Vacancies Find links to current vacancies, and information about recruitment to various types of role.
Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Francis Crick Institute coronavirus (COVID-19) response The Francis Crick Institute is working at the forefront of the scientific response to coronavirus, volunteering expertise and facilities to help tackle the COVID-19 pandemic.
Crystal structure of the Trim5α HIV-1 restriction factor. Toggle to view hero caption Ian Taylor : Publications Lab MenuLab Menu Overview Areas of interest Publications Members Vacancies Breadcrumb Home Research Labs Ian Taylor Publications PublicationsYear published2020 (3)2019 (6)2018 (3)2017 (7)2016 (5)2015 (5)2014 (6)2013 (1)2012 (2)2011 (5)2010 (4) Facet Year publishedResearch topicsInfectious Disease (27)Model Organisms (27)Structural Biology & Biophysics (27)Chemical Biology & High Throughput (10)Cell Biology (9)Genetics & Genomics (9)Biochemistry & Proteomics (8)Imaging (7)Computational & Systems Biology (5)Cell Cycle & Chromosomes (2)Genome Integrity & Repair (2)Immunology (2)Signalling & Oncogenes (2)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (47)Primary research (43)Review (3)Method (1) Facet Publication typeJournalNucleic Acids Research (5)PLOS Pathogens (4)Scientific Reports (4)Nature Communications (3)Proceedings of the National Academy of Sciences of the United States of America (3)Cell Host & Microbe (2)Cell Reports (2)EMBO Journal (2)Journal of Biological Chemistry (2)Nature (2)Retrovirology (2)Acta Crystallographica. Section B, Structural science (1)Antimicrobial Agents and Chemotherapy (1)Biochemical Journal (1)Biochemical Society Transactions (1)BMC Structural Biology (1)Current Opinion in Structural Biology (1)eLife (1)Journal of Molecular Biology (1)Methods in Molecular Biology (1)Plant Journal (1)PLOS Biology (1)PLOS ONE (1)Proteins (1)Science (1)Science advances (1)Viruses (1) Facet Journal Publications Displaying 1 - 20 of 47Last updated : 25 January 2021 02:55 Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis Authors (7)Liz MorrisSarah CaswellSimone Kunzelmann Laurence H Arnold Andrew G PurkissGeoff KellyIan Taylor Nature Communications Published 23 June 2020 Crick labs/ facilitiesIan TaylorStructural BiologyMRC Biomedical NMR CentreFull details The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability Authors (6)Johanna Roostalu Claire Thomas Nicholas Ian CadeSimone KunzelmannIan TaylorThomas Surrey eLife Published 13 February 2020 Crick labs/ facilitiesIan TaylorThomas SurreyStructural BiologyProteomicsFull details Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag Authors (5)Matthew Cottee Suzanne C LethamGeorge YoungJonathan StoyeIan Taylor Science advances Published 1 January 2020 Crick labsIan TaylorJonathan StoyeFull details Structural basis for Fullerene geometry in a human endogenous retrovirus capsid Authors (12)Oliver Acton Tim GrantGiuseppe Nicastro Neil J Ball David C Goldstone Laura E Robertson[...]Andrea Nans Andres RamosJonathan StoyeIan TaylorPeter Rosenthal Nature Communications Published 20 December 2019 Crick labs/ facilitiesIan TaylorJonathan StoyePeter RosenthalStructural BiologyMRC Biomedical NMR CentreFull details Positive selection in dNTPase SAMHD1 throughout mammalian evolution Authors (12) Christopher MonitLiz Morris Christopher RuisBart Szafran Grant ThiltgenChloe Tsai[...]Kate BishopJonathan StoyeIan Taylor Ariberto Fassati Richard A Goldstein Proceedings of the National Academy of Sciences of the United States of America Published 10 September 2019 Crick labsIan TaylorJonathan StoyeKate BishopFull details The missing link: allostery and catalysis in the