In order to prevent, combat or repair defects that lead to disease it is vital that we understand how the macromolecular components of molecular machines assemble, function and co-operate with one another in order to carry out complex biological processes.
To understand how molecular machines function and perform their biological task we study molecular assemblies by applying structural, biophysical and biochemical methodologies. These approaches allow us to dissect a macromolecular complex, visualise the components and examine the interactions between the molecules that make up the complex. Current projects include analysis of the retroviral capsid assembly and the interaction with host factors (Ball et al 2016; Goldstone et al, 2014) and structural studies of host-cell anti retroviral restriction factors and retroviral accessory proteins (Goldstone et al, 2011; Schwefel et al 2014; Arnold et al, 2015).
- Macromolecular assemblies in transcriptional 3'-end processing
- Retroviral capsid assembly
- Mechanism of post-entry retroviral restriction factors
- Retroviral accessory proteins