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Breadcrumb Ilaria Malanchi Malanchi lab Tumour-Host Interaction Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Lung metastasis: neutrophils (shown in brown) are a type of immune cells helping breast cancer cells to grow in the lung. Toggle to view hero caption PublicationsYear published2024 (1)2023 (1)2022 (4)2021 (1)2019 (1)2016 (2)2015 (1) Facet Year publishedResearch topicsComputational & Systems Biology (11)Genetics & Genomics (11)Genome Integrity & Repair (11)Model Organisms (11)Stem Cells (11)Tumour Biology (11)Gene Expression (7)Cell Biology (5)Human Biology & Physiology (5)Signalling & Oncogenes (4)Imaging (3)Immunology (3)Biochemistry & Proteomics (2)Developmental Biology (2)Metabolism (2)Cell Cycle & Chromosomes (1)Infectious Disease (1)Neurosciences (1)Structural Biology & Biophysics (1)Synthetic Biology (1) (-)Chemical Biology & High Throughput (11) Facet Research topicsPublication typeJournal article (11)Primary research (10)Review (1) Facet Publication typeJournalNature (3)Cell Reports (2)Cancer Letters (1)Cell (1)Development (1)Nature Cancer (1)Nature Cell Biology (1)Nature Communications (1) Facet Journal Publications Displaying 1 - 11 of 11Last updated : 25 April 2024 02:39 Embracing cancer complexity: Hallmarks of systemic disease Authors (33)Charles Swanton Elsa Bernard Chris Abbosh Fabrice André Johan Auwerx Allan Balmain[...] Eileen White Frank Winkler John N WoodKaren Vousden Douglas Hanahan Cell Published 28 March 2024 Crick labsKaren VousdenCharles SwantonIlaria MalanchiGerard EvanFull details Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth Authors (7)Anna Perdrix Rosell Oscar Maiques Joshua Alexander James Martin Probir ChakravartyLuigi Ombrato Victoria Sanz-MorenoIlaria Malanchi Cancer Letters Published 28 September 2022 Crick labs/ facilitiesIlaria MalanchiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details GREM1 is required to maintain cellular heterogeneity in pancreatic cancer Authors (21) Linxiang Lan Theodore Evan Huafu Li Aasia Hussain E Josue Ruiz May Zaw Thin[...]Emma Nye Yulong He Changhua Zhang Anguraj SadanandamAxel Behrens Nature Published 7 July 2022 Crick labs/ facilitiesIlaria MalanchiGeorge KassiotisAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick Rabas Celine Angeli Natascha Sewnath[...]Felipe Rodrigues Stuart HorswellPeter Faull Rebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Integrated OMICs unveil the bone-marrow microenvironment in human leukemia Authors (13)Diana PassaroManuel Garcia Albornoz Giovanni Diana Probir ChakravartyLinda Ariza-McnaughtonAntoniana Batsivari[...]Alexander WaclawiczekLuigi OmbratoIlaria Malanchi John GribbenDominique Bonnet Cell Reports Published 11 May 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetBioinformatics and BiostatisticsProteomicsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Metastatic-niche labelling reveals parenchymal cells with stem features Authors (18)Luigi OmbratoEmma Nolan Ivana Kurelac Antranik MavousianVicky Bridgeman Ivonne Heinze[...] Valerie SpeirsLucy Collinson Alessandro Ori Joo-Hyeon LeeIlaria Malanchi Nature Published 28 August 2019 Crick labs/ facilitiesIlaria MalanchiElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours Authors (19) Leander Blaas Fabio PucciHendrik Messal Agneta B Andersson E Josue Ruiz Marco Gerling[...] Jos Jonkers Gordon StampIlaria Malanchi Rune ToftgårdAxel Behrens Nature Cell Biology Published 1 December 2016 Crick labs/ facilitiesIlaria MalanchiAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Integrin signalling regulates YAP and TAZ to control skin homeostasis Authors (16)Ahmed Elbediwy ZI Vincent-Mistiaen B Spencer-DeneRichard StoneStefan Boeing SK Wculek[...] H GerhardtAxel BehrensIlaria