anti-viral protein SAMHD1 Authors (2)Liz MorrisIan Taylor Biochemical Society Transactions Published 1 August 2019 Crick labsIan TaylorFull details Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery Authors (14) Avnish PatelAbi Perrin Helen R Flynn Claudine BissonChrislaine Withers-MartinezMoritz Treeck[...] Andres Ramos Tim W GilbergerBram SnijdersMike Blackman David A Baker PLOS Biology Published 10 May 2019 Crick labs/ facilitiesMoritz TreeckIan TaylorMike BlackmanProteomicsFull details IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties Authors (9) Robert Dagil Neil J BallRoksana Ogrodowicz Fruzsina Hobor Andrew G PurkissGeoff Kelly Stephen R MartinIan Taylor Andres Ramos Nucleic Acids Research Published 7 May 2019 Crick labs/ facilitiesIan TaylorMRC Biomedical NMR CentreStructural BiologyMRC Biomedical NMR CentreFull details Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain Authors (9) Xiankun Cheng Yanxiang Zhao Qingshan Jiang Jun Yang Wensheng ZhaoIan Taylor You-Liang Peng Dongli Wang Junfeng Liu Nucleic Acids Research Published 7 May 2019 Crick labsIan TaylorFull details A positive charged patch and stabilized hydrophobic core are essential for avirulence function of AvrPib in the rice blast fungus Authors (9) Xin Zhang Dan He Yanxiang Zhao Xilan Cheng Wensheng ZhaoIan Taylor Jun Yang Junfeng Liu You-Liang Peng Plant Journal Published 1 August 2018 Crick labsIan TaylorFull details Structure based function-annotation of hypothetical protein MGG_01005 from Magnaporthe oryzae reveals it is the dynein light chain orthologue of dynlt1/3 Authors (9) Guorui Li Jinguang Huang Jun Yang Dan He Chao Wang Xiaoxuan QiIan Taylor Junfeng Liu You-Liang Peng Scientific Reports Published 2 March 2018 Crick labsIan TaylorFull details A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets Authors (12) Fruzsina Hobor Andre Dallmann Neil J Ball Carla Cicchini Cecilia BattistelliRoksana Ogrodowicz[...] Stephen R Martin Alfredo Castello Marco TripodiIan Taylor Andres Ramos Nature Communications Published 26 February 2018 Crick labs/ facilitiesIan TaylorStructural BiologyMRC Biomedical NMR CentreFull details DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages Authors (5) Petra MlcochovaSarah CaswellIan Taylor Greg J Towers Ravindra K Gupta EMBO Journal Published 30 October 2017 Crick labsIan TaylorFull details A comparative analysis of the foamy and ortho virus capsid structures reveals an ancient domain duplication Authors (3)Willie TaylorJonathan StoyeIan Taylor BMC Structural Biology Published 4 April 2017 Crick labsWillie TaylorIan TaylorJonathan StoyeFull details An RRM-ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion Authors (9) Katherine M Collins Yaroslav A Kainov Evangelos Christodoulou Debashish Ray Quaid Morris Timothy HughesIan Taylor Eugene V Makeyev Andres Ramos Nucleic Acids Research Published 20 June 2017 Crick labs/ facilitiesIan TaylorStructural BiologyMRC Biomedical NMR CentreFull details SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells Authors (9)Paula OrdonezSimone Kunzelmann Harriet CT GroomMelvyn Yap Simon Weising Chris MeierKate BishopIan TaylorJonathan Stoye Scientific Reports Published 21 February 2017 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details Mechanism of β-actin mRNA recognition by ZBP1 Authors (8)Giuseppe Nicastro Adela M Candel Michael UhlAlain Oregioni David Hollingworth Rolf Backofen Stephen R Martin Andres Ramos Cell Reports Published 31 January 2017 Crick labs/ facilitiesIan TaylorMRC Biomedical NMR CentreStructural BiologyMRC Biomedical NMR CentreProteomicsFull details New insights into the GINS complex explain the controversy between