Publications

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

Authors (9)

Giovanni Luchetti
Ria Sircar
Jennifer H Kong
Sigrid Nachtergaele
Andreas Sagner
Eamon FX Byrne
Douglas F Covey
Christian Siebold
Rajat Rohatgi

eLife

Published 5 October 2016

Crick labs

James Briscoe

Full details

Directing the spatial patterning of motor neuron differentiation in engineered microenvironments

Authors (4)

Christopher J Demers
Greg Cox
Scott D Collins
Rosemary L Smith

Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Published 1 August 2016

Crick labs

James Briscoe

Full details

Development-on-chip: in vitro neural tube patterning with a microfluidic device

Authors (7)

Christopher Demers
Prabakaran Soundararajan
Phaneendra Chennampally
Gregory A Cox
James Briscoe
Scott D Collins
Rosemary L Smith

Development

Published 1 June 2016

Crick labs

James Briscoe

Full details

Mathematical models help explain experimental data. Response to 'Transcriptional interpretation of Shh morphogen signaling: computational modeling validates empirically established models'

Authors (5)

Michael Cohen
Karen M Page
Ruben Perez-Carrasco
Chris P Barnes
James Briscoe

Development

Published 15 May 2016

Crick labs

James Briscoe

Full details

Scaling pattern to variations in size during development of the vertebrate neural tube

Authors (6)

Aysu Uygur
John Young
Tyler R Huycke
Mervenaz Koska
James Briscoe
Clifford J Tabin

Developmental Cell

Published 18 April 2016

Crick labs

James Briscoe

Full details

Neural progenitors adopt specific identities by directly repressing all alternative progenitor transcriptional programs

Authors (5)

Eva Kutejova
Noriaki Sasai
Ankita Shah
Mina Gouti
James Briscoe

Developmental Cell

Published 21 March 2016

Crick labs/ facilities

Full details

Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz Syndrome

Authors (4)

Human Molecular Genetics

Published 15 February 2016

Crick labs/ facilities

Full details

Morphogen rules: design principles of gradient-mediated embryo patterning

Authors (2)

James Briscoe
Stephen Small

Development

Published 1 December 2015

Crick labs

James Briscoe

Full details

Developmental pattern formation in phases

Authors (2)

Anna Kicheva
James Briscoe

Trends in Cell Biology

Published 1 October 2015

Crick labs

James Briscoe

Full details

Notch activity modulates the responsiveness of neural progenitors to Sonic hedgehog signaling

Authors (8)

Jennifer H Kong
Linlin Yang
Eric Dessaud
Katherine Chuang
Destaye M Moore
Rajat Rohatgi
James Briscoe
Bennett G Novitch

Developmental Cell

Published 26 May 2015

Crick labs

James Briscoe

Full details

Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms

Authors (7)

Michael Cohen
Anna Kicheva
Ana Ribeiro
Robert Blassberg
Karen M Page
Chris P Barnes
James Briscoe

Nature Communications

Published 2 April 2015

Crick labs

James Briscoe

Full details

The route to spinal cord cell types: a tale of signals and switches

Authors (3)

Trends in Genetics

Published 27 March 2015

Crick labs

James Briscoe

Full details

Morphogens, modeling and patterning the neural tube: an interview with James Briscoe

Authors (1)

James Briscoe

BMC Biology

Published 1 January 2015

Crick labs

James Briscoe

Full details

A theoretical framework for the regulation of Shh morphogen-controlled gene expression

Authors (5)

Michael Cohen
Karen M Page
Ruben Perez-Carrasco
Chris P Barnes
James Briscoe

Development

Published 1 October 2014

Crick labs

James Briscoe

Full details

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis

Authors (22)

Paraskevi Goggolidou
Jonathan L Stevens
Francesco Agueci
Jennifer Keynton
Gabrielle Wheway
Daniel T Grimes
[...]
Grigory L Dianov
James Briscoe
Colin A Johnson
Lotte B Pedersen
Dominic P Norris

Development

Published 1 October 2014

Crick labs

James Briscoe

Full details

Coordination of progenitor specification and growth in mouse and chick spinal cord

Authors (7)

Anna Kicheva
Tobias Bollenbach
Ana Ribeiro
Helena Pérez Valle
Robin Lovell-Badge
Vasso Episkopou
James Briscoe

Science

Published 26 September 2014

Crick labs

Full details

In vitro generation of neuromesodermal progenitors reveals distinct roles for Wnt signalling in the specification of spinal cord and paraxial mesoderm identity

Authors (7)

Mina Gouti
Anestis Tsakiridis
Filip J Wymeersch
Yali Huang
Jens Kleinjung
Valerie Wilson
James Briscoe

PLOS Biology

Published 1 August 2014

Crick labs

Full details

Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity

Authors (3)

Noriaki Sasai
Eva Kutejova
James Briscoe

PLOS Biology

Published 1 July 2014

Crick labs

James Briscoe

Full details

Hedgehog threads to spread

Authors (2)

Nature Cell Biology

Published 5 November 2013

Crick labs

Full details

Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome

Authors (10)

J Jacob
V Ribes
S Moore
SC Constable
N Sasai
SS Gerety
DJ Martin
CP Sergeant
DG Wilkinson
James Briscoe

Disease Models & Mechanisms

Published 17 October 2013

Crick labs

Full details

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Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

Directing the spatial patterning of motor neuron differentiation in engineered microenvironments

Development-on-chip: in vitro neural tube patterning with a microfluidic device

Mathematical models help explain experimental data. Response to 'Transcriptional interpretation of Shh morphogen signaling: computational modeling validates empirically established models'

Scaling pattern to variations in size during development of the vertebrate neural tube

Neural progenitors adopt specific identities by directly repressing all alternative progenitor transcriptional programs

Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz Syndrome

Morphogen rules: design principles of gradient-mediated embryo patterning

Developmental pattern formation in phases

Notch activity modulates the responsiveness of neural progenitors to Sonic hedgehog signaling

Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms

The route to spinal cord cell types: a tale of signals and switches

Morphogens, modeling and patterning the neural tube: an interview with James Briscoe

A theoretical framework for the regulation of Shh morphogen-controlled gene expression

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis

Coordination of progenitor specification and growth in mouse and chick spinal cord

In vitro generation of neuromesodermal progenitors reveals distinct roles for Wnt signalling in the specification of spinal cord and paraxial mesoderm identity

Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity

Hedgehog threads to spread

Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome

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