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Breadcrumb James Briscoe Briscoe lab Developmental Dynamics Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Collage of data and images examining the genes and mechanisms involved in spinal cord cell development. Toggle to view hero caption PublicationsYear published2024 (1)2023 (4)2022 (8)2021 (7)2020 (5)2019 (3)2018 (7)2017 (3)2016 (6)2015 (3)2014 (5)2013 (8)2012 (4)2011 (6)2010 (6) Facet Year publishedResearch topicsGene Expression (47)Computational & Systems Biology (46)Developmental Biology (46)Model Organisms (46)Neurosciences (46)Signalling & Oncogenes (46)Synthetic Biology (46)Genetics & Genomics (11)Tumour Biology (11)Chemical Biology & High Throughput (8)Immunology (8)Genome Integrity & Repair (7)Human Biology & Physiology (7)Cell Biology (4)Infectious Disease (4)Stem Cells (3)Biochemistry & Proteomics (2)Imaging (2)Cell Cycle & Chromosomes (1)Metabolism (1)Microfabrication & Bioengineering (1) Facet Research topicsPublication typeJournal article (76) (-)Primary research (76) Facet Publication typeJournalDevelopment (13)PLOS Biology (9)Developmental Cell (7)Nature Communications (4)Cell systems (3)eLife (3)Science (3)Cell (2)Nature Cell Biology (2)Nature Immunology (2)PLoS Computational Biology (2)PLOS Genetics (2)PLOS ONE (2)Proceedings of the National Academy of Sciences of USA (2)Cancer Research (1)Cell Death and Differentiation (1)Cell Stem Cell (1)Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society (1)Current Biology (1)Disease Models & Mechanisms (1)Genes & Development (1)Human Molecular Genetics (1)Journal of the Royal Society Interface (1)Metabolic Engineering (1)Methods in Molecular Biology (1)Nature (1)Nature Biotechnology (1)Nature Neuroscience (1)Nucleic Acids Research (1)Physical Review Research (1)Proceedings of the National Academy of Sciences of the United States of America (1)Science Signaling (1)Stem Cells (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 20 of 76Last updated : 24 April 2024 03:54 Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis Authors (16)Marisol Alvarez MartinezLuke CoxClaire F PearsonWilliam BranchettProbir ChakravartyXuemei Wu[...]Alejandro Suárez-BonnetAnna MikolajczakJames BriscoeFiona PowrieAnne O'Garra Nature Immunology Published 12 April 2024 Crick labs/ facilitiesAnne O’GarraJames BriscoeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryBiological Research FacilityAdvanced SequencingFull details Blimp-1 and c-Maf regulate Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells Authors (8)Luke CoxMarisol Alvarez MartinezXuemei WuLeona Gabrysova Raphaëlle LuisierJames BriscoeNicholas LuscombeAnne O'Garra Wellcome Open Research Published 1 December 2023 Crick labs/ facilitiesAnne O’GarraNicholas LuscombeJames BriscoeFlow CytometryBiological Research FacilityAdvanced SequencingFull details Optimal control of gene regulatory networks for morphogen-driven tissue patterning Authors (2) Alberto PezzottaJames Briscoe Cell systems Published 15 November 2023 Crick labsJames BriscoeFull details scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border Authors (7) Alexandre P Thiery Ailin Leticia Buzzi Eva HamrudChris CheshireNicholas LuscombeJames Briscoe Andrea Streit eLife Published 2 August 2023 Crick labs/ facilitiesNicholas LuscombeJames BriscoeAdvanced SequencingFull details Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production Authors (5) Moritz BenischDirk Benzinger Sant Kumar Hanrong Hu Mustafa Khammash Metabolic Engineering Published 1 May 2023 Crick labsJames BriscoeFull details Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies Authors (10)Joaquina Delas Vives Christos M Kalaitzis Tamara FawziMaddy DemuthIsabel ZhangHannah Stuart Elena CostantiniKenzo Ivanovitch Elly M TanakaJames Briscoe Developmental Cell Published 9 January 2023 Crick labs/ facilitiesJames BriscoeStructural BiologyScientific computingLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details 3D ECM-rich environment sustains the identity of naive human iPSCs Authors (19) Elisa Cesare Anna UrciuoloHannah Stuart Erika Torchio Alessia Gesualdo Cecilia Laterza[...] Riccardo M Betto Graziano Martello Davide Cacchiarelli Camilla Luni Nicola Elvassore Cell Stem Cell Published 1 December 2022 Crick labsJames BriscoeFull details ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex Authors (7) Claudia I Semprich Lindsay Davidson Adriana Amorim Torres Harshil PatelJames BriscoeVicki Metzis Kate G Storey PLOS Biology Published 1 December 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFull details Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension Authors (10) Min BaoJake Cornwall Scoones