Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Svejstrup lab Mechanisms of Transcription Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members A structural model of elongating RNA polymerase II (cyan) in the act of transcribing a gene. The DNA strands are yellow and green, respectively, while the newly synthesized RNA is red. Toggle to view hero caption PublicationsYear published2023 (1)2022 (5)2021 (4)2020 (6)2019 (4)2017 (2)2016 (4)2015 (2)2014 (2)2013 (2)2012 (4)2011 (2)2010 (5) Facet Year publishedResearch topicsBiochemistry & Proteomics (28)Gene Expression (28)Genetics & Genomics (28)Genome Integrity & Repair (28)Model Organisms (28)Computational & Systems Biology (23)Chemical Biology & High Throughput (22)Tumour Biology (22)Signalling & Oncogenes (2)Structural Biology & Biophysics (2)Human Biology & Physiology (1) Facet Research topicsPublication typeJournal article (43) (-)Primary research (43) Facet Publication typeJournalMolecular Cell (9)Cell (7)Cell Reports (3)Journal of Biological Chemistry (3)Molecular and Cellular Biology (3)DNA Repair (2)Nature (2)PLOS ONE (2)Science advances (2)Cell Reports Methods (1)Genes & Development (1)Genetics (1)Genome Research (1)Journal of Genetics and Genomics (1)Nature Cell Biology (1)Nucleic Acids Research (1)Oncogene (1)Proceedings of the National Academy of Sciences of the United States of America (1)Structure (1) Facet Journal Publications Displaying 1 - 20 of 43Last updated : 28 March 2024 03:02 DNA-directed termination of RNA polymerase II transcription Authors (8) Zhong Han George A Moore Richard Mitter David Lopez MartinezLi Wan A Barbara Dirac Svejstrup David S RuedaJesper Svejstrup Molecular Cell Published 21 September 2023 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details Elongation factor-specific capture of RNA polymerase II complexes Authors (3) Lea H Gregersen Richard MitterJesper Svejstrup Cell Reports Methods Published 19 December 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsAdvanced SequencingFull details Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress Authors (9)Michelle LehnerJane Walker Kotryna TemcinaiteAnna Herlihy Michael Taschner Adam C Berger Anita H Corbett A Barbara Dirac SvejstrupJesper Svejstrup Cell Reports Published 25 October 2022 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesBioinformatics and BiostatisticsFull details An important role for RPRD1B in the heat shock response Authors (6) Simona CugusiPrashanth Bajpe Richard Mitter Harshil PatelAengus StewartJesper Svejstrup Molecular and Cellular Biology Published 1 October 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1 Authors (9)Anna Herlihy Stefan Boeing Juston C WeemsJane WalkerBarbara Dirac-SvejstrupMichelle Lehner Ronald C Conaway Joan W ConawayJesper Svejstrup DNA Repair Published 1 July 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details Heat shock induces premature transcript termination and reconfigures the human transcriptome Authors (9) Simona Cugusi Richard MitterGavin KellyJane Walker Zhong Han Paola Pisano Michael WiererAengus StewartJesper Svejstrup Molecular Cell Published 21 April 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsCell ServicesAdvanced SequencingFull details Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage Authors (14) Elisabetta Morini Dadi Gao Emily M Logan Monica Salani Aram J Krauson Anil Chekuri[...] Serkan Erdin Alexei StortchevoiJesper Svejstrup Michael E Talkowski Susan A Slaugenhaupt Journal of Genetics and Genomics Published 1 July 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response Authors (13) Lee Mulderrig Juan I Garaycoechea Zewen K Tuong Christopher L Millington Felix A Dingler John R Ferdinand[...] Mark J Arends Stephen O'Rahilly Gerry P Crossan Menna R Clatworthy Ketan J Patel Nature Published 2 December 2021 Crick labsJesper SvejstrupFull details Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability Authors (31) Marit E Geijer Di Zhou Kathiresan Selvam Barbara Steurer Chirantani Mukherjee Bastiaan Evers[...] René BernardsJesper Svejstrup Arnab Ray Chaudhuri John J Wyrick Jurgen A Marteijn Nature Cell Biology Published 1 June 2021 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsAdvanced SequencingFull details Translation stress and collided ribosomes are co-activators of cGAS Authors (11)Li Wan Szymon Juszkiewicz Daniel Blears Prashanth Kumar Bajpe Zhong HanPeter Faull Richard MitterAengus StewartBram Snijders Ramanujan S HegdeJesper Svejstrup Molecular Cell Published 1 July 2021 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryCell ServicesAdvanced SequencingFull details The ASC-1 complex disassembles collided ribosomes Authors (5) Szymon JuszkiewiczShaun SpeldewindeLi WanJesper Svejstrup Ramanujan S Hegde Molecular Cell Published 20 August 2020 Crick labs/ facilitiesJesper SvejstrupStructural BiologyFull details Evidence that STK19 is not an NRAS-dependent melanoma driver Authors (11)Marta