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Breadcrumb James Turner Turner lab Sex Chromosome Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Meet us PublicationsYear published2023 (1)2022 (2)2021 (6)2020 (8)2019 (1)2018 (4)2017 (5)2016 (2)2015 (5)2013 (2)2012 (5)2011 (3)2010 (2) Facet Year publishedResearch topicsCell Biology (33)Cell Cycle & Chromosomes (33)Genetics & Genomics (33)Genome Integrity & Repair (33)Human Biology & Physiology (33)Stem Cells (33)Developmental Biology (32)Gene Expression (32)Model Organisms (32)Chemical Biology & High Throughput (5)Tumour Biology (5)Computational & Systems Biology (4)Signalling & Oncogenes (4)Neurosciences (3)Biochemistry & Proteomics (2)Imaging (2)Infectious Disease (2)Metabolism (2)Structural Biology & Biophysics (2)Immunology (1)Microfabrication & Bioengineering (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (46)Primary research (33)Review (9)Method (2)Letter (1)Obituary (1) Facet Publication typeJournalPLOS Genetics (5)Development (4)Nature (4)Nature Communications (4)Current Biology (3)Developmental Cell (2)eLife (2)Genes & Development (2)Annual Review of Cell and Developmental Biology (1)Annual Review of Genetics (1)BioEssays (1)Cell (1)Cell Reports Methods (1)Chromosoma (1)Cold Spring Harbor Perspectives in Biology (1)Current Protocols (1)Human Molecular Genetics (1)Journal of Biological Chemistry (1)Molecular Biology of the Cell (1)Nature Biotechnology (1)Nucleic Acids Research (1)Philosophical Transactions of the Royal Society of London: Biological Sciences (1)PLOS ONE (1)Proceedings of the National Academy of Sciences of the United States of America (1)Proceedings of the National Academy of Sciences of USA (1)Psychoneuroendocrinology (1)Science (1)The Lancet (1) Facet Journal Publications Displaying 1 - 20 of 46Last updated : 02 December 2023 03:32 Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells Authors (18) Nicola Dark Marie-Victoire CossonLorenza Iolanda Tsansizi Thomas J Owen Elisa Ferraro Alice J Francis[...] Elisabeth Ehler Richard Mitter Sian E HardingJim Smith Andreia S Bernardo Cell Reports Methods Published 24 April 2023 Crick labs/ facilitiesJames TurnerJim SmithElectron MicroscopyBioinformatics and BiostatisticsFull details TAF4b transcription networks regulating early oocyte differentiation Authors (9) Megan A Gura Soňa Relovská Kimberly M Abt Kimberly A Seymour Tong WuHaskan KayaJames Turner Thomas G Fazzio Richard N Freiman Development Published 1 February 2022 Crick labsJames TurnerFull details Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis Authors (21) Catalina Pereira Gerardo A Arroyo-Martinez Matthew Z Guo Michael S Downey Emma R Kelly Kathryn J Grive[...] Amy M Lyndaker Miguel A Brieno-Enriquez Paula E Cohen Marcus B Smolka Robert S Weiss eLife Published 8 February 2022 Crick labsJames TurnerFull details CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes Authors (8)Charlotte DouglasValdone MaciulyteJasmin ZohrenDaniel SnellShantha MahadevaiahAndrew Ojarikre Peter JI EllisJames Turner Nature Communications Published 3 December 2021 Crick labs/ facilitiesJames TurnerLight MicroscopyIn Vivo ImagingGenetic Modification ServiceFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Y chromosome functions in mammalian spermatogenesis Authors (2)Jeremie SubriniJames Turner eLife Published 4 October 2021 Crick labsJames TurnerFull details Generating CRISPR-Cas9-mediated null mutations and screening targeting efficiency in human pluripotent stem cells Authors (8)Oliver BowerAfshan MccarthyRebecca LeaGregorio Alanis LobatoJasmin ZohrenClaudia GerriJames TurnerKathy Niakan Current Protocols Published 25 August 2021 Crick labs/ facilitiesJames TurnerKathy NiakanHuman Embryonic Stem CellAdvanced SequencingFull details Epigenetics drive the evolution of sex chromosomes in animals and plants Authors (4) Aline Muyle Doris Bachtrog Gabriel AB MaraisJames Turner Philosophical Transactions of the Royal Society of London: Biological Sciences Published 7 June 2021 Crick labsJames TurnerFull details Frequent loss-of-heterozygosity in CRISPR-Cas9–editedearly human embryos Authors (10)Gregorio Alanis LobatoJasmin ZohrenAfshan MccarthyNorah Fogarty Nada KubikovaEmily HardmanMaria Greco Dagan WellsJames TurnerKathy Niakan Proceedings of the National Academy of Sciences of USA Published 