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Breadcrumb Jean Langhorne Langhorne lab Malaria Immunology Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members PublicationsYear published2023 (1)2022 (4)2021 (3)2020 (5)2019 (7)2018 (6)2017 (5)2016 (7)2015 (7)2014 (7)2013 (5)2012 (8)2011 (7)2010 (9) Facet Year publishedResearch topicsImmunology (42)Infectious Disease (42)Model Organisms (42)Computational & Systems Biology (7)Human Biology & Physiology (5)Chemical Biology & High Throughput (4)Genetics & Genomics (4)Tumour Biology (3)Cell Biology (2)Developmental Biology (2)Genome Integrity & Repair (2)Imaging (2)Signalling & Oncogenes (2)Biochemistry & Proteomics (1)Gene Expression (1)Neurosciences (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (81)Primary research (63)Review (12)Commentary (4)Editorial (1)Method (1) Facet Publication typeJournalPLOS Pathogens (8)PLOS ONE (6)Journal of Immunology (4)Malaria Journal (4)Scientific Reports (4)Wellcome Open Research (4)Frontiers in Immunology (3)Journal of Infectious Diseases (3)BMC Research Notes (2)Cellular Microbiology (2)Current Research in Immunology (2)eLife (2)Frontiers in Cellular and Infection Microbiology (2)Infection and Immunity (2)International Journal for Parasitology (2)Journal of Experimental Medicine (2)Nature Immunology (2)Proceedings of the National Academy of Sciences of the United States of America (2)Vaccine (2)ACS Chemical Biology (1)American Journal of Tropical Medicine and Hygiene (1)BMC Biology (1)BMC Genomics (1)BMC Immunology (1)BMC Medicine (1)Cell (1)Current Opinion in Immunology (1)EBioMedicine (1)Expert Review of Anti-infective Therapy (1)Immunity (1)Immunological Reviews (1)Journal of Leukocyte Biology (1)Molecular and Biochemical Parasitology (1)Nature (1)Nature Cell Biology (1)Nature Communications (1)Nature Microbiology (1)Nature Protocols (1)Proceedings of the National Academy of Sciences of USA (1)Science Immunology (1)Scientific Data (1)Trends in Parasitology (1) Facet Journal Publications Displaying 1 - 20 of 81Last updated : 30 November 2023 02:53 Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS Authors (7)Deirdre Cunningham Adam J ReidCaroline HoskingKatrien DeroostIrene Tumwine Mandy SandersJean Langhorne BMC Research Notes Published 19 April 2023 Crick labs/ facilitiesJean LanghorneFlow CytometryBiological Research FacilityFull details Antibody-dependent immune responses elicited by blood stage-malaria infection contribute to protective immunity to the pre-erythrocytic stages Authors (6)Irene TumwineKatrien DeroostPrisca Hill Sarah McLaughlinCaroline HoskingJean Langhorne Current Research in Immunology Published 1 January 2023 Crick labs/ facilitiesJean LanghorneFlow CytometryBiological Research FacilityFull details Differential trafficking and expression of PIR proteins in acute and chronic Plasmodium infections Authors (14)Maria GiorgalliDeirdre CunninghamMalgorzata (Malgorzata) BroncelAaron Sait Thomas E HarrisonCaroline Hosking[...]Lauren Sullivan Faith Uwadiae Laura Torella Matthew K HigginsJean Langhorne Frontiers in Cellular and Infection Microbiology Published 16 June 2022 Crick labs/ facilitiesJean LanghorneProteomicsElectron MicroscopyLight MicroscopyBiological Research FacilityFull details Individual-level variations in malaria susceptibility and acquisition of clinical protection Authors (17) John Joseph VallettaJohn Addy Adam J Reid Francis M NdunguYaw Bediako Jedida Mwacharo[...] Philip Bejon Kevin Marsh Jean Langhorne Chris I Newbold Mario Recker Wellcome Open Research Published 25 February 2022 Crick labsJean LanghorneFull details 10-year longitudinal study of malaria in children: Insights into acquisition and maintenance of naturally acquired immunity Authors (16)John AddyYaw Bediako Francis M Ndungu John Joseph Valetta Adam J Reid Jedida Mwacharo[...] Matthew Berriman Kevin Marsh Philip Bejon Mario ReckerJean Langhorne Wellcome Open Research Published 4 February 2022 Crick labsJean LanghorneFull details Analysis of pir gene expression across the Plasmodium life cycle Authors (12)Tim LittleDeirdre CunninghamAudrey Vandomme Carlos Talavera Lopez Sarah Amis Christopher Alder[...] Sarah McLaughlinCaroline Hosking George Christophides Adam J Reid Jean Langhorne Malaria Journal Published 25 November 2021 Crick labs/ facilitiesJean LanghorneAdvanced SequencingFull details Editorial: Malaria targeting toolkit: Host-parasite interactions Authors (5) Tamasa Araki Jing-wen Lin Miguel PrudêncioDeirdre Cunningham Takeshi Annoura Frontiers in Cellular and Infection Microbiology Published 17 November 2021 Crick labsJean LanghorneFull details Tissue macrophages and interferon-gamma signalling control blood-stage Plasmodium chabaudi infections derived from mosquito-transmitted parasites Authors (11)Katrien Deroost Christopher AlderCaroline Hosking Sarah McLaughlin Jing Wen LinMatthew Lewis Yolanda Saavedra-TorresJohn AddyPrisca HillMaria Giorgalli Jean Langhorne Current Research in Immunology Published 30 July 2021 Crick labs/ facilitiesJean LanghorneBiological Research FacilityFlow CytometryAdvanced SequencingFull details Determinants of malaria protective immunity in mice immunized with live sporozoites during trimethoprim-sulfamethoxazole prophylaxis Authors (8) Charlotte V Hobbs Tejram Sahu Jillian Neal Solomon Conteh Tatiana Voza William Borkowsky Jean Langhorne Patrick E Duffy American Journal of Tropical Medicine and Hygiene Published 1 February 2021 Crick labsJean LanghorneFull details Structure of the Plasmodium-interspersed repeat proteins of the malaria parasite Authors (5) Thomas E Harrison Adam J ReidDeirdre Cunningham Jean Langhorne Matthew K Higgins Proceedings of the National Academy of Sciences of USA Published 15 December 2020 Crick labsJean LanghorneFull details Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection Authors (19) Myriam LR Haltalli Samuel Watcham Nicola K Wilson Kira Eilers Alexander Lipien Heather Ang[...] Jean Langhorne Ken R Duffy Berthold Göttgens Andrew M Blagborough Cristina Lo Celso Nature Cell Biology Published 1 December 2020 Crick labs/ facilitiesJean LanghorneBiological Research FacilityFull details Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection Authors (5) Yuancun ZhaoCaroline HoskingDeirdre Cunningham Jean Langhorne Jing-Wen Lin Scientific Data Published 4 August 2020 Crick labsJean LanghorneFull details An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi Authors (15) Edward J Marr Rachel M Milne Burcu Anar Gareth Girling Frank Schwach Jason P Mooney[...] Jean Langhorne Julian C Rayner Oliver Billker Ellen S Bushell Joanne Thompson Wellcome Open Research Published 24 June 2020 Crick labsJean LanghorneFull details B-cell memory in malaria: Myths and realities Authors (4)Damian Mazliah Francis M Ndungu Racheal Aye Jean Langhorne Immunological Reviews Published 1 January 2020 Crick labsJean LanghorneFull details Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection Authors (6) Carlos Talavera-LópezYaw Bediako Jing-Wen Lin John Joseph Valletta Mario Recker Jean Langhorne Scientific Reports Published 1 November 2019 Crick labsJean LanghorneFull details Neutrophil extracellular traps drive inflammatory pathogenesis in malaria Authors (20) Sebastian Lorenz Knackstedt Athina Georgiadou Falko Apel Ulrike Abu-Abed Christopher A Moxon Aubrey J Cunnington[...] Benjamin Mordmüller Evelin Schwarzer Volker Brinkmann Arturo Zychlinsky Borko Amulic Science Immunology Published 18 October 2019 Crick labsJean LanghorneFull details Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases Authors (35)Akul SinghaniaChristine GrahamLeona GabrysovaLucia Moreira-TeixeiraEvangelos Stavropoulos Jonathan M Pitt[...]Venizelos PapayannopoulosAndreas Wack Jacques F Banchereau Virginia M PascualAnne O'Garra Nature Communications Published 28 June 2019 Crick labs/ facilitiesAndreas WackVenizelos PapayannopoulosAnne O’GarraJean LanghorneEva FrickelBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryExperimental HistopathologyBiological Research FacilityFull details Functional antibodies against placental malaria parasites are variant-dependent and differ by geographic region Authors (13) Justin Doritchamou Andrew Teo Robert Morrison Gunjan Arora Jennifer Kwan Javier Manzella-Lapeira[...] Lars Hviid David L Narum Alassane Dicko Michal Fried Patrick E Duffy Infection and Immunity Published 1 July 2019 Crick labsJean LanghorneFull details Repeated clinical malaria episodes are associated with modification of the immune system in children Authors (24) Yaw Bediako Rhys Adams Adam J Reid John Joseph Valletta Francis M Ndungu Jan Sodenkamp[...] Chris Newbold Matthew Berriman Philip Bejon Kevin Marsh Jean Langhorne BMC Medicine Published 13 March 2019 Crick labsJean LanghorneFull details Chronic helminth infection does not impair immune response to malaria transmission blocking vaccine Pfs230D1-EPA/Alhydrogel® in mice Authors (14) Camila H Coelho Pedro Henrique Gazzinelli-Guimaraes Jennifer Howard Emma Barnafo Nada AH Alani Olga Muratova[...] David L Narum Charles Anderson Jean Langhorne Thomas B Nutman Patrick E Duffy Vaccine Published 23 January 2019 Crick labsJean LanghorneFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS Authors (7)Deirdre Cunningham Adam J ReidCaroline HoskingKatrien DeroostIrene Tumwine Mandy SandersJean Langhorne BMC Research Notes Published 19 April 2023 Crick labs/ facilitiesJean LanghorneFlow CytometryBiological Research FacilityFull details
Antibody-dependent immune responses elicited by blood stage-malaria infection contribute to protective immunity to the pre-erythrocytic stages Authors (6)Irene TumwineKatrien DeroostPrisca Hill Sarah McLaughlinCaroline HoskingJean Langhorne Current Research in Immunology Published 1 January 2023 Crick labs/ facilitiesJean LanghorneFlow CytometryBiological Research FacilityFull details
Differential trafficking and expression of PIR proteins in acute and chronic Plasmodium infections Authors (14)Maria GiorgalliDeirdre CunninghamMalgorzata (Malgorzata) BroncelAaron Sait Thomas E HarrisonCaroline Hosking[...]Lauren Sullivan Faith Uwadiae Laura Torella Matthew K HigginsJean Langhorne Frontiers in Cellular and Infection Microbiology Published 16 June 2022 Crick labs/ facilitiesJean LanghorneProteomicsElectron MicroscopyLight MicroscopyBiological Research FacilityFull details
Individual-level variations in malaria susceptibility and acquisition of clinical protection Authors (17) John Joseph VallettaJohn Addy Adam J Reid Francis M NdunguYaw Bediako Jedida Mwacharo[...] Philip Bejon Kevin Marsh Jean Langhorne Chris I Newbold Mario Recker Wellcome Open Research Published 25 February 2022 Crick labsJean LanghorneFull details
10-year longitudinal study of malaria in children: Insights into acquisition and maintenance of naturally acquired immunity Authors (16)John AddyYaw Bediako Francis M Ndungu John Joseph Valetta Adam J Reid Jedida Mwacharo[...] Matthew Berriman Kevin Marsh Philip Bejon Mario ReckerJean Langhorne Wellcome Open Research Published 4 February 2022 Crick labsJean LanghorneFull details
Analysis of pir gene expression across the Plasmodium life cycle Authors (12)Tim LittleDeirdre CunninghamAudrey Vandomme Carlos Talavera Lopez Sarah Amis Christopher Alder[...] Sarah McLaughlinCaroline Hosking George Christophides Adam J Reid Jean Langhorne Malaria Journal Published 25 November 2021 Crick labs/ facilitiesJean LanghorneAdvanced SequencingFull details
Editorial: Malaria targeting toolkit: Host-parasite interactions Authors (5) Tamasa Araki Jing-wen Lin Miguel PrudêncioDeirdre Cunningham Takeshi Annoura Frontiers in Cellular and Infection Microbiology Published 17 November 2021 Crick labsJean LanghorneFull details
Tissue macrophages and interferon-gamma signalling control blood-stage Plasmodium chabaudi infections derived from mosquito-transmitted parasites Authors (11)Katrien Deroost Christopher AlderCaroline Hosking Sarah McLaughlin Jing Wen LinMatthew Lewis Yolanda Saavedra-TorresJohn AddyPrisca HillMaria Giorgalli Jean Langhorne Current Research in Immunology Published 30 July 2021 Crick labs/ facilitiesJean LanghorneBiological Research FacilityFlow CytometryAdvanced SequencingFull details
