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Breadcrumb Jean Paul Vincent Vincent lab Epithelial Cell Interactions Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies False-colored nuclei of the embryonic epidermis of Drosophila (credit: Sam Crossman) Toggle to view hero caption PublicationsYear published2023 (1)2022 (1)2021 (2)2020 (2) Facet Year publishedResearch topicsCell Biology (6)Developmental Biology (6)Genetics & Genomics (6)Imaging (6)Model Organisms (6)Neurosciences (6)Signalling & Oncogenes (6)Synthetic Biology (6)Structural Biology & Biophysics (5)Computational & Systems Biology (4)Biochemistry & Proteomics (3)Cell Cycle & Chromosomes (1)Gene Expression (1)Tumour Biology (1) (-)Chemical Biology & High Throughput (6) Facet Research topicsPublication typeJournal article (6)Primary research (6) Facet Publication typeJournalJournal of Medicinal Chemistry (2)Developmental Cell (1)Molecular Metabolism (1)Nature (1)Nature Cell Biology (1) Facet Journal Publications Displaying 1 - 6 of 6Last updated : 20 April 2024 02:50 The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level Authors (6)Gantas Perez MockusLuca CocconiCyrille AlexandreBirgit AerneGuillaume SalbreuxJean-Paul Vincent Developmental Cell Published 23 October 2023 Crick labs/ facilitiesJean-Paul VincentNic TaponGuillaume SalbreuxLight MicroscopyAdvanced SequencingFull details Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit Authors (24) Nicky J Willis William Mahy James Sipthorp Yuguang Zhao Hannah L Woodward Benjamin N Atkinson[...] Patricia C SalinasJean-Paul Vincent E Yvonne Jones Paul Whiting Paul V Fish Journal of Medicinal Chemistry Published 26 May 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyProteomicsTranslation teamCell ServicesFull details Notum deacylates octanoylated ghrelin Authors (11) Yuguang ZhaoLaura Nadine SchuhmacherMorgan Roberts Satoshi KakugawaGanka Bineva-Todd Steve HowellNicola O'Reilly Christine PerretBram SnijdersJean-Paul Vincent E Yvonne Jones Molecular Metabolism Published 1 July 2021 Crick labs/ facilitiesJean-Paul VincentProteomicsFull details Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition Authors (7)Carles Recasens AlvarezCyrille AlexandreJoanna Kirkpatrick Hisashi Nojima David J HuelsBram SnijdersJean-Paul Vincent Nature Cell Biology Published 1 February 2021 Crick labs/ facilitiesJean-Paul VincentProteomicsFull details 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit Authors (18) William Mahy Nicky J Willis Yuguang Zhao Hannah L Woodward Fredrik Svensson James Sipthorp[...] Patricia C Salinas Paul WhitingJean-Paul Vincent E Yvonne Jones Paul V Fish Journal of Medicinal Chemistry Published 12 November 2020 Crick labs/ facilitiesJean-Paul VincentStructural BiologyFull details Glypicans shield the Wnt lipid moiety to enable signalling at a distance Authors (10)Ian Mcgough Luca Vecchia Benjamin Bishop Tomas Malinauskas Karen BeckettDhira JoshiNicola O'Reilly Christian Siebold E Yvonne JonesJean-Paul Vincent Nature Published 3 September 2020 Crick labsJean-Paul VincentFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level Authors (6)Gantas Perez MockusLuca CocconiCyrille AlexandreBirgit AerneGuillaume SalbreuxJean-Paul Vincent Developmental Cell Published 23 October 2023 Crick labs/ facilitiesJean-Paul VincentNic TaponGuillaume SalbreuxLight MicroscopyAdvanced SequencingFull details
Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit Authors (24) Nicky J Willis William Mahy James Sipthorp Yuguang Zhao Hannah L Woodward Benjamin N Atkinson[...] Patricia C SalinasJean-Paul Vincent E Yvonne Jones Paul Whiting Paul V Fish Journal of Medicinal Chemistry Published 26 May 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyProteomicsTranslation teamCell ServicesFull details
Notum deacylates octanoylated ghrelin Authors (11) Yuguang ZhaoLaura Nadine SchuhmacherMorgan Roberts Satoshi KakugawaGanka Bineva-Todd Steve HowellNicola O'Reilly Christine PerretBram SnijdersJean-Paul Vincent E Yvonne Jones Molecular Metabolism Published 1 July 2021 Crick labs/ facilitiesJean-Paul VincentProteomicsFull details
Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition Authors (7)Carles Recasens AlvarezCyrille AlexandreJoanna Kirkpatrick Hisashi Nojima David J HuelsBram SnijdersJean-Paul Vincent Nature Cell Biology Published 1 February 2021 Crick labs/ facilitiesJean-Paul VincentProteomicsFull details
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit Authors (18) William Mahy Nicky J Willis Yuguang Zhao Hannah L Woodward Fredrik Svensson James Sipthorp[...] Patricia C Salinas Paul WhitingJean-Paul Vincent E Yvonne Jones Paul V Fish Journal of Medicinal Chemistry Published 12 November 2020 Crick labs/ facilitiesJean-Paul VincentStructural BiologyFull details
Glypicans shield the Wnt lipid moiety to enable signalling at a distance Authors (10)Ian Mcgough Luca Vecchia Benjamin Bishop Tomas Malinauskas Karen BeckettDhira JoshiNicola O'Reilly Christian Siebold E Yvonne JonesJean-Paul Vincent Nature Published 3 September 2020 Crick labsJean-Paul VincentFull details