Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb James Briscoe Briscoe lab Developmental Dynamics Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Collage of data and images examining the genes and mechanisms involved in spinal cord cell development. Toggle to view hero caption PublicationsYear published (-)2022 (13) Facet Year publishedResearch topicsComputational & Systems Biology (13)Developmental Biology (13)Gene Expression (13)Model Organisms (13)Neurosciences (13)Signalling & Oncogenes (13)Synthetic Biology (13)Chemical Biology & High Throughput (3)Genetics & Genomics (3)Genome Integrity & Repair (3)Tumour Biology (3)Immunology (2)Human Biology & Physiology (1)Imaging (1)Infectious Disease (1)Microfabrication & Bioengineering (1)Stem Cells (1) Facet Research topicsPublication typeJournal article (13)Primary research (8)Editorial (3)Review (2) Facet Publication typeJournalDevelopment (4)Developmental Cell (2)Nature Cell Biology (2)Cell Stem Cell (1)Interface focus (1)Nature Communications (1)PLOS Biology (1)Proceedings of the National Academy of Sciences of USA (1) Facet Journal Publications Displaying 1 - 13 of 13Last updated : 20 April 2024 03:28 Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies Authors (10)Joaquina Delas Vives Christos M Kalaitzis Tamara FawziMaddy DemuthIsabel ZhangHannah Stuart Elena CostantiniKenzo Ivanovitch Elly M TanakaJames Briscoe Developmental Cell Published 9 January 2023 Crick labs/ facilitiesJames BriscoeStructural BiologyScientific computingLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details The Pathway to Independence programme: helping postdocs navigate the transition to independence Authors (2)James Briscoe Katherine Brown Development Published 1 December 2022 Crick labsJames BriscoeFull details 3D ECM-rich environment sustains the identity of naive human iPSCs Authors (19) Elisa Cesare Anna UrciuoloHannah Stuart Erika Torchio Alessia Gesualdo Cecilia Laterza[...] Riccardo M Betto Graziano Martello Davide Cacchiarelli Camilla Luni Nicola Elvassore Cell Stem Cell Published 1 December 2022 Crick labsJames BriscoeFull details ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex Authors (7) Claudia I Semprich Lindsay Davidson Adriana Amorim Torres Harshil PatelJames BriscoeVicki Metzis Kate G Storey PLOS Biology Published 1 December 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFull details Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension Authors (10) Min Bao Jake Cornwall-Scoones Estefania Sanchez-Vasquez Dong-Yuan ChenJoachim De Jonghe Shahriar Shadkhoo Florian Hollfelder Matt Thomson David M Glover Magdalena Zernicka-Goetz Nature Cell Biology Published 1 September 2022 Crick labsJames BriscoeFull details DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details In preprints: morphogens in motion Authors (2) Kristina S StapornwongkulJames Briscoe Development Published 15 July 2022 Crick labsJames BriscoeFull details Sox8 remodels the cranial ectoderm to generate the ear Authors (5) Ailin Leticia Buzzi Jingchen Chen Alexandre ThieryJulien Delile Andrea Streit Proceedings of the National Academy of Sciences of USA Published 12 July 2022 Crick labsJames BriscoeFull details Dynamical landscapes of cell fate decisions Authors (3)Meritxell Saez CornellanaJames Briscoe DA Rand Interface focus Published 6 August 2022 Crick labsJames BriscoeFull details Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation Authors (7)Robert Blassberg Harshil Patel Thomas Watson Mina GoutiVicki MetzisJoaquina Delas VivesJames Briscoe Nature Cell Biology Published 1 May 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details Cell-intrinsic aryl hydrocarbon receptor signalling is required for the resolution of injury-induced colonic stem cells Authors (15)Kathleen ShahMuralidhara Maradana M Joaquina Delàs Amina Metidji Frederike GraelmannMiriam Llorian Sopena[...]Gavin KellyChris Cheshire Deendyal Bhurta Sandip B BharateBrigitta Stockinger Nature Communications Published 5 April 2022 Crick labs/ facilitiesGitta StockingerNicholas LuscombeJames BriscoeBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Preprints in Development Authors (2)James Briscoe Seema Grewal Development Published 1 April 2022 Crick labsJames BriscoeFull details Another year of Developments Authors (2)James Briscoe Seema Grewal Development Published 1 January 2022 Crick labsJames BriscoeFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies Authors (10)Joaquina Delas Vives Christos M Kalaitzis Tamara FawziMaddy DemuthIsabel ZhangHannah Stuart Elena CostantiniKenzo Ivanovitch Elly M TanakaJames Briscoe Developmental Cell Published 9 January 2023 Crick labs/ facilitiesJames BriscoeStructural BiologyScientific computingLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
The Pathway to Independence programme: helping postdocs navigate the transition to independence Authors (2)James Briscoe Katherine Brown Development Published 1 December 2022 Crick labsJames BriscoeFull details
3D ECM-rich environment sustains the identity of naive human iPSCs Authors (19) Elisa Cesare Anna UrciuoloHannah Stuart Erika Torchio Alessia Gesualdo Cecilia Laterza[...] Riccardo M Betto Graziano Martello Davide Cacchiarelli Camilla Luni Nicola Elvassore Cell Stem Cell Published 1 December 2022 Crick labsJames BriscoeFull details
ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex Authors (7) Claudia I Semprich Lindsay Davidson Adriana Amorim Torres Harshil PatelJames BriscoeVicki Metzis Kate G Storey PLOS Biology Published 1 December 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFull details
Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension Authors (10) Min Bao Jake Cornwall-Scoones Estefania Sanchez-Vasquez Dong-Yuan ChenJoachim De Jonghe Shahriar Shadkhoo Florian Hollfelder Matt Thomson David M Glover Magdalena Zernicka-Goetz Nature Cell Biology Published 1 September 2022 Crick labsJames BriscoeFull details
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
In preprints: morphogens in motion Authors (2) Kristina S StapornwongkulJames Briscoe Development Published 15 July 2022 Crick labsJames BriscoeFull details
Sox8 remodels the cranial ectoderm to generate the ear Authors (5) Ailin Leticia Buzzi Jingchen Chen Alexandre ThieryJulien Delile Andrea Streit Proceedings of the National Academy of Sciences of USA Published 12 July 2022 Crick labsJames BriscoeFull details
Dynamical landscapes of cell fate decisions Authors (3)Meritxell Saez CornellanaJames Briscoe DA Rand Interface focus Published 6 August 2022 Crick labsJames BriscoeFull details
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation Authors (7)Robert Blassberg Harshil Patel Thomas Watson Mina GoutiVicki MetzisJoaquina Delas VivesJames Briscoe Nature Cell Biology Published 1 May 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details
Cell-intrinsic aryl hydrocarbon receptor signalling is required for the resolution of injury-induced colonic stem cells Authors (15)Kathleen ShahMuralidhara Maradana M Joaquina Delàs Amina Metidji Frederike GraelmannMiriam Llorian Sopena[...]Gavin KellyChris Cheshire Deendyal Bhurta Sandip B BharateBrigitta Stockinger Nature Communications Published 5 April 2022 Crick labs/ facilitiesGitta StockingerNicholas LuscombeJames BriscoeBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Preprints in Development Authors (2)James Briscoe Seema Grewal Development Published 1 April 2022 Crick labsJames BriscoeFull details
Another year of Developments Authors (2)James Briscoe Seema Grewal Development Published 1 January 2022 Crick labsJames BriscoeFull details