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Breadcrumb Jean Paul Vincent Vincent lab Epithelial Cell Interactions Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies False-colored nuclei of the embryonic epidermis of Drosophila (credit: Sam Crossman) Toggle to view hero caption PublicationsYear published2023 (2)2022 (3)2021 (7)2020 (4)2019 (1)2018 (5)2017 (3)2016 (7) Facet Year publishedResearch topicsDevelopmental Biology (32)Genetics & Genomics (32)Imaging (32)Model Organisms (32)Neurosciences (32)Signalling & Oncogenes (32)Synthetic Biology (32)Structural Biology & Biophysics (8)Computational & Systems Biology (7)Chemical Biology & High Throughput (6)Biochemistry & Proteomics (3)Cell Cycle & Chromosomes (1)Gene Expression (1)Tumour Biology (1) (-)Cell Biology (32) Facet Research topicsPublication typeJournal article (32)Primary research (23)Review (6)Commentary (2)Method (1) Facet Publication typeJournalDevelopment (4)Developmental Cell (4)Current Biology (3)Journal of Medicinal Chemistry (3)Nature (2)Nature Cell Biology (2)ACS Chemical Neuroscience (1)Communications in Mathematical Sciences (1)Current Topics in Developmental Biology (1)eLife (1)Genetics (1)Mathematical Biosciences and Engineering (1)Molecular Metabolism (1)Nature Communications (1)Nature Reviews Genetics (1)Nature Structural & Molecular Biology (1)PLOS Biology (1)Science (1)STAR Protocols (1)Trends in Cell Biology (1) Facet Journal Publications Displaying 1 - 20 of 32Last updated : 20 April 2024 03:14 The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level Authors (6)Gantas Perez MockusLuca CocconiCyrille AlexandreBirgit AerneGuillaume SalbreuxJean-Paul Vincent Developmental Cell Published 23 October 2023 Crick labs/ facilitiesJean-Paul VincentNic TaponGuillaume SalbreuxLight MicroscopyAdvanced SequencingFull details The logistics of Wnt production and delivery Authors (3)Ines Alvarez Rodrigo David WillnowJean-Paul Vincent Current Topics in Developmental Biology Published 24 March 2023 Crick labsJean-Paul VincentFull details Structural analysis and development of Notum fragment screening hits Authors (21) Yuguang Zhao William Mahy Nicky J Willis Hannah L Woodward David Steadman Elliott D Bayle[...] Patricia C Salinas Paul WhitingJean-Paul Vincent Paul V Fish E Yvonne Jones ACS Chemical Neuroscience Published 6 July 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyCell ServicesFull details Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit Authors (24) Nicky J Willis William Mahy James Sipthorp Yuguang Zhao Hannah L Woodward Benjamin N Atkinson[...] Patricia C SalinasJean-Paul Vincent E Yvonne Jones Paul Whiting Paul V Fish Journal of Medicinal Chemistry Published 26 May 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyProteomicsTranslation teamCell ServicesFull details Mechanical constraints to cell-cycle progression in a pseudostratified epithelium Authors (9) Sophie HechtGantas Perez Mockus Dominik SchienstockCarles Recasens Alvarez Sara Merino-AceitunoMatt SmithGuillaume Salbreux Pierre DegondJean-Paul Vincent Current Biology Published 9 May 2022 Crick labsJean-Paul VincentGuillaume SalbreuxFull details Rapid and robust optogenetic control of gene expression in Drosophila Authors (11) Florencia di PietroSophie Hodara Herszterg Anqi Huang Floris BosveldCyrille Alexandre Lucas Sancéré Stéphane Pelletier Amina Joudat Varun KapoorJean-Paul Vincent Yohanns Bellaïche Developmental Cell Published 20 December 2021 Crick labsJean-Paul VincentFull details NOTUM from Apc-mutant cells biases clonal competition to initiate cancer Authors (36) Dustin J Flanagan Nalle Pentinmikko Kalle Luopajärvi Nicky J Willis Kathryn Gilroy Alexander P Raven[...] Simon J Leedham Paul V FishJean-Paul Vincent Pekka Katajisto Owen J Sansom Nature Published 17 June 2021 Crick labsJean-Paul VincentFull details One-step CRISPR-Cas9 protocol for the generation of plug & play conditional knockouts in Drosophila melanogaster Authors (3)Joyce YuJean-Paul VincentIan Mcgough STAR Protocols Published 18 June 2021 Crick labsJean-Paul VincentFull details Carboxylesterase Notum is a druggable target to modulate Wnt signaling Authors (9) Elliott D Bayle Fredrik Svensson Benjamin N Atkinson David Steadman Nicky J Willis Hannah L Woodward Paul WhitingJean-Paul Vincent Paul V Fish Journal of Medicinal Chemistry Published 22 April 2021 Crick labsJean-Paul VincentFull details Generation of extracellular morphogen