Publications

Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS

Authors (7)

BMC Research Notes

Published 19 April 2023

Crick labs/ facilities

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Antibody-dependent immune responses elicited by blood stage-malaria infection contribute to protective immunity to the pre-erythrocytic stages

Authors (6)

Current Research in Immunology

Published 1 January 2023

Crick labs/ facilities

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Differential trafficking and expression of PIR proteins in acute and chronic Plasmodium infections

Authors (14)

Maria Giorgalli
Deirdre Cunningham
Malgorzata (Malgorzata) Broncel
Aaron Sait
Thomas E Harrison
Caroline Hosking
[...]
Lauren Sullivan
Faith Uwadiae
Laura Torella
Matthew K Higgins
Jean Langhorne

Frontiers in Cellular and Infection Microbiology

Published 16 June 2022

Crick labs/ facilities

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Individual-level variations in malaria susceptibility and acquisition of clinical protection

Authors (17)

John Joseph Valletta
John Addy
Adam J Reid
Francis M Ndungu
Yaw Bediako
Jedida Mwacharo
[...]
Philip Bejon
Kevin Marsh
Jean Langhorne
Chris I Newbold
Mario Recker

Wellcome Open Research

Published 25 February 2022

Crick labs

Jean Langhorne

Full details

10-year longitudinal study of malaria in children: Insights into acquisition and maintenance of naturally acquired immunity

Authors (16)

John Addy
Yaw Bediako
Francis M Ndungu
John Joseph Valetta
Adam J Reid
Jedida Mwacharo
[...]
Matthew Berriman
Kevin Marsh
Philip Bejon
Mario Recker
Jean Langhorne

Wellcome Open Research

Published 4 February 2022

Crick labs

Jean Langhorne

Full details

Analysis of pir gene expression across the Plasmodium life cycle

Authors (12)

Tim Little
Deirdre Cunningham
Audrey Vandomme
Carlos Talavera Lopez
Sarah Amis
Christopher Alder
[...]
Sarah McLaughlin
Caroline Hosking
George Christophides
Adam J Reid
Jean Langhorne

Malaria Journal

Published 25 November 2021

Crick labs/ facilities

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Editorial: Malaria targeting toolkit: Host-parasite interactions

Authors (5)

Tamasa Araki
Jing-wen Lin
Miguel Prudêncio
Deirdre Cunningham
Takeshi Annoura

Frontiers in Cellular and Infection Microbiology

Published 17 November 2021

Crick labs

Jean Langhorne

Full details

Tissue macrophages and interferon-gamma signalling control blood-stage Plasmodium chabaudi infections derived from mosquito-transmitted parasites

Authors (11)

Katrien Deroost
Christopher Alder
Caroline Hosking
Sarah McLaughlin
Jing Wen Lin
Matthew Lewis
Yolanda Saavedra-Torres
John Addy
Prisca Hill
Maria Giorgalli
Jean Langhorne

Current Research in Immunology

Published 30 July 2021

Crick labs/ facilities

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Determinants of malaria protective immunity in mice immunized with live sporozoites during trimethoprim-sulfamethoxazole prophylaxis

Authors (8)

Charlotte V Hobbs
Tejram Sahu
Jillian Neal
Solomon Conteh
Tatiana Voza
William Borkowsky
Jean Langhorne
Patrick E Duffy

American Journal of Tropical Medicine and Hygiene

Published 1 February 2021

Crick labs

Jean Langhorne

Full details

Structure of the Plasmodium-interspersed repeat proteins of the malaria parasite

Authors (5)

Thomas E Harrison
Adam J Reid
Deirdre Cunningham
Jean Langhorne
Matthew K Higgins

Proceedings of the National Academy of Sciences of USA

Published 15 December 2020

Crick labs

Jean Langhorne

Full details

Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection

Authors (19)

Myriam LR Haltalli
Samuel Watcham
Nicola K Wilson
Kira Eilers
Alexander Lipien
Heather Ang
[...]
Jean Langhorne
Ken R Duffy
Berthold Göttgens
Andrew M Blagborough
Cristina Lo Celso

Nature Cell Biology

Published 1 December 2020

Crick labs/ facilities

Full details

Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

Authors (5)

Scientific Data

Published 4 August 2020

Crick labs

Jean Langhorne

Full details

An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi

Authors (15)

