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Breadcrumb Ilaria Malanchi Malanchi lab Tumour-Host Interaction Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Lung metastasis: neutrophils (shown in brown) are a type of immune cells helping breast cancer cells to grow in the lung. Toggle to view hero caption PublicationsYear published2023 (4)2022 (8)2021 (3)2020 (5)2019 (5)2018 (1)2017 (2)2016 (2)2015 (3)2014 (1)2013 (1)2012 (1) Facet Year publishedResearch topicsGenetics & Genomics (33)Model Organisms (33)Stem Cells (33)Tumour Biology (33)Computational & Systems Biology (12)Genome Integrity & Repair (12)Chemical Biology & High Throughput (10)Gene Expression (8)Human Biology & Physiology (6)Cell Biology (4)Imaging (4)Immunology (3)Signalling & Oncogenes (3)Biochemistry & Proteomics (2)Developmental Biology (2)Infectious Disease (2)Cell Cycle & Chromosomes (1)Metabolism (1)Neurosciences (1)Structural Biology & Biophysics (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (36)Primary research (22)Review (8)Commentary (4)Method (2) Facet Publication typeJournalNature (6)Nature Communications (3)Cell Reports (2)Developmental Cell (2)Nature Cancer (2)Nature Cell Biology (2)Biochimica et Biophysica Acta (1)BoneKEy Reports (1)Breast Cancer Research (1)Cancer Cell (1)Cancer Letters (1)Cell (1)Cold Spring Harbor Perspectives in Medicine (1)Critical Reviews in Oncogenesis (1)Development (1)EMBO Journal (1)iScience (1)Journal of Clinical Medicine (1)Journal of Experimental Medicine (1)Nature Protocols (1)Nature Reviews Immunology (1)Scientific Reports (1)Seminars in Immunology (1)STAR Protocols (1)Trends in Cell Biology (1) Facet Journal Publications Displaying 1 - 20 of 36Last updated : 09 December 2023 03:20 Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes Authors (9)Anisha Ramessur Bana AmbasagerIker Valle AramburuFreddie Peakman Kelly Gleason Christoph LehmannVenizelos Papayannopoulos Raoul Charles CoombesIlaria Malanchi Breast Cancer Research Published 19 October 2023 Crick labs/ facilitiesVenizelos PapayannopoulosIlaria MalanchiFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details Mechanisms of organ-specific metastasis of breast cancer Authors (3)Emma Nolan Yibin KangIlaria Malanchi Cold Spring Harbor Perspectives in Medicine Published 1 November 2023 Crick labsIlaria MalanchiFull details A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling Authors (50) Patricia Altea-Manzano Ginevra Doglioni Yawen Liu Alejandro M CuadrosEmma Nolan Juan Fernández-García[...] Thomas GP Grünewald Uri Ben-David Christine DesmedtIlaria Malanchi Sarah-Maria Fendt Nature Cancer Published 1 March 2023 Crick labsIlaria MalanchiFull details Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells Authors (15) Anne Cuypers Laure-Anne TeuwenVicky Bridgeman Laura PMH de Rooij Guy Eelen Mieke Dewerchin[...] An Carton Ann Manderveld Peter B Vermeulen Andrew R Reynolds Peter Carmeliet STAR Protocols Published 16 December 2022 Crick labsIlaria MalanchiFull details Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth Authors (7)Anna Perdrix Rosell Oscar Maiques Joshua Alexander James Martin Probir ChakravartyLuigi Ombrato Victoria Sanz-MorenoIlaria Malanchi Cancer Letters Published 28 September 2022 Crick labs/ facilitiesIlaria MalanchiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details GREM1 is required to maintain cellular heterogeneity in pancreatic cancer Authors (21) Linxiang Lan Theodore Evan Huafu Li Aasia Hussain E Josue Ruiz May Zaw Thin[...]Emma Nye Yulong He Changhua Zhang Anguraj SadanandamAxel Behrens Nature Published 7 July 2022 Crick labs/ facilitiesIlaria MalanchiGeorge KassiotisAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Reflected stemness as a potential driver of the tumour microenvironment Authors (3)Felipe RodriguesFrancesca CiccarelliIlaria Malanchi Trends in Cell Biology Published 1 December 2022 Crick labsIlaria MalanchiFrancesca CiccarelliFull details Neutrophil phenotypes and functions in cancer: A consensus statement Authors (25) Daniela F Quail Borko Amulic Monowar Aziz Betsy J Barnes Evgeniy Eruslanov Zvi G Fridlender[...] Ping Wang