existing structural models Authors (10) Marta Carroni Matteo De March Barbara Medagli Ivet KrastanovaIan Taylor Heinz Amenitsch Hiroyuchi Araki Francesca M Pisani Ardan Patwardhan Silvia Onesti Scientific Reports Published 10 January 2017 Crick labsIan TaylorFull details A supramolecular assembly mediates lentiviral DNA integration Authors (14)Allison Ballandras-Colas Daniel P Maskell Erik SerraoJulia Locke Paolo Swuec Stefán R Jónsson[...]Ian Taylor Valgerdur Andrésdóttir Alan N EngelmanAlessandro CostaPeter Cherepanov Science Published 6 January 2017 Crick labs/ facilitiesIan TaylorAlessandro CostaPeter Cherepanov Structural BiologyElectron MicroscopyFull details Eleventh International Foamy Virus Conference—meeting report Authors (14) Florence Buseyne Antoine Gessain Marcelo A Soares André F Santos Magdalena Materniak-Kornas Pascale Lesage[...] Dirk Lindemann Birgitta M WöhrlJonathan StoyeIan Taylor Arifa S Khan Viruses Published 23 November 2016 Crick labsIan TaylorJonathan StoyeFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis Authors (7)Liz MorrisSarah CaswellSimone Kunzelmann Laurence H Arnold Andrew G PurkissGeoff KellyIan Taylor Nature Communications Published 23 June 2020 Crick labs/ facilitiesIan TaylorStructural BiologyMRC Biomedical NMR CentreFull details
The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability Authors (6)Johanna Roostalu Claire Thomas Nicholas Ian CadeSimone KunzelmannIan TaylorThomas Surrey eLife Published 13 February 2020 Crick labs/ facilitiesIan TaylorThomas SurreyStructural BiologyProteomicsFull details
Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag Authors (5)Matthew Cottee Suzanne C LethamGeorge YoungJonathan StoyeIan Taylor Science advances Published 1 January 2020 Crick labsIan TaylorJonathan StoyeFull details
Structural basis for Fullerene geometry in a human endogenous retrovirus capsid Authors (12)Oliver Acton Tim GrantGiuseppe Nicastro Neil J Ball David C Goldstone Laura E Robertson[...]Andrea Nans Andres RamosJonathan StoyeIan TaylorPeter Rosenthal Nature Communications Published 20 December 2019 Crick labs/ facilitiesIan TaylorJonathan StoyePeter RosenthalStructural BiologyMRC Biomedical NMR CentreFull details
Positive selection in dNTPase SAMHD1 throughout mammalian evolution Authors (12) Christopher MonitLiz Morris Christopher RuisBart Szafran Grant ThiltgenChloe Tsai[...]Kate BishopJonathan StoyeIan Taylor Ariberto Fassati Richard A Goldstein Proceedings of the National Academy of Sciences of the United States of America Published 10 September 2019 Crick labsIan TaylorJonathan StoyeKate BishopFull details
The missing link: allostery and catalysis in the anti-viral protein SAMHD1 Authors (2)Liz MorrisIan Taylor Biochemical Society Transactions Published 1 August 2019 Crick labsIan TaylorFull details
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery Authors (14) Avnish PatelAbi Perrin Helen R Flynn Claudine BissonChrislaine Withers-MartinezMoritz Treeck[...] Andres Ramos Tim W GilbergerBram SnijdersMike Blackman David A Baker PLOS Biology Published 10 May 2019 Crick labs/ facilitiesMoritz TreeckIan TaylorMike BlackmanProteomicsFull details
IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties Authors (9) Robert Dagil Neil J BallRoksana Ogrodowicz Fruzsina Hobor Andrew G PurkissGeoff Kelly Stephen R MartinIan Taylor Andres Ramos Nucleic Acids Research Published 7 May 2019 Crick labs/ facilitiesIan TaylorMRC Biomedical NMR CentreStructural BiologyMRC Biomedical NMR CentreFull details
Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain Authors (9) Xiankun Cheng Yanxiang Zhao Qingshan Jiang Jun Yang Wensheng ZhaoIan Taylor You-Liang Peng Dongli Wang Junfeng Liu Nucleic Acids Research Published 7 May 2019 Crick labsIan TaylorFull details
