Publications

Structural analysis and development of Notum fragment screening hits

Authors (21)

Elliott D Bayle
James Sipthorp
Svend Kjaer
Jean-Paul Vincent
Paul V Fish
Yuguang Zhao
[...]
Artur Costa
Magda Bictash
Patricia C Salinas
Paul Whiting
E Yvonne Jones

ACS Chemical Neuroscience

Published 6 July 2022

Crick labs/ facilities

Full details

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Authors (24)

James Sipthorp
Elliott D Bayle
Fredrik Svensson
Svend Kjaer
Steven Howell
Bram Snijders
[...]
Reinis R Ruza
Magda Bictash
Patricia C Salinas
E Yvonne Jones
Paul Whiting

Journal of Medicinal Chemistry

Published 26 May 2022

Crick labs/ facilities

Full details

Mechanical constraints to cell-cycle progression in a pseudostratified epithelium

Authors (9)

Sophie Hecht
Dominik Schienstock
Carles Recasens Alvarez
Matt Smith
Guillaume Salbreux
Jean-Paul Vincent
Gantas Perez-Mockus
Sara Merino-Aceituno
Pierre Degond

Current Biology

Published 9 May 2022

Crick labs

Full details

Rapid and robust optogenetic control of gene expression in Drosophila

Authors (11)

Sophie Hodara Herszterg
Anqi Huang
Cyrille Alexandre
Jean-Paul Vincent
Florencia di Pietro
Floris Bosveld
Lucas Sancéré
Stéphane Pelletier
Amina Joudat
Varun Kapoor
Yohanns Bellaïche

Developmental Cell

Published 20 December 2021

Crick labs

Jean-Paul Vincent

Full details

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Authors (36)

Paul V Fish
Jean-Paul Vincent
Dustin J Flanagan
Nalle Pentinmikko
Kalle Luopajärvi
Nicky J Willis
[...]
E Yvonne Jones
Ari Ristimäki
Simon J Leedham
Pekka Katajisto
Owen J Sansom

Nature

Published 17 June 2021

Crick labs

Jean-Paul Vincent

Full details

One-step CRISPR-Cas9 protocol for the generation of plug & play conditional knockouts in Drosophila melanogaster

Authors (3)

STAR Protocols

Published 18 June 2021

Crick labs

Jean-Paul Vincent

Full details

Carboxylesterase Notum is a druggable target to modulate Wnt signaling

Authors (9)

Elliott D Bayle
Fredrik Svensson
Jean-Paul Vincent
Paul V Fish
Benjamin N Atkinson
David Steadman
Nicky J Willis
Hannah L Woodward
Paul Whiting

Journal of Medicinal Chemistry

Published 22 April 2021

Crick labs

Jean-Paul Vincent

Full details

Generation of extracellular morphogen gradients: the case for diffusion

Authors (2)

Nature Reviews Genetics

Published 1 June 2021

Crick labs

Jean-Paul Vincent

Full details

Notum deacylates octanoylated ghrelin

Authors (11)

Laura Nadine Schuhmacher
Morgan Roberts
Satoshi Kakugawa
Ganka Bineva-Todd
Steve Howell
Nicola O'Reilly
Bram Snijders
Jean-Paul Vincent
Yuguang Zhao
Christine Perret
E Yvonne Jones

Molecular Metabolism

Published 1 July 2021

Crick labs/ facilities

Full details

Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition

Authors (7)

Nature Cell Biology

Published 1 February 2021

Crick labs/ facilities

Full details

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Authors (18)

Fredrik Svensson
James Sipthorp
Svend Kjaer
Jean-Paul Vincent
Paul V Fish
William Mahy
[...]
Amy Monaghan
Magda Bictash
Patricia C Salinas
Paul Whiting
E Yvonne Jones

Journal of Medicinal Chemistry

Published 12 November 2020

Crick labs/ facilities

Full details

Patterning and growth control in vivo by an engineered GFP gradient

Authors (5)

Science

Published 16 October 2020

Crick labs

Full details

Frizzled-dependent planar cell polarity without secreted Wnt ligands

Authors (7)

Joyce Yu
Cyrille Alexandre
Jean-Paul Vincent
Ian Mcgough
Aude Maugarny-Calès
Stéphane Pelletier
Yohanns Bellaiche

Developmental Cell

Published 14 September 2020

Crick labs

Jean-Paul Vincent

Full details

Glypicans shield the Wnt lipid moiety to enable signalling at a distance

Authors (10)

Ian Mcgough
Dhira Joshi
Nicola O'Reilly
Jean-Paul Vincent
Luca Vecchia
Benjamin Bishop
Tomas Malinauskas
Karen Beckett
Christian Siebold
E Yvonne Jones

Nature

Published 3 September 2020

Crick labs/ facilities

Full details

Incompressible limit of a continuum model of tissue growth with segregation for two cell populations

Authors (2)

S Hecht
Jean-Paul Vincent

Mathematical Biosciences and Engineering

Published 22 June 2019

Crick labs

Jean-Paul Vincent

Full details

Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells

Authors (6)

Jean-Paul Vincent
Cyrille Alexandre
Luis Alberto Baena-Lopez
Lewis Arthurton
Marcus Bischoff
Reuben McGregor

Development

Published 4 December 2018

Crick labs

Jean-Paul Vincent

Full details

Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

Authors (2)

Nature Communications

Published 7 November 2018

Crick labs

Jean-Paul Vincent

Full details

EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development

Authors (3)

Samuel Crossman
Jean-Paul Vincent
Sebastian J Streichan

PLOS Biology

Published 31 October 2018

Crick labs/ facilities

Full details

Developmental biology: Morphogen in a dish

Authors (3)

Current Biology

Published 9 July 2018

Crick labs

Full details

APC moonlights to prevent wnt signalosome assembly

Authors (2)

Developmental Cell

Published 12 March 2018

Crick labs

Jean-Paul Vincent

Full details

Research case studies

Vacancies

Pathway to Discovery

Coronavirus (COVID-19) research

About us

Vincent lab
Epithelial Cell Interactions Laboratory
: Publications

Lab content

Publications

Year published

Research topics

Publication type

Journal

Structural analysis and development of Notum fragment screening hits

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Mechanical constraints to cell-cycle progression in a pseudostratified epithelium

Rapid and robust optogenetic control of gene expression in Drosophila

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

One-step CRISPR-Cas9 protocol for the generation of plug & play conditional knockouts in Drosophila melanogaster

Carboxylesterase Notum is a druggable target to modulate Wnt signaling

Generation of extracellular morphogen gradients: the case for diffusion

Notum deacylates octanoylated ghrelin

Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Patterning and growth control in vivo by an engineered GFP gradient

Frizzled-dependent planar cell polarity without secreted Wnt ligands

Glypicans shield the Wnt lipid moiety to enable signalling at a distance

Incompressible limit of a continuum model of tissue growth with segregation for two cell populations

Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells

Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development

Developmental biology: Morphogen in a dish

APC moonlights to prevent wnt signalosome assembly

The Francis Crick Institute is a unique partnership between

Research case studies

Vacancies

Pathway to Discovery

Coronavirus (COVID-19) research

About us

Lab content

Publications

Year published

Research topics

Publication type

Journal

Publications

Share the page

The Francis Crick Institute is a unique partnership between