gradients: the case for diffusion Authors (2)Kristina StapornwongkulJean-Paul Vincent Nature Reviews Genetics Published 1 June 2021 Crick labsJean-Paul VincentFull details Notum deacylates octanoylated ghrelin Authors (11) Yuguang ZhaoLaura Nadine SchuhmacherMorgan Roberts Satoshi KakugawaGanka Bineva-Todd Steve HowellNicola O'Reilly Christine PerretBram SnijdersJean-Paul Vincent E Yvonne Jones Molecular Metabolism Published 1 July 2021 Crick labs/ facilitiesJean-Paul VincentProteomicsFull details Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition Authors (7)Carles Recasens AlvarezCyrille AlexandreJoanna Kirkpatrick Hisashi Nojima David J HuelsBram SnijdersJean-Paul Vincent Nature Cell Biology Published 1 February 2021 Crick labs/ facilitiesJean-Paul VincentProteomicsFull details 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit Authors (18) William Mahy Nicky J Willis Yuguang Zhao Hannah L Woodward Fredrik Svensson James Sipthorp[...] Patricia C Salinas Paul WhitingJean-Paul Vincent E Yvonne Jones Paul V Fish Journal of Medicinal Chemistry Published 12 November 2020 Crick labs/ facilitiesJean-Paul VincentStructural BiologyFull details Patterning and growth control in vivo by an engineered GFP gradient Authors (5)Kristina StapornwongkulMarc De GennesLuca CocconiGuillaume SalbreuxJean-Paul Vincent Science Published 16 October 2020 Crick labsJean-Paul VincentGuillaume SalbreuxFull details Frizzled-dependent planar cell polarity without secreted Wnt ligands Authors (7)Joyce Yu Aude Maugarny-Calès Stéphane PelletierCyrille Alexandre Yohanns BellaicheJean-Paul VincentIan Mcgough Developmental Cell Published 14 September 2020 Crick labsJean-Paul VincentFull details Glypicans shield the Wnt lipid moiety to enable signalling at a distance Authors (10)Ian Mcgough Luca Vecchia Benjamin Bishop Tomas Malinauskas Karen BeckettDhira JoshiNicola O'Reilly Christian Siebold E Yvonne JonesJean-Paul Vincent Nature Published 3 September 2020 Crick labsJean-Paul VincentFull details Incompressible limit of a continuum model of tissue growth with segregation for two cell populations Authors (4) A Chertock P Degond S HechtJean-Paul Vincent Mathematical Biosciences and Engineering Published 22 June 2019 Crick labsJean-Paul VincentFull details Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells Authors (6) Luis Alberto Baena-Lopez Lewis Arthurton Marcus BischoffJean-Paul VincentCyrille Alexandre Reuben McGregor Development Published 4 December 2018 Crick labsJean-Paul VincentFull details Epithelial cells release adenosine to promote local TNF production in response to polarity disruption Authors (2)Ingrid PoernbacherJean-Paul Vincent Nature Communications Published 7 November 2018 Crick labsJean-Paul VincentFull details EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development Authors (3)Samuel Crossman Sebastian J StreichanJean-Paul Vincent PLOS Biology Published 31 October 2018 Crick labs/ facilitiesJean-Paul VincentLight MicroscopyFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level Authors (6)Gantas Perez MockusLuca CocconiCyrille AlexandreBirgit AerneGuillaume SalbreuxJean-Paul Vincent Developmental Cell Published 23 October 2023 Crick labs/ facilitiesJean-Paul VincentNic TaponGuillaume SalbreuxLight MicroscopyAdvanced SequencingFull details
The logistics of Wnt production and delivery Authors (3)Ines Alvarez Rodrigo David WillnowJean-Paul Vincent Current Topics in Developmental Biology Published 24 March 2023 Crick labsJean-Paul VincentFull details
Structural analysis and development of Notum fragment screening hits Authors (21) Yuguang Zhao William Mahy Nicky J Willis Hannah L Woodward David Steadman Elliott D Bayle[...] Patricia C Salinas Paul WhitingJean-Paul Vincent Paul V Fish E Yvonne Jones ACS Chemical Neuroscience Published 6 July 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyCell ServicesFull details
Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit Authors (24) Nicky J Willis William Mahy James Sipthorp Yuguang Zhao Hannah L Woodward Benjamin N Atkinson[...] Patricia C SalinasJean-Paul Vincent E Yvonne Jones Paul Whiting Paul V Fish Journal of Medicinal Chemistry Published 26 May 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyProteomicsTranslation teamCell ServicesFull details