Malanchi OJ Sansom BJ Thompson Development Published 15 May 2016 Crick labs/ facilitiesBarry ThompsonErik SahaiIlaria MalanchiAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsFull details Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization Authors (11) Yaiza del Pozo MartinDanielle ParkAnassuya RamachandranLuigi Ombrato Fernando Calvo Probir Chakravarty Bradley Spencer-Dene Stefanie DerzsiCaroline HillErik SahaiIlaria Malanchi Cell Reports Published 22 December 2015 Crick labs/ facilitiesErik SahaiIlaria MalanchiCaroline HillExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Embracing cancer complexity: Hallmarks of systemic disease Authors (33)Charles Swanton Elsa Bernard Chris Abbosh Fabrice André Johan Auwerx Allan Balmain[...] Eileen White Frank Winkler John N WoodKaren Vousden Douglas Hanahan Cell Published 28 March 2024 Crick labsKaren VousdenCharles SwantonIlaria MalanchiGerard EvanFull details
Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details
Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth Authors (7)Anna Perdrix Rosell Oscar Maiques Joshua Alexander James Martin Probir ChakravartyLuigi Ombrato Victoria Sanz-MorenoIlaria Malanchi Cancer Letters Published 28 September 2022 Crick labs/ facilitiesIlaria MalanchiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
GREM1 is required to maintain cellular heterogeneity in pancreatic cancer Authors (21) Linxiang Lan Theodore Evan Huafu Li Aasia Hussain E Josue Ruiz May Zaw Thin[...]Emma Nye Yulong He Changhua Zhang Anguraj SadanandamAxel Behrens Nature Published 7 July 2022 Crick labs/ facilitiesIlaria MalanchiGeorge KassiotisAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick Rabas Celine Angeli Natascha Sewnath[...]Felipe Rodrigues Stuart HorswellPeter Faull Rebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Integrated OMICs unveil the bone-marrow microenvironment in human leukemia Authors (13)Diana PassaroManuel Garcia Albornoz Giovanni Diana Probir ChakravartyLinda Ariza-McnaughtonAntoniana Batsivari[...]Alexander WaclawiczekLuigi OmbratoIlaria Malanchi John GribbenDominique Bonnet Cell Reports Published 11 May 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetBioinformatics and BiostatisticsProteomicsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Metastatic-niche labelling reveals parenchymal cells with stem features Authors (18)Luigi OmbratoEmma Nolan Ivana Kurelac Antranik MavousianVicky Bridgeman Ivonne Heinze[...] Valerie SpeirsLucy Collinson Alessandro Ori Joo-Hyeon LeeIlaria Malanchi Nature Published 28 August 2019 Crick labs/ facilitiesIlaria MalanchiElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours Authors (19) Leander Blaas Fabio PucciHendrik Messal Agneta B Andersson E Josue Ruiz Marco Gerling[...] Jos Jonkers Gordon StampIlaria Malanchi Rune ToftgårdAxel Behrens Nature Cell Biology Published 1 December 2016 Crick labs/ facilitiesIlaria MalanchiAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
Integrin signalling regulates YAP and TAZ to control skin homeostasis Authors (16)Ahmed Elbediwy ZI Vincent-Mistiaen B Spencer-DeneRichard StoneStefan Boeing SK Wculek[...] H GerhardtAxel BehrensIlaria Malanchi OJ Sansom BJ Thompson Development Published 15 May 2016 Crick labs/ facilitiesBarry ThompsonErik SahaiIlaria MalanchiAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsFull details
Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization Authors (11) Yaiza del Pozo MartinDanielle ParkAnassuya RamachandranLuigi Ombrato Fernando Calvo Probir Chakravarty Bradley Spencer-Dene Stefanie DerzsiCaroline HillErik SahaiIlaria Malanchi Cell Reports Published 22 December 2015 Crick labs/ facilitiesErik SahaiIlaria MalanchiCaroline HillExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details