Rodriguez Martinez Thierry BoissiéreMelvin Noe GonzalezKevin Litchfield Richard MitterJane WalkerSvend KjaerSoly IsmailJulian DownwardCharles SwantonJesper Svejstrup Cell Published 11 June 2020 Crick labs/ facilitiesCharles SwantonJesper SvejstrupJulian DownwardStructural BiologyBioinformatics and BiostatisticsProteomicsCell ServicesFull details DDI2 Is a ubiquitin-directed endoprotease responsible for cleavage of transcription factor NRF1 Authors (13)Barbara Dirac-SvejstrupJane WalkerPeter Faull Vesela Encheva Vyacheslav Akimov Michele Puglia[...] Suchete S Hunjan Blagoy BlagoevBram Snijders David J PowellJesper Svejstrup Molecular Cell Published 16 July 2020 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesFull details CDK13 cooperates with CDK12 to control global RNA polymerase II processivity Authors (21) Z Fan JR Devlin SJ Hogg MA Doyle PF Harrison I Todorovski[...]Jesper Svejstrup M Geyer NS Gray SJ Vervoort RW Johnstone Science advances Published 29 April 2020 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details CDK13 cooperates with CDK12 to control global RNA polymerase II processivity Authors (21) Zheng Fan Jennifer R Devlin Simon J Hogg Maria A Doyle Paul F Harrison Izabela Todorovski[...]Jesper Svejstrup Matthias Geyer Nathanael S Gray Stephin J Vervoort Ricky W Johnstone Science advances Published 29 April 2020 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details Regulation of the RNAPII pool is integral to the DNA damage response Authors (18) Ana Tufegdžić Vidaković Richard MitterGavin KellyMichelle Neumann Michelle HarremanMarta Rodriguez Martinez[...] Ronald C Conaway Joan W ConawayBram SnijdersAengus StewartJesper Svejstrup Cell Published 19 March 2020 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsHigh Throughput ScreeningCell ServicesAdvanced SequencingFull details Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability Authors (11) Diana Zatreanu Zhong Han Richard Mitter Emanuela Tumini Hannah WilliamsLea GregersenBarbara Dirac-Svejstrup Stefania RomaAengus Stewart Andres AguileraJesper Svejstrup Molecular Cell Published 3 October 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsHigh Throughput ScreeningAdvanced SequencingFull details A ubiquitin-binding domain that binds a structural fold distinct from that of ubiquitin Authors (8) Michael Lim Joseph A Newman Hannah L WilliamsLaura Masino Hazel Aitkenhead Angeline E Gravard Opher GileadiJesper Svejstrup Structure Published 6 August 2019 Crick labs/ facilitiesJesper SvejstrupStructural BiologyProteomicsCell ServicesFull details Genome-wide reconstitution of chromatin transactions reveals that RSC preferentially disrupts H2AZ-containing nucleosomes Authors (7)Aylin Cakiroglu Cedric R Clapier Andreas H Ehrensberger Elodie Darbo Bradley R CairnsNicholas LuscombeJesper Svejstrup Genome Research Published 1 June 2019 Crick labs/ facilitiesJesper SvejstrupNicholas LuscombeAdvanced SequencingFull details SCAF4 and SCAF8, mRNA anti-terminator proteins Authors (8)Lea Gregersen Richard Mitter Alejandro P Ugalde Takayuki Nojima Nicholas J Proudfoot Reuven AgamiAengus StewartJesper Svejstrup Cell Published 13 June 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
DNA-directed termination of RNA polymerase II transcription Authors (8) Zhong Han George A Moore Richard Mitter David Lopez MartinezLi Wan A Barbara Dirac Svejstrup David S RuedaJesper Svejstrup Molecular Cell Published 21 September 2023 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details
Elongation factor-specific capture of RNA polymerase II complexes Authors (3) Lea H Gregersen Richard MitterJesper Svejstrup Cell Reports Methods Published 19 December 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsAdvanced SequencingFull details
Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress Authors (9)Michelle LehnerJane Walker Kotryna TemcinaiteAnna Herlihy Michael Taschner Adam C Berger Anita H Corbett A Barbara Dirac SvejstrupJesper Svejstrup Cell Reports Published 25 October 2022 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesBioinformatics and BiostatisticsFull details
An important role for RPRD1B in the heat shock response Authors (6) Simona CugusiPrashanth Bajpe Richard Mitter Harshil PatelAengus StewartJesper Svejstrup Molecular and Cellular Biology Published 1 October 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1 Authors (9)Anna Herlihy Stefan Boeing Juston C WeemsJane WalkerBarbara Dirac-SvejstrupMichelle Lehner Ronald C Conaway Joan W ConawayJesper Svejstrup DNA Repair Published 1 July 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details
Heat shock induces premature transcript termination and reconfigures the human transcriptome Authors (9) Simona Cugusi Richard MitterGavin KellyJane Walker Zhong Han Paola Pisano Michael WiererAengus StewartJesper Svejstrup Molecular Cell Published 21 April 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsCell ServicesAdvanced SequencingFull details
Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage Authors (14) Elisabetta Morini Dadi Gao Emily M Logan Monica Salani Aram J Krauson Anil Chekuri[...] Serkan Erdin Alexei StortchevoiJesper Svejstrup Michael E Talkowski Susan A Slaugenhaupt Journal of Genetics and Genomics Published 1 July 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response Authors (13) Lee Mulderrig Juan I Garaycoechea Zewen K Tuong Christopher L Millington Felix A Dingler John R Ferdinand[...] Mark J Arends Stephen O'Rahilly Gerry P Crossan Menna R Clatworthy Ketan J Patel Nature Published 2 December 2021 Crick labsJesper SvejstrupFull details
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability Authors (31) Marit E Geijer Di Zhou Kathiresan Selvam Barbara Steurer Chirantani Mukherjee Bastiaan Evers[...] René BernardsJesper Svejstrup Arnab Ray Chaudhuri John J Wyrick Jurgen A Marteijn Nature Cell Biology Published 1 June 2021 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsAdvanced SequencingFull details
Translation stress and collided ribosomes are co-activators of cGAS Authors (11)Li Wan Szymon Juszkiewicz Daniel Blears Prashanth Kumar Bajpe Zhong HanPeter Faull Richard MitterAengus StewartBram Snijders Ramanujan S HegdeJesper Svejstrup Molecular Cell Published 1 July 2021 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryCell ServicesAdvanced SequencingFull details
The ASC-1 complex disassembles collided ribosomes Authors (5) Szymon JuszkiewiczShaun SpeldewindeLi WanJesper Svejstrup Ramanujan S Hegde Molecular Cell Published 20 August 2020 Crick labs/ facilitiesJesper SvejstrupStructural BiologyFull details
Evidence that STK19 is not an NRAS-dependent melanoma driver Authors (11)Marta Rodriguez Martinez Thierry BoissiéreMelvin Noe GonzalezKevin Litchfield Richard MitterJane WalkerSvend KjaerSoly IsmailJulian DownwardCharles SwantonJesper Svejstrup Cell Published 11 June 2020 Crick labs/ facilitiesCharles SwantonJesper SvejstrupJulian DownwardStructural BiologyBioinformatics and BiostatisticsProteomicsCell ServicesFull details
DDI2 Is a ubiquitin-directed endoprotease responsible for cleavage of transcription factor NRF1 Authors (13)Barbara Dirac-SvejstrupJane WalkerPeter Faull Vesela Encheva Vyacheslav Akimov Michele Puglia[...] Suchete S Hunjan Blagoy BlagoevBram Snijders David J PowellJesper Svejstrup Molecular Cell Published 16 July 2020 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesFull details
CDK13 cooperates with CDK12 to control global RNA polymerase II processivity Authors (21) Z Fan JR Devlin SJ Hogg MA Doyle PF Harrison I Todorovski[...]Jesper Svejstrup M Geyer NS Gray SJ Vervoort RW Johnstone Science advances Published 29 April 2020 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details
CDK13 cooperates with CDK12 to control global RNA polymerase II processivity Authors (21) Zheng Fan Jennifer R Devlin Simon J Hogg Maria A Doyle Paul F Harrison Izabela Todorovski[...]Jesper Svejstrup Matthias Geyer Nathanael S Gray Stephin J Vervoort Ricky W Johnstone Science advances Published 29 April 2020 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details
Regulation of the RNAPII pool is integral to the DNA damage response Authors (18) Ana Tufegdžić Vidaković Richard MitterGavin KellyMichelle Neumann Michelle HarremanMarta Rodriguez Martinez[...] Ronald C Conaway Joan W ConawayBram SnijdersAengus StewartJesper Svejstrup Cell Published 19 March 2020 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsHigh Throughput ScreeningCell ServicesAdvanced SequencingFull details
Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability Authors (11) Diana Zatreanu Zhong Han Richard Mitter Emanuela Tumini Hannah WilliamsLea GregersenBarbara Dirac-Svejstrup Stefania RomaAengus Stewart Andres AguileraJesper Svejstrup Molecular Cell Published 3 October 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsHigh Throughput ScreeningAdvanced SequencingFull details
A ubiquitin-binding domain that binds a structural fold distinct from that of ubiquitin Authors (8) Michael Lim Joseph A Newman Hannah L WilliamsLaura Masino Hazel Aitkenhead Angeline E Gravard Opher GileadiJesper Svejstrup Structure Published 6 August 2019 Crick labs/ facilitiesJesper SvejstrupStructural BiologyProteomicsCell ServicesFull details
Genome-wide reconstitution of chromatin transactions reveals that RSC preferentially disrupts H2AZ-containing nucleosomes Authors (7)Aylin Cakiroglu Cedric R Clapier Andreas H Ehrensberger Elodie Darbo Bradley R CairnsNicholas LuscombeJesper Svejstrup Genome Research Published 1 June 2019 Crick labs/ facilitiesJesper SvejstrupNicholas LuscombeAdvanced SequencingFull details
SCAF4 and SCAF8, mRNA anti-terminator proteins Authors (8)Lea Gregersen Richard Mitter Alejandro P Ugalde Takayuki Nojima Nicholas J Proudfoot Reuven AgamiAengus StewartJesper Svejstrup Cell Published 13 June 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details