Publications

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1

Authors (8)

Nature Communications

Published 26 October 2023

Crick labs/ facilities

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Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells

Authors (9)

Chloe Tsai
Sarah Caswell
Liz Morris
Melanie C Mann
Simon Pennell
Geoff Kelly
Harriet CT Groom
Ian Taylor
Kate Bishop

Retrovirology

Published 1 May 2023

Crick labs/ facilities

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The drug-induced interface that drives HIV-1 integrase hypermultimerization and loss of function

Authors (15)

Matthew Singer
Tung Dinh
Lev Levintov
Arun S Annamalai
Juan S Rey
Lorenzo Briganti
[...]
Alan N Engelman
Baek Kim
Juan R Perilla
Mamuka Kvaratskhelia
Peter Cherepanov

mBio

Published 1 February 2023

Crick labs/ facilities

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Multivalent interactions essential for lentiviral integrase function

Authors (20)

Allison Ballandras-Colas
Vidya Chivukula
Dominika Gruszka
Zelin Shan
Parmit K Singh
Val Pye
[...]
Ian Taylor
Dmitry Lyumkis
Hasan Yardimci
Alan N Engelman
Peter Cherepanov

Nature Communications

Published 3 May 2022

Crick labs/ facilities

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HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

Authors (6)

Anabel Guedan
Callum D Donaldson
Eve Caroe
Ophélie Cosnefroy
Ian Taylor
Kate Bishop

PLOS Pathogens

Published 20 September 2021

Crick labs/ facilities

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Structural characterisation of the Chaetomium thermophilum Chl1 helicase

Authors (8)

PLOS ONE

Published 10 May 2021

Crick labs/ facilities

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Positive selection in dNTPase SAMHD1 throughout mammalian evolution

Authors (12)

Christopher Monit
Liz Morris
Christopher Ruis
Bart Szafran
Grant Thiltgen
Chloe Tsai
[...]
Kate Bishop
Jonathan Stoye
Ian Taylor
Ariberto Fassati
Richard A Goldstein

Proceedings of the National Academy of Sciences of the United States of America

Published 10 September 2019

Crick labs

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Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

Authors (14)

Avnish Patel
Abigail Perrin
Helen R Flynn
Claudine Bisson
Chrislaine Withers-Martinez
Moritz Treeck
[...]
Andres Ramos
Tim W Gilberger
Bram Snijders
Michael Blackman
David A Baker

PLOS Biology

Published 10 May 2019

Crick labs/ facilities

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SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells

Authors (9)

Scientific Reports

Published 21 February 2017

Crick labs/ facilities

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A supramolecular assembly mediates lentiviral DNA integration

Authors (14)

Allison Ballandras-Colas
Daniel P Maskell
Erik Serrao
Julia Locke
Paolo Swuec
Stefán R Jónsson
[...]
Ian Taylor
Valgerdur Andrésdóttir
Alan N Engelman
Alessandro Costa
Peter Cherepanov

Science

Published 6 January 2017

Crick labs/ facilities

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Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity

Authors (5)

Marios G Koliopoulos
Diego Esposito
Evangelos Christodoulou
Ian Taylor
Katrin Rittinger

EMBO Journal

Published 1 June 2016

Crick labs/ facilities

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Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction

Authors (15)

Laurence H Arnold
Harriet CT Groom
Simone Kunzelmann
David Schwefel
Sarah Caswell
Paula Ordonez Suarez
[...]
Steven A Howell
Jonathan Stoye
Michelle Webb
Ian Taylor
Kate Bishop

PLOS Pathogens

Published 2 October 2015

Crick labs/ facilities

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Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx

Authors (7)

David Schwefel
Virginie C Boucherit
Evangelos Christodoulou
Philip Walker
Jonathan Stoye
Kate Bishop
Ian Taylor

Cell Host & Microbe

Published 8 April 2015

Crick labs/ facilities

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A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1

Authors (4)

Laurence H Arnold
Simone Kunzelmann
Martin R Webb
Ian Taylor

Antimicrobial Agents and Chemotherapy

Published 1 January 2015

Crick labs/ facilities

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Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells

The drug-induced interface that drives HIV-1 integrase hypermultimerization and loss of function

Multivalent interactions essential for lentiviral integrase function

HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

Structural characterisation of the Chaetomium thermophilum Chl1 helicase

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

Positive selection in dNTPase SAMHD1 throughout mammalian evolution

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells

A supramolecular assembly mediates lentiviral DNA integration

Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity

Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction

Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx

A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1

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