1 June 2021 Crick labs/ facilitiesJames TurnerKathy NiakanAdvanced SequencingAdvanced SequencingFull details Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice Authors (13) Ihsan Dereli Marcello Stanzione Fabrizio Olmeda Frantzeskos Papanikos Marek Baumann Sevgican Demir[...] Bernard de Massy Willy M BaarendsJames Turner Steffen Rulands Attila Tóth Nucleic Acids Research Published 18 March 2021 Crick labsJames TurnerFull details Paul S. Burgoyne (1946-2020) Authors (4)James TurnerShantha Mahadevaiah Arthur P ArnoldRobin Lovell-Badge Development Published 27 October 2020 Crick labsJames TurnerRobin Lovell-BadgeFull details Human embryogenesis: A comparative perspective Authors (5)Claudia GerriSergio Menchero FernandezShantha MahadevaiahJames TurnerKathy Niakan Annual Review of Cell and Developmental Biology Published 6 October 2020 Crick labsJames TurnerKathy NiakanFull details A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation Authors (4)Shantha Mahadevaiah Mahesh N SangrithiTakayuki HirotaJames Turner Nature Published 22 October 2020 Crick labs/ facilitiesJames TurnerLight MicroscopyBiological Research FacilityAdvanced SequencingFull details Advances and challenges in genetic technologies to produce single-sex litters Authors (2)Charlotte DouglasJames Turner PLOS Genetics Published 23 July 2020 Crick labsJames TurnerFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...] Sophia Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes Authors (12)Elias ElinatiAgata ZielinskaAfshan Mccarthy Nada KubikovaValdone MaciulyteShantha Mahadevaiah[...]Andrew Ojarikre Dagan WellsKathy Niakan Melina SchuhJames Turner Nature Communications Published 25 May 2020 Crick labs/ facilitiesJames TurnerKathy NiakanLight MicroscopyExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche Authors (17) Sissy E Wamaitha Katarzyna J GrybelGregorio Alanis LobatoClaudia GerriSugako OgushiAfshan Mccarthy[...] Phil Snell Leila ChristieJulian DownwardJames TurnerKathy Niakan Nature Communications Published 7 February 2020 Crick labs/ facilitiesJames TurnerKathy NiakanJulian DownwardHuman Embryonic Stem CellScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsFull details Gene expression across mammalian organ development Authors (33)Margarida Cardoso Moreira Jean Halbert Delphine Valloton Britta Velten Chunyan Chen Yi Shao[...] Wolfgang Huber Julie Baker Simon Anders Yong E Zhang Henrik Kaessmann Nature Published 1 July 2019 Crick labsJames TurnerMargarida Cardoso-MoreiraFull details Sex chromosome effects on male-female differences in mammals Authors (2)Daniel SnellJames Turner Current Biology Published 19 November 2018 Crick labsJames TurnerFull details SETDB1 links the meiotic DNA damage response to sex chromosome silencing in mice Authors (11)Takayuki Hirota Paul Blakeley Mahesh N SangrithiShantha Mahadevaiah Vesela EnchevaBram SnijdersElias Elinati Obah A Ojarikre Dirk G de RooijKathy NiakanJames Turner Developmental Cell Published 3 December 2018 Crick labs/ facilitiesJames TurnerKathy NiakanProteomicsLight MicroscopyExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells Authors (18) Nicola Dark Marie-Victoire CossonLorenza Iolanda Tsansizi Thomas J Owen Elisa Ferraro Alice J Francis[...] Elisabeth Ehler Richard Mitter Sian E HardingJim Smith Andreia S Bernardo Cell Reports Methods Published 24 April 2023 Crick labs/ facilitiesJames TurnerJim SmithElectron MicroscopyBioinformatics and BiostatisticsFull details
TAF4b transcription networks regulating early oocyte differentiation Authors (9) Megan A Gura Soňa Relovská Kimberly M Abt Kimberly A Seymour Tong WuHaskan KayaJames Turner Thomas G Fazzio Richard N Freiman Development Published 1 February 2022 Crick labsJames TurnerFull details
Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis Authors (21) Catalina Pereira Gerardo A Arroyo-Martinez Matthew Z Guo Michael S Downey Emma R Kelly Kathryn J Grive[...] Amy M Lyndaker Miguel A Brieno-Enriquez Paula E Cohen Marcus B Smolka Robert S Weiss eLife Published 8 February 2022 Crick labsJames TurnerFull details
CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes Authors (8)Charlotte DouglasValdone MaciulyteJasmin ZohrenDaniel SnellShantha MahadevaiahAndrew Ojarikre Peter JI EllisJames Turner Nature Communications Published 3 December 2021 Crick labs/ facilitiesJames TurnerLight MicroscopyIn Vivo ImagingGenetic Modification ServiceFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Y chromosome functions in mammalian spermatogenesis Authors (2)Jeremie SubriniJames Turner eLife Published 4 October 2021 Crick labsJames TurnerFull details
Generating CRISPR-Cas9-mediated null mutations and screening targeting efficiency in human pluripotent stem cells Authors (8)Oliver BowerAfshan MccarthyRebecca LeaGregorio Alanis LobatoJasmin ZohrenClaudia GerriJames TurnerKathy Niakan Current Protocols Published 25 August 2021 Crick labs/ facilitiesJames TurnerKathy NiakanHuman Embryonic Stem CellAdvanced SequencingFull details
Epigenetics drive the evolution of sex chromosomes in animals and plants Authors (4) Aline Muyle Doris Bachtrog Gabriel AB MaraisJames Turner Philosophical Transactions of the Royal Society of London: Biological Sciences Published 7 June 2021 Crick labsJames TurnerFull details
Frequent loss-of-heterozygosity in CRISPR-Cas9–editedearly human embryos Authors (10)Gregorio Alanis LobatoJasmin ZohrenAfshan MccarthyNorah Fogarty Nada KubikovaEmily HardmanMaria Greco Dagan WellsJames TurnerKathy Niakan Proceedings of the National Academy of Sciences of USA Published 1 June 2021 Crick labs/ facilitiesJames TurnerKathy NiakanAdvanced SequencingAdvanced SequencingFull details
Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice Authors (13) Ihsan Dereli Marcello Stanzione Fabrizio Olmeda Frantzeskos Papanikos Marek Baumann Sevgican Demir[...] Bernard de Massy Willy M BaarendsJames Turner Steffen Rulands Attila Tóth Nucleic Acids Research Published 18 March 2021 Crick labsJames TurnerFull details
Paul S. Burgoyne (1946-2020) Authors (4)James TurnerShantha Mahadevaiah Arthur P ArnoldRobin Lovell-Badge Development Published 27 October 2020 Crick labsJames TurnerRobin Lovell-BadgeFull details
Human embryogenesis: A comparative perspective Authors (5)Claudia GerriSergio Menchero FernandezShantha MahadevaiahJames TurnerKathy Niakan Annual Review of Cell and Developmental Biology Published 6 October 2020 Crick labsJames TurnerKathy NiakanFull details
A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation Authors (4)Shantha Mahadevaiah Mahesh N SangrithiTakayuki HirotaJames Turner Nature Published 22 October 2020 Crick labs/ facilitiesJames TurnerLight MicroscopyBiological Research FacilityAdvanced SequencingFull details
Advances and challenges in genetic technologies to produce single-sex litters Authors (2)Charlotte DouglasJames Turner PLOS Genetics Published 23 July 2020 Crick labsJames TurnerFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...] Sophia Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes Authors (12)Elias ElinatiAgata ZielinskaAfshan Mccarthy Nada KubikovaValdone MaciulyteShantha Mahadevaiah[...]Andrew Ojarikre Dagan WellsKathy Niakan Melina SchuhJames Turner Nature Communications Published 25 May 2020 Crick labs/ facilitiesJames TurnerKathy NiakanLight MicroscopyExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche Authors (17) Sissy E Wamaitha Katarzyna J GrybelGregorio Alanis LobatoClaudia GerriSugako OgushiAfshan Mccarthy[...] Phil Snell Leila ChristieJulian DownwardJames TurnerKathy Niakan Nature Communications Published 7 February 2020 Crick labs/ facilitiesJames TurnerKathy NiakanJulian DownwardHuman Embryonic Stem CellScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsFull details
Gene expression across mammalian organ development Authors (33)Margarida Cardoso Moreira Jean Halbert Delphine Valloton Britta Velten Chunyan Chen Yi Shao[...] Wolfgang Huber Julie Baker Simon Anders Yong E Zhang Henrik Kaessmann Nature Published 1 July 2019 Crick labsJames TurnerMargarida Cardoso-MoreiraFull details
Sex chromosome effects on male-female differences in mammals Authors (2)Daniel SnellJames Turner Current Biology Published 19 November 2018 Crick labsJames TurnerFull details
SETDB1 links the meiotic DNA damage response to sex chromosome silencing in mice Authors (11)Takayuki Hirota Paul Blakeley Mahesh N SangrithiShantha Mahadevaiah Vesela EnchevaBram SnijdersElias Elinati Obah A Ojarikre Dirk G de RooijKathy NiakanJames Turner Developmental Cell Published 3 December 2018 Crick labs/ facilitiesJames TurnerKathy NiakanProteomicsLight MicroscopyExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details