Arturo Zychlinsky Karin E de Visser Mikala Egeblad Paul Kubes Journal of Experimental Medicine Published 6 June 2022 Crick labsIlaria MalanchiFull details Connecting the dots: Neutrophils at the interface of tissue regeneration and cancer Authors (2)Emma NolanIlaria Malanchi Seminars in Immunology Published 1 October 2021 Crick labsIlaria MalanchiFull details Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick RabasCeline Angeli Natascha Sewnath[...]Felipe RodriguesStuart HorswellPeter FaullRebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Clone competition as a mechanism to reduce tumor formation Authors (3)Amelia AchaIlaria MalanchiFrancesca Ciccarelli Developmental Cell Published 20 December 2021 Crick labsIlaria MalanchiFrancesca CiccarelliFull details Neutrophils in cancer: heterogeneous and multifaceted Authors (2) Catherine C HedrickIlaria Malanchi Nature Reviews Immunology Published 1 March 2022 Crick labsIlaria MalanchiFull details Integrated OMICs unveil the bone-marrow microenvironment in human leukemia Authors (13)Diana PassaroManuel Garcia Albornoz Giovanni Diana Probir ChakravartyLinda Ariza-McnaughtonAntoniana Batsivari[...]Alexander WaclawiczekLuigi OmbratoIlaria Malanchi John GribbenDominique Bonnet Cell Reports Published 11 May 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetBioinformatics and BiostatisticsProteomicsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Generation of neighbor-labeling cells to study intercellular interactions in vivo Authors (10)Luigi OmbratoEmma NolanDiana Passaro Ivana KurelacVicky BridgemanAlexander Waclawiczek Delfim Duarte Cristina Lo CelsoDominique BonnetIlaria Malanchi Nature Protocols Published 1 February 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion Authors (17) Irene Rodriguez-Hernandez Oscar Maiques Leonie Kohlhammer Gaia CantelliAnna Perdrix Rosell Joanne Monger[...] Xavier Matias-Guiu Gilbert O Fruhwirth Jose L OrgazIlaria Malanchi Victoria Sanz-Moreno Nature Communications Published 20 October 2020 Crick labsIlaria MalanchiFull details Early neutrophil responses to chemical carcinogenesis shape long-term lung cancer susceptibility Authors (4) Stefanie K WculekVicky BridgemanFreddie PeakmanIlaria Malanchi iScience Published 24 July 2020 Crick labs/ facilitiesIlaria MalanchiFlow CytometryExperimental HistopathologyBiological Research FacilityFull details Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate Authors (2)Emma NolanIlaria Malanchi Nature Published 2 July 2020 Crick labsIlaria MalanchiFull details Myosin II reactivation and cytoskeletal remodeling as a hallmark and a vulnerability in melanoma therapy resistance Authors (19) JL Orgaz E Crosas-Molist A SadokAnna Perdrix Rosell O Maiques I Rodriguez-Hernandez[...] F Wallberg C Tape SN KaragiannisIlaria Malanchi V Sanz-Moreno Cancer Cell Published 13 January 2020 Crick labsIlaria MalanchiFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on 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Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes Authors (9)Anisha Ramessur Bana AmbasagerIker Valle AramburuFreddie Peakman Kelly Gleason Christoph LehmannVenizelos Papayannopoulos Raoul Charles CoombesIlaria Malanchi Breast Cancer Research Published 19 October 2023 Crick labs/ facilitiesVenizelos PapayannopoulosIlaria MalanchiFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details
Mechanisms of organ-specific metastasis of breast cancer Authors (3)Emma Nolan Yibin KangIlaria Malanchi Cold Spring Harbor Perspectives in Medicine Published 1 November 2023 Crick labsIlaria MalanchiFull details
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling Authors (50) Patricia Altea-Manzano Ginevra Doglioni Yawen Liu Alejandro M CuadrosEmma Nolan Juan Fernández-García[...] Thomas GP Grünewald Uri Ben-David Christine DesmedtIlaria Malanchi Sarah-Maria Fendt Nature Cancer Published 1 March 2023 Crick labsIlaria MalanchiFull details
Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells Authors (15) Anne Cuypers Laure-Anne TeuwenVicky Bridgeman Laura PMH de Rooij Guy Eelen Mieke Dewerchin[...] An Carton Ann Manderveld Peter B Vermeulen Andrew R Reynolds Peter Carmeliet STAR Protocols Published 16 December 2022 Crick labsIlaria MalanchiFull details
Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth Authors (7)Anna Perdrix Rosell Oscar Maiques Joshua Alexander James Martin Probir ChakravartyLuigi Ombrato Victoria Sanz-MorenoIlaria Malanchi Cancer Letters Published 28 September 2022 Crick labs/ facilitiesIlaria MalanchiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
GREM1 is required to maintain cellular heterogeneity in pancreatic cancer Authors (21) Linxiang Lan Theodore Evan Huafu Li Aasia Hussain E Josue Ruiz May Zaw Thin[...]Emma Nye Yulong He Changhua Zhang Anguraj SadanandamAxel Behrens Nature Published 7 July 2022 Crick labs/ facilitiesIlaria MalanchiGeorge KassiotisAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Reflected stemness as a potential driver of the tumour microenvironment Authors (3)Felipe RodriguesFrancesca CiccarelliIlaria Malanchi Trends in Cell Biology Published 1 December 2022 Crick labsIlaria MalanchiFrancesca CiccarelliFull details
Neutrophil phenotypes and functions in cancer: A consensus statement Authors (25) Daniela F Quail Borko Amulic Monowar Aziz Betsy J Barnes Evgeniy Eruslanov Zvi G Fridlender[...] Ping Wang Arturo Zychlinsky Karin E de Visser Mikala Egeblad Paul Kubes Journal of Experimental Medicine Published 6 June 2022 Crick labsIlaria MalanchiFull details
Connecting the dots: Neutrophils at the interface of tissue regeneration and cancer Authors (2)Emma NolanIlaria Malanchi Seminars in Immunology Published 1 October 2021 Crick labsIlaria MalanchiFull details
Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick RabasCeline Angeli Natascha Sewnath[...]Felipe RodriguesStuart HorswellPeter FaullRebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Clone competition as a mechanism to reduce tumor formation Authors (3)Amelia AchaIlaria MalanchiFrancesca Ciccarelli Developmental Cell Published 20 December 2021 Crick labsIlaria MalanchiFrancesca CiccarelliFull details
Neutrophils in cancer: heterogeneous and multifaceted Authors (2) Catherine C HedrickIlaria Malanchi Nature Reviews Immunology Published 1 March 2022 Crick labsIlaria MalanchiFull details
Integrated OMICs unveil the bone-marrow microenvironment in human leukemia Authors (13)Diana PassaroManuel Garcia Albornoz Giovanni Diana Probir ChakravartyLinda Ariza-McnaughtonAntoniana Batsivari[...]Alexander WaclawiczekLuigi OmbratoIlaria Malanchi John GribbenDominique Bonnet Cell Reports Published 11 May 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetBioinformatics and BiostatisticsProteomicsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Generation of neighbor-labeling cells to study intercellular interactions in vivo Authors (10)Luigi OmbratoEmma NolanDiana Passaro Ivana KurelacVicky BridgemanAlexander Waclawiczek Delfim Duarte Cristina Lo CelsoDominique BonnetIlaria Malanchi Nature Protocols Published 1 February 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion Authors (17) Irene Rodriguez-Hernandez Oscar Maiques Leonie Kohlhammer Gaia CantelliAnna Perdrix Rosell Joanne Monger[...] Xavier Matias-Guiu Gilbert O Fruhwirth Jose L OrgazIlaria Malanchi Victoria Sanz-Moreno Nature Communications Published 20 October 2020 Crick labsIlaria MalanchiFull details
Early neutrophil responses to chemical carcinogenesis shape long-term lung cancer susceptibility Authors (4) Stefanie K WculekVicky BridgemanFreddie PeakmanIlaria Malanchi iScience Published 24 July 2020 Crick labs/ facilitiesIlaria MalanchiFlow CytometryExperimental HistopathologyBiological Research FacilityFull details
Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate Authors (2)Emma NolanIlaria Malanchi Nature Published 2 July 2020 Crick labsIlaria MalanchiFull details
Myosin II reactivation and cytoskeletal remodeling as a hallmark and a vulnerability in melanoma therapy resistance Authors (19) JL Orgaz E Crosas-Molist A SadokAnna Perdrix Rosell O Maiques I Rodriguez-Hernandez[...] F Wallberg C Tape SN KaragiannisIlaria Malanchi V Sanz-Moreno Cancer Cell Published 13 January 2020 Crick labsIlaria MalanchiFull details