Publications

DNA-directed termination of RNA polymerase II transcription

Authors (8)

Zhong Han
George A Moore
Richard Mitter
David Lopez Martinez
Li Wan
A Barbara Dirac Svejstrup
David S Rueda
Jesper Svejstrup

Molecular Cell

Published 21 September 2023

Crick labs/ facilities

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Elongation factor-specific capture of RNA polymerase II complexes

Authors (3)

Lea H Gregersen
Richard Mitter
Jesper Svejstrup

Cell Reports Methods

Published 19 December 2022

Crick labs/ facilities

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An important role for RPRD1B in the heat shock response

Authors (6)

Simona Cugusi
Prashanth Bajpe
Richard Mitter
Harshil Patel
Aengus Stewart
Jesper Svejstrup

Molecular and Cellular Biology

Published 1 October 2022

Crick labs/ facilities

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UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1

Authors (9)

Anna Herlihy
Stefan Boeing
Juston C Weems
Jane Walker
Barbara Dirac-Svejstrup
Michelle Lehner
Ronald C Conaway
Joan W Conaway
Jesper Svejstrup

DNA Repair

Published 1 July 2022

Crick labs/ facilities

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Heat shock induces premature transcript termination and reconfigures the human transcriptome

Authors (9)

Simona Cugusi
Richard Mitter
Gavin Kelly
Jane Walker
Zhong Han
Paola Pisano
Michael Wierer
Aengus Stewart
Jesper Svejstrup

Molecular Cell

Published 21 April 2022

Crick labs/ facilities

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Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage

Authors (14)

Elisabetta Morini
Dadi Gao
Emily M Logan
Monica Salani
Aram J Krauson
Anil Chekuri
[...]
Serkan Erdin
Alexei Stortchevoi
Jesper Svejstrup
Michael E Talkowski
Susan A Slaugenhaupt

Journal of Genetics and Genomics

Published 1 July 2022

Crick labs/ facilities

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Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

Authors (31)

Marit E Geijer
Di Zhou
Kathiresan Selvam
Barbara Steurer
Chirantani Mukherjee
Bastiaan Evers
[...]
René Bernards
Jesper Svejstrup
Arnab Ray Chaudhuri
John J Wyrick
Jurgen A Marteijn

Nature Cell Biology

Published 1 June 2021

Crick labs/ facilities

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Translation stress and collided ribosomes are co-activators of cGAS

Authors (11)

Li Wan
Szymon Juszkiewicz
Daniel Blears
Prashanth Kumar Bajpe
Zhong Han
Peter Faull
Richard Mitter
Aengus Stewart
Bram Snijders
Ramanujan S Hegde
Jesper Svejstrup

Molecular Cell

Published 1 July 2021

Crick labs/ facilities

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Evidence that STK19 is not an NRAS-dependent melanoma driver

Authors (11)

Cell

Published 11 June 2020

Crick labs/ facilities

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DDI2 Is a ubiquitin-directed endoprotease responsible for cleavage of transcription factor NRF1

Authors (13)

Barbara Dirac-Svejstrup
Jane Walker
Peter Faull
Vesela Encheva
Vyacheslav Akimov
Michele Puglia
[...]
Suchete S Hunjan
Blagoy Blagoev
Bram Snijders
David J Powell
Jesper Svejstrup

Molecular Cell

Published 16 July 2020

Crick labs/ facilities

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CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Authors (21)

Zheng Fan
Jennifer R Devlin
Simon J Hogg
Maria A Doyle
Paul F Harrison
Izabela Todorovski
[...]
Jesper Svejstrup
Matthias Geyer
Nathanael S Gray
Stephin J Vervoort
Ricky W Johnstone

Science advances

Published 29 April 2020

Crick labs/ facilities

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CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Authors (21)

Z Fan
JR Devlin
SJ Hogg
MA Doyle
PF Harrison
I Todorovski
[...]
Jesper Svejstrup
M Geyer
NS Gray
SJ Vervoort
RW Johnstone

Science advances

Published 29 April 2020

Crick labs/ facilities

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Regulation of the RNAPII pool is integral to the DNA damage response

Authors (18)

Ana Tufegdžić Vidaković
Richard Mitter
Gavin Kelly
Michelle Neumann
Michelle Harreman
Marta Rodriguez Martinez
[...]
Ronald C Conaway
Joan W Conaway
Bram Snijders
Aengus Stewart
Jesper Svejstrup

Cell

Published 19 March 2020

Crick labs/ facilities

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Using TTchem-seq for profiling nascent transcription and measuring transcript elongation

Authors (3)

Nature Protocols

Published 1 February 2020

Crick labs/ facilities

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Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability

Authors (11)

Diana Zatreanu
Zhong Han
Richard Mitter
Emanuela Tumini
Hannah Williams
Lea Gregersen
Barbara Dirac-Svejstrup
Stefania Roma
Aengus Stewart
Andres Aguilera
Jesper Svejstrup

Molecular Cell

Published 3 October 2019

Crick labs/ facilities

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SCAF4 and SCAF8, mRNA anti-terminator proteins

Authors (8)

Lea Gregersen
Richard Mitter
Alejandro P Ugalde
Takayuki Nojima
Nicholas J Proudfoot
Reuven Agami
Aengus Stewart
Jesper Svejstrup

Cell

Published 13 June 2019

Crick labs/ facilities

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Analysis of RNA polymerase II ubiquitylation and proteasomal degradation

Authors (10)

Methods

Published 15 April 2019

Crick labs/ facilities

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UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene

Authors (13)

Laura Williamson
Marco Saponaro
Stefan Boeing
Phil East
Richard Mitter
Theodoros Kantidakis
[...]
Jane Walker
Bradley Spencer-Dene
Michael Howell
Aengus Stewart
Jesper Svejstrup

Cell

Published 23 February 2017

Crick labs/ facilities

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Multiomic analysis of the UV-induced DNA damage response

Authors (16)

Stefan Boeing
Laura Williamson
Vesela Encheva
Ilaria Gori
Rebecca E Saunders
Rachael Instrell
[...]
Ronald C Conaway
Aengus Stewart
Michael Howell
Bram Snijders
Jesper Svejstrup

Cell Reports

Published 17 May 2016

Crick labs/ facilities

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A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair

Authors (14)

Michael Ranes
Stefan Boeing
Yuming Wang
Franziska Wienholz
Hervé Menoni
Jane Walker
[...]
Aengus Stewart
Giuseppina Giglia-Mari
Bram Snijders
Wim Vermeulen
Jesper Svejstrup

Nucleic Acids Research

Published 20 June 2016

Crick labs/ facilities

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Mechanisms of Transcription Laboratory
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DNA-directed termination of RNA polymerase II transcription

Elongation factor-specific capture of RNA polymerase II complexes

An important role for RPRD1B in the heat shock response

UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1

Heat shock induces premature transcript termination and reconfigures the human transcriptome

Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage

Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

Translation stress and collided ribosomes are co-activators of cGAS

Evidence that STK19 is not an NRAS-dependent melanoma driver

DDI2 Is a ubiquitin-directed endoprotease responsible for cleavage of transcription factor NRF1

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Regulation of the RNAPII pool is integral to the DNA damage response

Using TTchem-seq for profiling nascent transcription and measuring transcript elongation

Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability

SCAF4 and SCAF8, mRNA anti-terminator proteins

Analysis of RNA polymerase II ubiquitylation and proteasomal degradation

UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene

Multiomic analysis of the UV-induced DNA damage response

A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair

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