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Breadcrumb James Briscoe Briscoe lab Developmental Dynamics Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Collage of data and images examining the genes and mechanisms involved in spinal cord cell development. Toggle to view hero caption PublicationsYear published2024 (1)2023 (1)2022 (1)2020 (1)2019 (1)2018 (1)2015 (1) Facet Year publishedResearch topicsGene Expression (7)Immunology (7)Computational & Systems Biology (6)Developmental Biology (6)Model Organisms (6)Neurosciences (6)Signalling & Oncogenes (6)Synthetic Biology (6)Tumour Biology (5)Genetics & Genomics (4)Infectious Disease (4)Cell Biology (3)Chemical Biology & High Throughput (3)Genome Integrity & Repair (2)Biochemistry & Proteomics (1)Imaging (1)Metabolism (1)Microfabrication & Bioengineering (1)Stem Cells (1) (-)Human Biology & Physiology (7) Facet Research topicsPublication typeJournal article (7)Primary research (7) Facet Publication typeJournalNature Immunology (2)Developmental Cell (1)Human Molecular Genetics (1)Nature Communications (1)Science (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 7 of 7Last updated : 25 April 2024 02:04 Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis Authors (16)Marisol Alvarez MartinezLuke CoxClaire F PearsonWilliam BranchettProbir ChakravartyXuemei Wu[...]Alejandro Suárez-BonnetAnna MikolajczakJames BriscoeFiona PowrieAnne O'Garra Nature Immunology Published 12 April 2024 Crick labs/ facilitiesAnne O’GarraJames BriscoeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryBiological Research FacilityAdvanced SequencingFull details Blimp-1 and c-Maf regulate Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells Authors (8)Luke CoxMarisol Alvarez MartinezXuemei WuLeona Gabrysova Raphaëlle LuisierJames BriscoeNicholas LuscombeAnne O'Garra Wellcome Open Research Published 1 December 2023 Crick labs/ facilitiesAnne O’GarraNicholas LuscombeJames BriscoeFlow CytometryBiological Research FacilityAdvanced SequencingFull details DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Species-specific pace of development is associated with differences in protein stability Authors (11)Teresa Rayon AlonsoDespina Stamataki Ruben Perez-CarrascoLorena Garcia-Perez Christopher BarringtonManuela MelchiondaKatherine Exelby Jorge LazaroVictor Tybulewicz Elizabeth MC FisherJames Briscoe Science Published 18 September 2020 Crick labs/ facilitiesVictor TybulewiczJames BriscoeBioinformatics and BiostatisticsFull details Gene expression dysregulation domains are not a specific feature of Down syndrome Authors (12) Helena Ahlfors Nnneka Anyanwu Edvinas Pakanavicius Natalia DinischiotuEva Lana-Elola Sheona Watson-Scales[...] Frances WisemanJames Briscoe Karen Page Elizabeth MC FisherVictor Tybulewicz Nature Communications Published 6 June 2019 Crick labs/ facilitiesVictor TybulewiczJames BriscoeGenetic Modification ServiceBiological Research FacilityAdvanced SequencingFull details c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells Authors (21)Leona GabrysovaMarisol Alvarez Martinez Raphaëlle LuisierLuke Cox Jan SodenkampCaroline Hosking[...]James BriscoeVicki Metzis Jean LanghorneNicholas LuscombeAnne O'Garra Nature Immunology Published 1 May 2018 Crick labs/ facilitiesAnne O’GarraNicholas LuscombeJean LanghorneJames BriscoeAdvanced SequencingFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz Syndrome Authors (4)Robert BlassbergJames MacraeJames Briscoe John Jacob Human Molecular Genetics Published 15 February 2016 Crick labs/ facilitiesJames BriscoeMetabolomicsFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis Authors (16)Marisol Alvarez MartinezLuke CoxClaire F PearsonWilliam BranchettProbir ChakravartyXuemei Wu[...]Alejandro Suárez-BonnetAnna MikolajczakJames BriscoeFiona PowrieAnne O'Garra Nature Immunology Published 12 April 2024 Crick labs/ facilitiesAnne O’GarraJames BriscoeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Blimp-1 and c-Maf regulate Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells Authors (8)Luke CoxMarisol Alvarez MartinezXuemei WuLeona Gabrysova Raphaëlle LuisierJames BriscoeNicholas LuscombeAnne O'Garra Wellcome Open Research Published 1 December 2023 Crick labs/ facilitiesAnne O’GarraNicholas LuscombeJames BriscoeFlow CytometryBiological Research FacilityAdvanced SequencingFull details
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Species-specific pace of development is associated with differences in protein stability Authors (11)Teresa Rayon AlonsoDespina Stamataki Ruben Perez-CarrascoLorena Garcia-Perez Christopher BarringtonManuela MelchiondaKatherine Exelby Jorge LazaroVictor Tybulewicz Elizabeth MC FisherJames Briscoe Science Published 18 September 2020 Crick labs/ facilitiesVictor TybulewiczJames BriscoeBioinformatics and BiostatisticsFull details
Gene expression dysregulation domains are not a specific feature of Down syndrome Authors (12) Helena Ahlfors Nnneka Anyanwu Edvinas Pakanavicius Natalia DinischiotuEva Lana-Elola Sheona Watson-Scales[...] Frances WisemanJames Briscoe Karen Page Elizabeth MC FisherVictor Tybulewicz Nature Communications Published 6 June 2019 Crick labs/ facilitiesVictor TybulewiczJames BriscoeGenetic Modification ServiceBiological Research FacilityAdvanced SequencingFull details
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells Authors (21)Leona GabrysovaMarisol Alvarez Martinez Raphaëlle LuisierLuke Cox Jan SodenkampCaroline Hosking[...]James BriscoeVicki Metzis Jean LanghorneNicholas LuscombeAnne O'Garra Nature Immunology Published 1 May 2018 Crick labs/ facilitiesAnne O’GarraNicholas LuscombeJean LanghorneJames BriscoeAdvanced SequencingFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz Syndrome Authors (4)Robert BlassbergJames MacraeJames Briscoe John Jacob Human Molecular Genetics Published 15 February 2016 Crick labs/ facilitiesJames BriscoeMetabolomicsFull details