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Breadcrumb George Kassiotis Kassiotis lab Retroviral Immunology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Numerous retroviral particles (pseudocoloured) endogenously produced by lymphoma cells in an immune-deficient mouse. Toggle to view hero caption PublicationsYear published2023 (1)2022 (2)2021 (8)2020 (2)2018 (1) Facet Year publishedResearch topicsChemical Biology & High Throughput (14)Computational & Systems Biology (14)Genetics & Genomics (14)Immunology (14)Model Organisms (14)Signalling & Oncogenes (14)Tumour Biology (14)Genome Integrity & Repair (13)Stem Cells (13)Structural Biology & Biophysics (13)Infectious Disease (12)Biochemistry & Proteomics (11)Cell Biology (11)Human Biology & Physiology (11)Metabolism (11)Cell Cycle & Chromosomes (9)Neurosciences (9)Imaging (5)Gene Expression (2)Synthetic Biology (2)Microfabrication & Bioengineering (1) (-)Developmental Biology (14) Facet Research topicsPublication typeJournal article (14)Primary research (12)Letter (1)Method (1) Facet Publication typeJournalNature Cancer (3)Cancer Cell (2)The Lancet (2)Cancer Immunology Research (1)Cell Reports Medicine (1)Journal of Experimental Medicine (1)Oncogene (1)Proceedings of the National Academy of Sciences of USA (1)Science advances (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 14 of 14Last updated : 25 April 2024 03:25 Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika FendlerEdward CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion Authors (15)Eleonora OttinaVeera PanovaLaura DoglioAnastasiya Kazachenka Georgina CornishJoanna Kirkpatrick[...] Peter Van LooCharles SwantonJames Macrae Thomas TütingGeorge Kassiotis Oncogene Published 16 September 2021 Crick labs/ facilitiesPeter Van LooCharles SwantonJonathan StoyeGeorge KassiotisProteomicsMetabolomicsScientific computingLight MicroscopyFlow CytometryCell ServicesBiological Research FacilityFull details SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Authors (40)Annachiara RosaVal Pye Carl Graham Luke Muir Jeffrey SeowKevin Ng[...] Richard S TedderGeorge Kassiotis Laura E Mccoy Katie J DooresPeter Cherepanov Science advances Published 28 May 2021 Crick labs/ facilitiesPeter RosenthalGeorge KassiotisSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsFlow CytometryFull details SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth Authors (11)Rinako Nakagawa Amparo Toboso-Navasa Marta SchipsGeorge Young Leena Bhaw-RosunMiriam Llorian Sopena Probir Chakravarty Abdul Karim SesayGeorge Kassiotis Michael Meyer-HermannDinis Calado Proceedings of the National Academy of Sciences of USA Published 12 January 2021 Crick labs/ facilitiesGeorge KassiotisDinis CaladoBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Restriction of memory B cell differentiation at the germinal center B cell positive selection stage Authors (13) Amparo Toboso-Navasa Arief Gunawan Giulia MorlinoRinako Nakagawa Andrea Taddei Djamil Damry[...] Martin JanzGeorge Kassiotis Robert Brink Martin EilersDinis Calado Journal of Experimental Medicine Published 6 July 2020 Crick labs/ facilitiesGeorge KassiotisDinis CaladoBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Restoration of endogenous retrovirus infectivity impacts mouse cancer models Authors (10)Eleonora Ottina Prisca LevyUrszula Eksmond Julia MerkenschlagerGeorge Young Juliette RoelsJonathan Stoye Thomas TütingDinis CaladoGeorge Kassiotis Cancer Immunology Research Published 1 November 2018 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisDinis CaladoFlow CytometryBiological Research FacilityFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika FendlerEdward CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion Authors (15)Eleonora OttinaVeera PanovaLaura DoglioAnastasiya Kazachenka Georgina CornishJoanna Kirkpatrick[...] Peter Van LooCharles SwantonJames Macrae Thomas TütingGeorge Kassiotis Oncogene Published 16 September 2021 Crick labs/ facilitiesPeter Van LooCharles SwantonJonathan StoyeGeorge KassiotisProteomicsMetabolomicsScientific computingLight MicroscopyFlow CytometryCell ServicesBiological Research FacilityFull details
SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Authors (40)Annachiara RosaVal Pye Carl Graham Luke Muir Jeffrey SeowKevin Ng[...] Richard S TedderGeorge Kassiotis Laura E Mccoy Katie J DooresPeter Cherepanov Science advances Published 28 May 2021 Crick labs/ facilitiesPeter RosenthalGeorge KassiotisSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsFlow CytometryFull details
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details
Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth Authors (11)Rinako Nakagawa Amparo Toboso-Navasa Marta SchipsGeorge Young Leena Bhaw-RosunMiriam Llorian Sopena Probir Chakravarty Abdul Karim SesayGeorge Kassiotis Michael Meyer-HermannDinis Calado Proceedings of the National Academy of Sciences of USA Published 12 January 2021 Crick labs/ facilitiesGeorge KassiotisDinis CaladoBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Restriction of memory B cell differentiation at the germinal center B cell positive selection stage Authors (13) Amparo Toboso-Navasa Arief Gunawan Giulia MorlinoRinako Nakagawa Andrea Taddei Djamil Damry[...] Martin JanzGeorge Kassiotis Robert Brink Martin EilersDinis Calado Journal of Experimental Medicine Published 6 July 2020 Crick labs/ facilitiesGeorge KassiotisDinis CaladoBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Restoration of endogenous retrovirus infectivity impacts mouse cancer models Authors (10)Eleonora Ottina Prisca LevyUrszula Eksmond Julia MerkenschlagerGeorge Young Juliette RoelsJonathan Stoye Thomas TütingDinis CaladoGeorge Kassiotis Cancer Immunology Research Published 1 November 2018 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisDinis CaladoFlow CytometryBiological Research FacilityFull details