Estefania Sanchez-Vasquez Dong-Yuan ChenJoachim De Jonghe Shahriar Shadkhoo Florian Hollfelder Matt Thomson David M Glover Magdalena Zernicka-Goetz Nature Cell Biology Published 1 September 2022 Crick labsJames BriscoeFull details DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Sox8 remodels the cranial ectoderm to generate the ear Authors (5) Ailin Leticia Buzzi Jingchen Chen Alexandre ThieryJulien Delile Andrea Streit Proceedings of the National Academy of Sciences of USA Published 12 July 2022 Crick labsJames BriscoeFull details Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation Authors (7)Robert Blassberg Harshil Patel Thomas Watson Mina GoutiVicki MetzisJoaquina Delas VivesJames Briscoe Nature Cell Biology Published 1 May 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details Cell-intrinsic aryl hydrocarbon receptor signalling is required for the resolution of injury-induced colonic stem cells Authors (15)Kathleen ShahMuralidhara Maradana M Joaquina Delàs Amina Metidji Frederike GraelmannMiriam Llorian Sopena[...]Gavin KellyChris Cheshire Deendyal Bhurta Sandip B BharateBrigitta Stockinger Nature Communications Published 5 April 2022 Crick labs/ facilitiesGitta StockingerNicholas LuscombeJames BriscoeBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Free recall scaling laws and short-term memory effects in a latching attractor network Authors (3) Vezha Boboeva Alberto Pezzotta Claudia Clopath Proceedings of the National Academy of Sciences of USA Published 7 December 2021 Crick labsJames BriscoeFull details A shared transcriptional code orchestrates temporal patterning of the central nervous system Authors (6)Andreas SagnerIsabel Zhang Thomas Watson Jorge LazaroManuela MelchiondaJames Briscoe PLOS Biology Published 12 November 2021 Crick labs/ facilitiesJames BriscoeLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions Authors (6)Meritxell Saez CornellanaRobert Blassberg Elena Camacho-Aguilar Eric D Siggia David A RandJames Briscoe Cell systems Published 19 January 2022 Crick labs/ facilitiesJames BriscoeScientific computingFlow CytometryFull details Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis Authors (20) T Lohoff S Ghazanfar A Missarova N Koulena N Pierson JA Griffiths[...] B Göttgens W Reik J Nichols L Cai JC Marioni Nature Biotechnology Published 1 January 2022 Crick labsJames BriscoeFull details Single cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human specific features Authors (4)Teresa Rayon AlonsoRory Maizels Christopher BarringtonJames Briscoe Development Published 16 July 2021 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsScientific computingExperimental HistopathologyAdvanced SequencingFull details Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak Authors (10)Kenzo Ivanovitch Pablo Soro-Barrio Probir ChakravartyRebecca JonesDonald Bell S Neda Mousavy GharavyDespina StamatakiJulien DelileJim SmithJames Briscoe PLOS Biology Published 17 May 2021 Crick labs/ facilitiesJim SmithJames BriscoeLight MicroscopyBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks Authors (8)Katherine ExelbyEdgar Herrera Delgado Lorena Garcia Perez Ruben Perez-CarrascoAndreas SagnerVicki Metzis Peter SollichJames Briscoe Development Published 25 February 2021 Crick labs/ facilitiesJames BriscoeScientific computingFlow CytometryBiological Research FacilityFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis Authors (16)Marisol Alvarez MartinezLuke CoxClaire F PearsonWilliam BranchettProbir ChakravartyXuemei Wu[...]Alejandro Suárez-BonnetAnna MikolajczakJames BriscoeFiona PowrieAnne O'Garra Nature Immunology Published 12 April 2024 Crick labs/ facilitiesAnne O’GarraJames BriscoeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Blimp-1 and c-Maf regulate Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells Authors (8)Luke CoxMarisol Alvarez MartinezXuemei WuLeona Gabrysova Raphaëlle LuisierJames BriscoeNicholas LuscombeAnne O'Garra Wellcome Open Research Published 1 December 2023 Crick labs/ facilitiesAnne O’GarraNicholas LuscombeJames BriscoeFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Optimal control of gene regulatory networks for morphogen-driven tissue patterning Authors (2) Alberto PezzottaJames Briscoe Cell systems Published 15 November 2023 Crick labsJames BriscoeFull details
scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border Authors (7) Alexandre P Thiery Ailin Leticia Buzzi Eva HamrudChris CheshireNicholas LuscombeJames Briscoe Andrea Streit eLife Published 2 August 2023 Crick labs/ facilitiesNicholas LuscombeJames BriscoeAdvanced SequencingFull details
Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production Authors (5) Moritz BenischDirk Benzinger Sant Kumar Hanrong Hu Mustafa Khammash Metabolic Engineering Published 1 May 2023 Crick labsJames BriscoeFull details
Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies Authors (10)Joaquina Delas Vives Christos M Kalaitzis Tamara FawziMaddy DemuthIsabel ZhangHannah Stuart Elena CostantiniKenzo Ivanovitch Elly M TanakaJames Briscoe Developmental Cell Published 9 January 2023 Crick labs/ facilitiesJames BriscoeStructural BiologyScientific computingLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
3D ECM-rich environment sustains the identity of naive human iPSCs Authors (19) Elisa Cesare Anna UrciuoloHannah Stuart Erika Torchio Alessia Gesualdo Cecilia Laterza[...] Riccardo M Betto Graziano Martello Davide Cacchiarelli Camilla Luni Nicola Elvassore Cell Stem Cell Published 1 December 2022 Crick labsJames BriscoeFull details
ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex Authors (7) Claudia I Semprich Lindsay Davidson Adriana Amorim Torres Harshil PatelJames BriscoeVicki Metzis Kate G Storey PLOS Biology Published 1 December 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFull details
Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension Authors (10) Min BaoJake Cornwall Scoones Estefania Sanchez-Vasquez Dong-Yuan ChenJoachim De Jonghe Shahriar Shadkhoo Florian Hollfelder Matt Thomson David M Glover Magdalena Zernicka-Goetz Nature Cell Biology Published 1 September 2022 Crick labsJames BriscoeFull details
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Sox8 remodels the cranial ectoderm to generate the ear Authors (5) Ailin Leticia Buzzi Jingchen Chen Alexandre ThieryJulien Delile Andrea Streit Proceedings of the National Academy of Sciences of USA Published 12 July 2022 Crick labsJames BriscoeFull details
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation Authors (7)Robert Blassberg Harshil Patel Thomas Watson Mina GoutiVicki MetzisJoaquina Delas VivesJames Briscoe Nature Cell Biology Published 1 May 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details
Cell-intrinsic aryl hydrocarbon receptor signalling is required for the resolution of injury-induced colonic stem cells Authors (15)Kathleen ShahMuralidhara Maradana M Joaquina Delàs Amina Metidji Frederike GraelmannMiriam Llorian Sopena[...]Gavin KellyChris Cheshire Deendyal Bhurta Sandip B BharateBrigitta Stockinger Nature Communications Published 5 April 2022 Crick labs/ facilitiesGitta StockingerNicholas LuscombeJames BriscoeBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Free recall scaling laws and short-term memory effects in a latching attractor network Authors (3) Vezha Boboeva Alberto Pezzotta Claudia Clopath Proceedings of the National Academy of Sciences of USA Published 7 December 2021 Crick labsJames BriscoeFull details
A shared transcriptional code orchestrates temporal patterning of the central nervous system Authors (6)Andreas SagnerIsabel Zhang Thomas Watson Jorge LazaroManuela MelchiondaJames Briscoe PLOS Biology Published 12 November 2021 Crick labs/ facilitiesJames BriscoeLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions Authors (6)Meritxell Saez CornellanaRobert Blassberg Elena Camacho-Aguilar Eric D Siggia David A RandJames Briscoe Cell systems Published 19 January 2022 Crick labs/ facilitiesJames BriscoeScientific computingFlow CytometryFull details
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis Authors (20) T Lohoff S Ghazanfar A Missarova N Koulena N Pierson JA Griffiths[...] B Göttgens W Reik J Nichols L Cai JC Marioni Nature Biotechnology Published 1 January 2022 Crick labsJames BriscoeFull details
Single cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human specific features Authors (4)Teresa Rayon AlonsoRory Maizels Christopher BarringtonJames Briscoe Development Published 16 July 2021 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsScientific computingExperimental HistopathologyAdvanced SequencingFull details
Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak Authors (10)Kenzo Ivanovitch Pablo Soro-Barrio Probir ChakravartyRebecca JonesDonald Bell S Neda Mousavy GharavyDespina StamatakiJulien DelileJim SmithJames Briscoe PLOS Biology Published 17 May 2021 Crick labs/ facilitiesJim SmithJames BriscoeLight MicroscopyBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details
Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks Authors (8)Katherine ExelbyEdgar Herrera Delgado Lorena Garcia Perez Ruben Perez-CarrascoAndreas SagnerVicki Metzis Peter SollichJames Briscoe Development Published 25 February 2021 Crick labs/ facilitiesJames BriscoeScientific computingFlow CytometryBiological Research FacilityFull details