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Breadcrumb Jean Paul Vincent Vincent lab Epithelial Cell Interactions Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies False-colored nuclei of the embryonic epidermis of Drosophila (credit: Sam Crossman) Toggle to view hero caption PublicationsYear published2022 (1)2021 (1)2020 (1) Facet Year publishedResearch topicsCell Biology (3)Developmental Biology (3)Genetics & Genomics (3)Imaging (3)Neurosciences (3)Signalling & Oncogenes (3)Synthetic Biology (3)Chemical Biology & High Throughput (2)Structural Biology & Biophysics (2)Biochemistry & Proteomics (1)Computational & Systems Biology (1) (-)Model Organisms (3) Facet Research topicsPublication typeJournal article (3)Primary research (2)Review (1) Facet Publication typeJournal (-)Journal of Medicinal Chemistry (3) Facet Journal Publications Displaying 1 - 3 of 3Last updated : 18 April 2024 02:51 Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit Authors (24) Nicky J Willis William Mahy James Sipthorp Yuguang Zhao Hannah L Woodward Benjamin N Atkinson[...] Patricia C SalinasJean-Paul Vincent E Yvonne Jones Paul Whiting Paul V Fish Journal of Medicinal Chemistry Published 26 May 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyProteomicsTranslation teamCell ServicesFull details Carboxylesterase Notum is a druggable target to modulate Wnt signaling Authors (9) Elliott D Bayle Fredrik Svensson Benjamin N Atkinson David Steadman Nicky J Willis Hannah L Woodward Paul WhitingJean-Paul Vincent Paul V Fish Journal of Medicinal Chemistry Published 22 April 2021 Crick labsJean-Paul VincentFull details 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit Authors (18) William Mahy Nicky J Willis Yuguang Zhao Hannah L Woodward Fredrik Svensson James Sipthorp[...] Patricia C Salinas Paul WhitingJean-Paul Vincent E Yvonne Jones Paul V Fish Journal of Medicinal Chemistry Published 12 November 2020 Crick labs/ facilitiesJean-Paul VincentStructural BiologyFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit Authors (24) Nicky J Willis William Mahy James Sipthorp Yuguang Zhao Hannah L Woodward Benjamin N Atkinson[...] Patricia C SalinasJean-Paul Vincent E Yvonne Jones Paul Whiting Paul V Fish Journal of Medicinal Chemistry Published 26 May 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyProteomicsTranslation teamCell ServicesFull details
Carboxylesterase Notum is a druggable target to modulate Wnt signaling Authors (9) Elliott D Bayle Fredrik Svensson Benjamin N Atkinson David Steadman Nicky J Willis Hannah L Woodward Paul WhitingJean-Paul Vincent Paul V Fish Journal of Medicinal Chemistry Published 22 April 2021 Crick labsJean-Paul VincentFull details
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit Authors (18) William Mahy Nicky J Willis Yuguang Zhao Hannah L Woodward Fredrik Svensson James Sipthorp[...] Patricia C Salinas Paul WhitingJean-Paul Vincent E Yvonne Jones Paul V Fish Journal of Medicinal Chemistry Published 12 November 2020 Crick labs/ facilitiesJean-Paul VincentStructural BiologyFull details