A positive charged patch and stabilized hydrophobic core are essential for avirulence function of AvrPib in the rice blast fungus Authors (9) Xin Zhang Dan He Yanxiang Zhao Xilan Cheng Wensheng ZhaoIan Taylor Jun Yang Junfeng Liu You-Liang Peng Plant Journal Published 1 August 2018 Crick labsIan TaylorFull details
Structure based function-annotation of hypothetical protein MGG_01005 from Magnaporthe oryzae reveals it is the dynein light chain orthologue of dynlt1/3 Authors (9) Guorui Li Jinguang Huang Jun Yang Dan He Chao Wang Xiaoxuan QiIan Taylor Junfeng Liu You-Liang Peng Scientific Reports Published 2 March 2018 Crick labsIan TaylorFull details
A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets Authors (12) Fruzsina Hobor Andre Dallmann Neil J Ball Carla Cicchini Cecilia BattistelliRoksana Ogrodowicz[...] Stephen R Martin Alfredo Castello Marco TripodiIan Taylor Andres Ramos Nature Communications Published 26 February 2018 Crick labs/ facilitiesIan TaylorStructural BiologyMRC Biomedical NMR CentreFull details
DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages Authors (5) Petra MlcochovaSarah CaswellIan Taylor Greg J Towers Ravindra K Gupta EMBO Journal Published 30 October 2017 Crick labsIan TaylorFull details
A comparative analysis of the foamy and ortho virus capsid structures reveals an ancient domain duplication Authors (3)Willie TaylorJonathan StoyeIan Taylor BMC Structural Biology Published 4 April 2017 Crick labsWillie TaylorIan TaylorJonathan StoyeFull details
An RRM-ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion Authors (9) Katherine M Collins Yaroslav A Kainov Evangelos Christodoulou Debashish Ray Quaid Morris Timothy HughesIan Taylor Eugene V Makeyev Andres Ramos Nucleic Acids Research Published 20 June 2017 Crick labs/ facilitiesIan TaylorStructural BiologyMRC Biomedical NMR CentreFull details
SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells Authors (9)Paula OrdonezSimone Kunzelmann Harriet CT GroomMelvyn Yap Simon Weising Chris MeierKate BishopIan TaylorJonathan Stoye Scientific Reports Published 21 February 2017 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details
Mechanism of β-actin mRNA recognition by ZBP1 Authors (8)Giuseppe Nicastro Adela M Candel Michael UhlAlain Oregioni David Hollingworth Rolf Backofen Stephen R Martin Andres Ramos Cell Reports Published 31 January 2017 Crick labs/ facilitiesIan TaylorMRC Biomedical NMR CentreStructural BiologyMRC Biomedical NMR CentreProteomicsFull details
New insights into the GINS complex explain the controversy between existing structural models Authors (10) Marta Carroni Matteo De March Barbara Medagli Ivet KrastanovaIan Taylor Heinz Amenitsch Hiroyuchi Araki Francesca M Pisani Ardan Patwardhan Silvia Onesti Scientific Reports Published 10 January 2017 Crick labsIan TaylorFull details
A supramolecular assembly mediates lentiviral DNA integration Authors (14)Allison Ballandras-Colas Daniel P Maskell Erik SerraoJulia Locke Paolo Swuec Stefán R Jónsson[...]Ian Taylor Valgerdur Andrésdóttir Alan N EngelmanAlessandro CostaPeter Cherepanov Science Published 6 January 2017 Crick labs/ facilitiesIan TaylorAlessandro CostaPeter Cherepanov Structural BiologyElectron MicroscopyFull details
Eleventh International Foamy Virus Conference—meeting report Authors (14) Florence Buseyne Antoine Gessain Marcelo A Soares André F Santos Magdalena Materniak-Kornas Pascale Lesage[...] Dirk Lindemann Birgitta M WöhrlJonathan StoyeIan Taylor Arifa S Khan Viruses Published 23 November 2016 Crick labsIan TaylorJonathan StoyeFull details