Edward J Marr
Rachel M Milne
Burcu Anar
Gareth Girling
Frank Schwach
Jason P Mooney
[...]
Jean Langhorne
Julian C Rayner
Oliver Billker
Ellen S Bushell
Joanne Thompson

Wellcome Open Research

Published 24 June 2020

Crick labs

Jean Langhorne

Full details

B-cell memory in malaria: Myths and realities

Authors (4)

Damian Mazliah
Francis M Ndungu
Racheal Aye
Jean Langhorne

Immunological Reviews

Published 1 January 2020

Crick labs

Jean Langhorne

Full details

Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection

Authors (6)

Carlos Talavera-López
Yaw Bediako
Jing-Wen Lin
John Joseph Valletta
Mario Recker
Jean Langhorne

Scientific Reports

Published 1 November 2019

Crick labs

Jean Langhorne

Full details

Neutrophil extracellular traps drive inflammatory pathogenesis in malaria

Authors (20)

Sebastian Lorenz Knackstedt
Athina Georgiadou
Falko Apel
Ulrike Abu-Abed
Christopher A Moxon
Aubrey J Cunnington
[...]
Benjamin Mordmüller
Evelin Schwarzer
Volker Brinkmann
Arturo Zychlinsky
Borko Amulic

Science Immunology

Published 18 October 2019

Crick labs

Jean Langhorne

Full details

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Authors (35)

Nature Communications

Published 28 June 2019

Crick labs/ facilities

Full details

Functional antibodies against placental malaria parasites are variant-dependent and differ by geographic region

Authors (13)

Justin Doritchamou
Andrew Teo
Robert Morrison
Gunjan Arora
Jennifer Kwan
Javier Manzella-Lapeira
[...]
Lars Hviid
David L Narum
Alassane Dicko
Michal Fried
Patrick E Duffy

Infection and Immunity

Published 1 July 2019

Crick labs

Jean Langhorne

Full details

Repeated clinical malaria episodes are associated with modification of the immune system in children

Authors (24)

Yaw Bediako
Rhys Adams
Adam J Reid
John Joseph Valletta
Francis M Ndungu
Jan Sodenkamp
[...]
Chris Newbold
Matthew Berriman
Philip Bejon
Kevin Marsh
Jean Langhorne

BMC Medicine

Published 13 March 2019

Crick labs

Jean Langhorne

Full details

Chronic helminth infection does not impair immune response to malaria transmission blocking vaccine Pfs230D1-EPA/Alhydrogel® in mice

Authors (14)

Camila H Coelho
Pedro Henrique Gazzinelli-Guimaraes
Jennifer Howard
Emma Barnafo
Nada AH Alani
Olga Muratova
[...]
David L Narum
Charles Anderson
Jean Langhorne
Thomas B Nutman
Patrick E Duffy

Vaccine

Published 23 January 2019

Crick labs

Jean Langhorne

Full details

Research case studies

Vacancies

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Coronavirus (COVID-19) research

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Malaria Immunology Laboratory
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Publications

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Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS

Antibody-dependent immune responses elicited by blood stage-malaria infection contribute to protective immunity to the pre-erythrocytic stages

Differential trafficking and expression of PIR proteins in acute and chronic Plasmodium infections

Individual-level variations in malaria susceptibility and acquisition of clinical protection

10-year longitudinal study of malaria in children: Insights into acquisition and maintenance of naturally acquired immunity

Analysis of pir gene expression across the Plasmodium life cycle

Editorial: Malaria targeting toolkit: Host-parasite interactions

Tissue macrophages and interferon-gamma signalling control blood-stage Plasmodium chabaudi infections derived from mosquito-transmitted parasites

Determinants of malaria protective immunity in mice immunized with live sporozoites during trimethoprim-sulfamethoxazole prophylaxis

Structure of the Plasmodium-interspersed repeat proteins of the malaria parasite

Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection

Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi

B-cell memory in malaria: Myths and realities

Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection

Neutrophil extracellular traps drive inflammatory pathogenesis in malaria

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Functional antibodies against placental malaria parasites are variant-dependent and differ by geographic region

Repeated clinical malaria episodes are associated with modification of the immune system in children

Chronic helminth infection does not impair immune response to malaria transmission blocking vaccine Pfs230D1-EPA/Alhydrogel® in mice

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Vacancies

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