Determinants of malaria protective immunity in mice immunized with live sporozoites during trimethoprim-sulfamethoxazole prophylaxis Authors (8) Charlotte V Hobbs Tejram Sahu Jillian Neal Solomon Conteh Tatiana Voza William Borkowsky Jean Langhorne Patrick E Duffy American Journal of Tropical Medicine and Hygiene Published 1 February 2021 Crick labsJean LanghorneFull details
Structure of the Plasmodium-interspersed repeat proteins of the malaria parasite Authors (5) Thomas E Harrison Adam J ReidDeirdre Cunningham Jean Langhorne Matthew K Higgins Proceedings of the National Academy of Sciences of USA Published 15 December 2020 Crick labsJean LanghorneFull details
Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection Authors (19) Myriam LR Haltalli Samuel Watcham Nicola K Wilson Kira Eilers Alexander Lipien Heather Ang[...] Jean Langhorne Ken R Duffy Berthold Göttgens Andrew M Blagborough Cristina Lo Celso Nature Cell Biology Published 1 December 2020 Crick labs/ facilitiesJean LanghorneBiological Research FacilityFull details
Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection Authors (5) Yuancun ZhaoCaroline HoskingDeirdre Cunningham Jean Langhorne Jing-Wen Lin Scientific Data Published 4 August 2020 Crick labsJean LanghorneFull details
An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi Authors (15) Edward J Marr Rachel M Milne Burcu Anar Gareth Girling Frank Schwach Jason P Mooney[...] Jean Langhorne Julian C Rayner Oliver Billker Ellen S Bushell Joanne Thompson Wellcome Open Research Published 24 June 2020 Crick labsJean LanghorneFull details
B-cell memory in malaria: Myths and realities Authors (4)Damian Mazliah Francis M Ndungu Racheal Aye Jean Langhorne Immunological Reviews Published 1 January 2020 Crick labsJean LanghorneFull details
Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection Authors (6) Carlos Talavera-LópezYaw Bediako Jing-Wen Lin John Joseph Valletta Mario Recker Jean Langhorne Scientific Reports Published 1 November 2019 Crick labsJean LanghorneFull details
Neutrophil extracellular traps drive inflammatory pathogenesis in malaria Authors (20) Sebastian Lorenz Knackstedt Athina Georgiadou Falko Apel Ulrike Abu-Abed Christopher A Moxon Aubrey J Cunnington[...] Benjamin Mordmüller Evelin Schwarzer Volker Brinkmann Arturo Zychlinsky Borko Amulic Science Immunology Published 18 October 2019 Crick labsJean LanghorneFull details
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases Authors (35)Akul SinghaniaChristine GrahamLeona GabrysovaLucia Moreira-TeixeiraEvangelos Stavropoulos Jonathan M Pitt[...]Venizelos PapayannopoulosAndreas Wack Jacques F Banchereau Virginia M PascualAnne O'Garra Nature Communications Published 28 June 2019 Crick labs/ facilitiesAndreas WackVenizelos PapayannopoulosAnne O’GarraJean LanghorneEva FrickelBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryExperimental HistopathologyBiological Research FacilityFull details
Functional antibodies against placental malaria parasites are variant-dependent and differ by geographic region Authors (13) Justin Doritchamou Andrew Teo Robert Morrison Gunjan Arora Jennifer Kwan Javier Manzella-Lapeira[...] Lars Hviid David L Narum Alassane Dicko Michal Fried Patrick E Duffy Infection and Immunity Published 1 July 2019 Crick labsJean LanghorneFull details
Repeated clinical malaria episodes are associated with modification of the immune system in children Authors (24) Yaw Bediako Rhys Adams Adam J Reid John Joseph Valletta Francis M Ndungu Jan Sodenkamp[...] Chris Newbold Matthew Berriman Philip Bejon Kevin Marsh Jean Langhorne BMC Medicine Published 13 March 2019 Crick labsJean LanghorneFull details
Chronic helminth infection does not impair immune response to malaria transmission blocking vaccine Pfs230D1-EPA/Alhydrogel® in mice Authors (14) Camila H Coelho Pedro Henrique Gazzinelli-Guimaraes Jennifer Howard Emma Barnafo Nada AH Alani Olga Muratova[...] David L Narum Charles Anderson Jean Langhorne Thomas B Nutman Patrick E Duffy Vaccine Published 23 January 2019 Crick labsJean LanghorneFull details