Publications

The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level

Authors (6)

Developmental Cell

Published 23 October 2023

Crick labs/ facilities

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The logistics of Wnt production and delivery

Authors (3)

Current Topics in Developmental Biology

Published 24 March 2023

Crick labs

Jean-Paul Vincent

Full details

Structural analysis and development of Notum fragment screening hits

Authors (21)

Yuguang Zhao
William Mahy
Nicky J Willis
Hannah L Woodward
David Steadman
Elliott D Bayle
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
Paul V Fish
E Yvonne Jones

ACS Chemical Neuroscience

Published 6 July 2022

Crick labs/ facilities

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Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Authors (24)

Nicky J Willis
William Mahy
James Sipthorp
Yuguang Zhao
Hannah L Woodward
Benjamin N Atkinson
[...]
Patricia C Salinas
Jean-Paul Vincent
E Yvonne Jones
Paul Whiting
Paul V Fish

Journal of Medicinal Chemistry

Published 26 May 2022

Crick labs/ facilities

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Mechanical constraints to cell-cycle progression in a pseudostratified epithelium

Authors (9)

Sophie Hecht
Gantas Perez Mockus
Dominik Schienstock
Carles Recasens Alvarez
Sara Merino-Aceituno
Matt Smith
Guillaume Salbreux
Pierre Degond
Jean-Paul Vincent

Current Biology

Published 9 May 2022

Crick labs

Full details

Rapid and robust optogenetic control of gene expression in Drosophila

Authors (11)

Florencia di Pietro
Sophie Hodara Herszterg
Anqi Huang
Floris Bosveld
Cyrille Alexandre
Lucas Sancéré
Stéphane Pelletier
Amina Joudat
Varun Kapoor
Jean-Paul Vincent
Yohanns Bellaïche

Developmental Cell

Published 20 December 2021

Crick labs

Jean-Paul Vincent

Full details

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Authors (36)

Dustin J Flanagan
Nalle Pentinmikko
Kalle Luopajärvi
Nicky J Willis
Kathryn Gilroy
Alexander P Raven
[...]
Simon J Leedham
Paul V Fish
Jean-Paul Vincent
Pekka Katajisto
Owen J Sansom

Nature

Published 17 June 2021

Crick labs

Jean-Paul Vincent

Full details

One-step CRISPR-Cas9 protocol for the generation of plug & play conditional knockouts in Drosophila melanogaster

Authors (3)

STAR Protocols

Published 18 June 2021

Crick labs

Jean-Paul Vincent

Full details

Carboxylesterase Notum is a druggable target to modulate Wnt signaling

Authors (9)

Elliott D Bayle
Fredrik Svensson
Benjamin N Atkinson
David Steadman
Nicky J Willis
Hannah L Woodward
Paul Whiting
Jean-Paul Vincent
Paul V Fish

Journal of Medicinal Chemistry

Published 22 April 2021

Crick labs

Jean-Paul Vincent

Full details

Generation of extracellular morphogen gradients: the case for diffusion

Authors (2)

Nature Reviews Genetics

Published 1 June 2021

Crick labs

Jean-Paul Vincent

Full details

Notum deacylates octanoylated ghrelin

Authors (11)

Yuguang Zhao
Laura Nadine Schuhmacher
Morgan Roberts
Satoshi Kakugawa
Ganka Bineva-Todd
Steve Howell
Nicola O'Reilly
Christine Perret
Bram Snijders
Jean-Paul Vincent
E Yvonne Jones

Molecular Metabolism

Published 1 July 2021

Crick labs/ facilities

Full details

Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition

Authors (7)

Nature Cell Biology

Published 1 February 2021

Crick labs/ facilities

Full details

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Authors (18)

William Mahy
Nicky J Willis
Yuguang Zhao
Hannah L Woodward
Fredrik Svensson
James Sipthorp
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
E Yvonne Jones
Paul V Fish

Journal of Medicinal Chemistry

Published 12 November 2020

Crick labs/ facilities

Full details

Patterning and growth control in vivo by an engineered GFP gradient

Authors (5)

Science

Published 16 October 2020

Crick labs

Full details

Frizzled-dependent planar cell polarity without secreted Wnt ligands

Authors (7)

Joyce Yu
Aude Maugarny-Calès
Stéphane Pelletier
Cyrille Alexandre
Yohanns Bellaiche
Jean-Paul Vincent
Ian Mcgough

Developmental Cell

Published 14 September 2020

Crick labs

Jean-Paul Vincent

Full details

Glypicans shield the Wnt lipid moiety to enable signalling at a distance

Authors (10)

Ian Mcgough
Luca Vecchia
Benjamin Bishop
Tomas Malinauskas
Karen Beckett
Dhira Joshi
Nicola O'Reilly
Christian Siebold
E Yvonne Jones
Jean-Paul Vincent

Nature

Published 3 September 2020

Crick labs

Jean-Paul Vincent

Full details

Incompressible limit of a continuum model of tissue growth with segregation for two cell populations

Authors (4)

A Chertock
P Degond
S Hecht
Jean-Paul Vincent

Mathematical Biosciences and Engineering

Published 22 June 2019

Crick labs

Jean-Paul Vincent

Full details

Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells

Authors (6)

Luis Alberto Baena-Lopez
Lewis Arthurton
Marcus Bischoff
Jean-Paul Vincent
Cyrille Alexandre
Reuben McGregor

Development

Published 4 December 2018

Crick labs

Jean-Paul Vincent

Full details

Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

Authors (2)

Nature Communications

Published 7 November 2018

Crick labs

Jean-Paul Vincent

Full details

EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development

Authors (3)

Samuel Crossman
Sebastian J Streichan
Jean-Paul Vincent

PLOS Biology

Published 31 October 2018

Crick labs/ facilities

Full details

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: Publications

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Publications

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The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level

The logistics of Wnt production and delivery

Structural analysis and development of Notum fragment screening hits

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Mechanical constraints to cell-cycle progression in a pseudostratified epithelium

Rapid and robust optogenetic control of gene expression in Drosophila

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

One-step CRISPR-Cas9 protocol for the generation of plug & play conditional knockouts in Drosophila melanogaster

Carboxylesterase Notum is a druggable target to modulate Wnt signaling

Generation of extracellular morphogen gradients: the case for diffusion

Notum deacylates octanoylated ghrelin

Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Patterning and growth control in vivo by an engineered GFP gradient

Frizzled-dependent planar cell polarity without secreted Wnt ligands

Glypicans shield the Wnt lipid moiety to enable signalling at a distance

Incompressible limit of a continuum model of tissue growth with segregation for two cell populations

Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells

Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development

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