epithelial cells

Jean-Paul Vincent : Modulation of Wnt signaling

Introduction

Mis-regulation of Wnt signalling is associated with a variety of diseases.

Wnts form a class of signalling proteins that orchestrate cell fate decisions, growth and stem cell maintenance during development and adulthood. Mis-regulation of Wnt signalling is associated with a variety of diseases, including cancer and neurodegeneration.

We investigate the mechanisms that modulate the production, spread and activity of this important signal. Some of our recent achievements include uncovering the role of retrograde transport in Wnt secretion, characterising the role of endocytosis in Wnt signalling, demonstrating that Wnts do not necessarily need to spread and showing that Notum suppresses Wnt activity by enzymatically removing an essential lipid moiety.