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Breadcrumb Jernej Ule Ule lab RNA Networks Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Genes in the brain are very long and can be transcribed into diverse RNAs. Toggle to view hero caption PublicationsYear published2023 (3)2022 (3)2021 (3)2020 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (10)Computational & Systems Biology (10)Gene Expression (10)Genetics & Genomics (10)Neurosciences (10)Stem Cells (10)Cell Biology (8)Tumour Biology (6)Genome Integrity & Repair (5)Model Organisms (5)Structural Biology & Biophysics (5)Cell Cycle & Chromosomes (4)Metabolism (4)Signalling & Oncogenes (4)Synthetic Biology (4)Developmental Biology (3)Human Biology & Physiology (3)Immunology (3)Infectious Disease (3)Imaging (1)Microfabrication & Bioengineering (1) (-)Chemical Biology & High Throughput (10) Facet Research topicsPublication typeJournal article (10)Primary research (10) Facet Publication typeJournalNature Communications (3)eLife (1)Journal of Biological Chemistry (1)Life Science Alliance (1)Molecular Cell (1)Nature (1)Neuron (1)The Lancet (1) Facet Journal Publications Displaying 1 - 10 of 10Last updated : 19 April 2024 03:12 Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides Authors (14) Rubika BalendraIgor Ruiz De Los Mozos Hana M Odeh Idoia Glaria Carmelo Milioto Katherine M Wilson[...] Stephen MartinRickie Patani James ShorterJernej Ule Adrian M Isaacs Life Science Alliance Published 1 September 2023 Crick labs/ facilitiesJernej UleRickie PataniStructural BiologyHigh Throughput ScreeningFull details Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Authors (10)Oliver ZiffJasmine HarleyYiran WangJacob NeevesGiulia Tyzack Fairouz IbrahimMark SkehelAnob ChakrabartiGavin KellyRickie Patani Neuron Published 4 October 2023 Crick labs/ facilitiesJernej UleRickie PataniProteomicsBioinformatics and BiostatisticsFull details Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast Authors (18) Radhika A VarierTheodora SideriCharlotte CapitanchikZornitsa ManovaEnrica CalvaniAlice Rossi[...] Michiel VermeulenMarkus RalserJernej UleNicholas LuscombeFolkert Van Werven eLife Published 24 November 2022 Crick labs/ facilitiesFolkert van WervenJernej UleMarkus RalserNicholas LuscombeProteomicsMetabolomicsBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A Authors (32) Anna-Leigh BrownOscar Wilkins Matthew J Keuss Sarah E Hill Matteo Zanovello Weaverly Colleen Lee[...]Jernej Ule Emanuele Buratti Jack Humphrey Michael E Ward Pietro Fratta Nature Published 3 March 2022 Crick labs/ facilitiesJernej UleStructural BiologyFull details A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division Authors (12)Silvia MartiniKhalil DavisRupert Faraway Lisa ElzeNicola LockwoodAndrew Jones[...]Neil McDonald David J Mann Alan ArmstrongJernej UlePeter Parker Nature Communications Published 26 November 2021 Crick labs/ facilitiesJernej UlePeter ParkerPaul NurseNeil McDonaldProteomicsLight MicroscopyFull details Metabolic turnover and dynamics of modified ribonucleosides by 13C labeling Authors (5)Paulo Gameiro Vesela EnchevaMariana Silva Dos SantosJames MacraeJernej Ule Journal of Biological Chemistry Published 1 November 2021 Crick labs/ facilitiesJernej UleProteomicsMetabolomicsFull details Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin Authors (17) Lenka Skalska Victoria Begley Manuel Beltran Saulius Lukauskas Garima KhandelwalPeter Faull[...] Javier Herrero Silvia SurinovaBram Snijders Till Bartke Richard G Jenner Molecular Cell Published 15 July 2021 Crick labs/ facilitiesJernej UleProteomicsFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides Authors (14) Rubika BalendraIgor Ruiz De Los Mozos Hana M Odeh Idoia Glaria Carmelo Milioto Katherine M Wilson[...] Stephen MartinRickie Patani James ShorterJernej Ule Adrian M Isaacs Life Science Alliance Published 1 September 2023 Crick labs/ facilitiesJernej UleRickie PataniStructural BiologyHigh Throughput ScreeningFull details
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Authors (10)Oliver ZiffJasmine HarleyYiran WangJacob NeevesGiulia Tyzack Fairouz IbrahimMark SkehelAnob ChakrabartiGavin KellyRickie Patani Neuron Published 4 October 2023 Crick labs/ facilitiesJernej UleRickie PataniProteomicsBioinformatics and BiostatisticsFull details
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details
N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast Authors (18) Radhika A VarierTheodora SideriCharlotte CapitanchikZornitsa ManovaEnrica CalvaniAlice Rossi[...] Michiel VermeulenMarkus RalserJernej UleNicholas LuscombeFolkert Van Werven eLife Published 24 November 2022 Crick labs/ facilitiesFolkert van WervenJernej UleMarkus RalserNicholas LuscombeProteomicsMetabolomicsBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details
Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A Authors (32) Anna-Leigh BrownOscar Wilkins Matthew J Keuss Sarah E Hill Matteo Zanovello Weaverly Colleen Lee[...]Jernej Ule Emanuele Buratti Jack Humphrey Michael E Ward Pietro Fratta Nature Published 3 March 2022 Crick labs/ facilitiesJernej UleStructural BiologyFull details
A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division Authors (12)Silvia MartiniKhalil DavisRupert Faraway Lisa ElzeNicola LockwoodAndrew Jones[...]Neil McDonald David J Mann Alan ArmstrongJernej UlePeter Parker Nature Communications Published 26 November 2021 Crick labs/ facilitiesJernej UlePeter ParkerPaul NurseNeil McDonaldProteomicsLight MicroscopyFull details
Metabolic turnover and dynamics of modified ribonucleosides by 13C labeling Authors (5)Paulo Gameiro Vesela EnchevaMariana Silva Dos SantosJames MacraeJernej Ule Journal of Biological Chemistry Published 1 November 2021 Crick labs/ facilitiesJernej UleProteomicsMetabolomicsFull details
Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin Authors (17) Lenka Skalska Victoria Begley Manuel Beltran Saulius Lukauskas Garima KhandelwalPeter Faull[...] Javier Herrero Silvia SurinovaBram Snijders Till Bartke Richard G Jenner Molecular Cell Published 15 July 2021 Crick labs/ facilitiesJernej UleProteomicsFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
