4)Jan AttigGeorge YoungJonathan StoyeGeorge Kassiotis Frontiers in Microbiology Published 12 December 2017 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisScientific computingFull details
Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer Authors (2)George KassiotisJonathan Stoye Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Published 19 October 2017 Crick labsJonathan StoyeGeorge KassiotisFull details
