Vincent lab
Epithelial Cell Interactions Laboratory
: Publications

Publications

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Last updated : 19 April 2024 03:39

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Authors (24)

Nicky J Willis
William Mahy
James Sipthorp
Yuguang Zhao
Hannah L Woodward
Benjamin N Atkinson
[...]
Patricia C Salinas
Jean-Paul Vincent
E Yvonne Jones
Paul Whiting
Paul V Fish

Journal of Medicinal Chemistry

Published 26 May 2022

Crick labs/ facilities

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Carboxylesterase Notum is a druggable target to modulate Wnt signaling

Authors (9)

Elliott D Bayle
Fredrik Svensson
Benjamin N Atkinson
David Steadman
Nicky J Willis
Hannah L Woodward
Paul Whiting
Jean-Paul Vincent
Paul V Fish

Journal of Medicinal Chemistry

Published 22 April 2021

Crick labs

Jean-Paul Vincent

Full details

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Authors (18)

William Mahy
Nicky J Willis
Yuguang Zhao
Hannah L Woodward
Fredrik Svensson
James Sipthorp
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
E Yvonne Jones
Paul V Fish

Journal of Medicinal Chemistry

Published 12 November 2020

Crick labs/ facilities

Full details

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Postdoctoral clinical fellows

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Vincent lab
Epithelial Cell Interactions Laboratory
: Publications

Lab content

Publications

Year published

Research topics

Publication type

Journal

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Carboxylesterase Notum is a druggable target to modulate Wnt signaling

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

The Francis Crick Institute is a unique partnership between

Research case studies

Postdoctoral clinical fellows

Hello Brain!

News and reports

About us

Lab content

Publications

Year published

Research topics

Publication type

Journal

Publications

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Carboxylesterase Notum is a druggable target to modulate Wnt signaling

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

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