Mechanical constraints to cell-cycle progression in a pseudostratified epithelium Authors (9) Sophie HechtGantas Perez Mockus Dominik SchienstockCarles Recasens Alvarez Sara Merino-AceitunoMatt SmithGuillaume Salbreux Pierre DegondJean-Paul Vincent Current Biology Published 9 May 2022 Crick labsJean-Paul VincentGuillaume SalbreuxFull details
Rapid and robust optogenetic control of gene expression in Drosophila Authors (11) Florencia di PietroSophie Hodara Herszterg Anqi Huang Floris BosveldCyrille Alexandre Lucas Sancéré Stéphane Pelletier Amina Joudat Varun KapoorJean-Paul Vincent Yohanns Bellaïche Developmental Cell Published 20 December 2021 Crick labsJean-Paul VincentFull details
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer Authors (36) Dustin J Flanagan Nalle Pentinmikko Kalle Luopajärvi Nicky J Willis Kathryn Gilroy Alexander P Raven[...] Simon J Leedham Paul V FishJean-Paul Vincent Pekka Katajisto Owen J Sansom Nature Published 17 June 2021 Crick labsJean-Paul VincentFull details
One-step CRISPR-Cas9 protocol for the generation of plug & play conditional knockouts in Drosophila melanogaster Authors (3)Joyce YuJean-Paul VincentIan Mcgough STAR Protocols Published 18 June 2021 Crick labsJean-Paul VincentFull details
Carboxylesterase Notum is a druggable target to modulate Wnt signaling Authors (9) Elliott D Bayle Fredrik Svensson Benjamin N Atkinson David Steadman Nicky J Willis Hannah L Woodward Paul WhitingJean-Paul Vincent Paul V Fish Journal of Medicinal Chemistry Published 22 April 2021 Crick labsJean-Paul VincentFull details
Generation of extracellular morphogen gradients: the case for diffusion Authors (2)Kristina StapornwongkulJean-Paul Vincent Nature Reviews Genetics Published 1 June 2021 Crick labsJean-Paul VincentFull details
Notum deacylates octanoylated ghrelin Authors (11) Yuguang ZhaoLaura Nadine SchuhmacherMorgan Roberts Satoshi KakugawaGanka Bineva-Todd Steve HowellNicola O'Reilly Christine PerretBram SnijdersJean-Paul Vincent E Yvonne Jones Molecular Metabolism Published 1 July 2021 Crick labs/ facilitiesJean-Paul VincentProteomicsFull details
Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition Authors (7)Carles Recasens AlvarezCyrille AlexandreJoanna Kirkpatrick Hisashi Nojima David J HuelsBram SnijdersJean-Paul Vincent Nature Cell Biology Published 1 February 2021 Crick labs/ facilitiesJean-Paul VincentProteomicsFull details
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit Authors (18) William Mahy Nicky J Willis Yuguang Zhao Hannah L Woodward Fredrik Svensson James Sipthorp[...] Patricia C Salinas Paul WhitingJean-Paul Vincent E Yvonne Jones Paul V Fish Journal of Medicinal Chemistry Published 12 November 2020 Crick labs/ facilitiesJean-Paul VincentStructural BiologyFull details
Patterning and growth control in vivo by an engineered GFP gradient Authors (5)Kristina StapornwongkulMarc De GennesLuca CocconiGuillaume SalbreuxJean-Paul Vincent Science Published 16 October 2020 Crick labsJean-Paul VincentGuillaume SalbreuxFull details
Frizzled-dependent planar cell polarity without secreted Wnt ligands Authors (7)Joyce Yu Aude Maugarny-Calès Stéphane PelletierCyrille Alexandre Yohanns BellaicheJean-Paul VincentIan Mcgough Developmental Cell Published 14 September 2020 Crick labsJean-Paul VincentFull details
Glypicans shield the Wnt lipid moiety to enable signalling at a distance Authors (10)Ian Mcgough Luca Vecchia Benjamin Bishop Tomas Malinauskas Karen BeckettDhira JoshiNicola O'Reilly Christian Siebold E Yvonne JonesJean-Paul Vincent Nature Published 3 September 2020 Crick labsJean-Paul VincentFull details
Incompressible limit of a continuum model of tissue growth with segregation for two cell populations Authors (4) A Chertock P Degond S HechtJean-Paul Vincent Mathematical Biosciences and Engineering Published 22 June 2019 Crick labsJean-Paul VincentFull details
Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells Authors (6) Luis Alberto Baena-Lopez Lewis Arthurton Marcus BischoffJean-Paul VincentCyrille Alexandre Reuben McGregor Development Published 4 December 2018 Crick labsJean-Paul VincentFull details
Epithelial cells release adenosine to promote local TNF production in response to polarity disruption Authors (2)Ingrid PoernbacherJean-Paul Vincent Nature Communications Published 7 November 2018 Crick labsJean-Paul VincentFull details
EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development Authors (3)Samuel Crossman Sebastian J StreichanJean-Paul Vincent PLOS Biology Published 31 October 2018 Crick labs/ facilitiesJean-Paul VincentLight MicroscopyFull details