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Svejstrup lab Mechanisms of Transcription Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members A structural model of elongating RNA polymerase II (cyan) in the act of transcribing a gene. The DNA strands are yellow and green, respectively, while the newly synthesized RNA is red. Toggle to view hero caption PublicationsYear published2023 (1)2022 (4)2021 (3)2020 (6)2019 (4)2017 (1)2016 (4)2015 (2) Facet Year publishedResearch topicsBiochemistry & Proteomics (25)Gene Expression (25)Genetics & Genomics (25)Genome Integrity & Repair (25)Model Organisms (25)Chemical Biology & High Throughput (24)Tumour Biology (23)Signalling & Oncogenes (2)Structural Biology & Biophysics (2)Human Biology & Physiology (1) (-)Computational & Systems Biology (25) Facet Research topicsPublication typeJournal article (25)Primary research (23)Method (2) Facet Publication typeJournalMolecular Cell (5)Cell (4)Cell Reports (2)Science advances (2)Cell Reports Methods (1)DNA Repair (1)Genes & Development (1)Genome Research (1)Journal of Genetics and Genomics (1)Methods (1)Molecular and Cellular Biology (1)Nature Cell Biology (1)Nature Protocols (1)Nucleic Acids Research (1)Oncogene (1)PLOS ONE (1) Facet Journal Publications Displaying 1 - 20 of 25Last updated : 29 March 2024 03:35 DNA-directed termination of RNA polymerase II transcription Authors (8) Zhong Han George A Moore Richard Mitter David Lopez MartinezLi Wan A Barbara Dirac Svejstrup David S RuedaJesper Svejstrup Molecular Cell Published 21 September 2023 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details Elongation factor-specific capture of RNA polymerase II complexes Authors (3) Lea H Gregersen Richard MitterJesper Svejstrup Cell Reports Methods Published 19 December 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsAdvanced SequencingFull details An important role for RPRD1B in the heat shock response Authors (6) Simona CugusiPrashanth Bajpe Richard Mitter Harshil PatelAengus StewartJesper Svejstrup Molecular and Cellular Biology Published 1 October 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1 Authors (9)Anna Herlihy Stefan Boeing Juston C WeemsJane WalkerBarbara Dirac-SvejstrupMichelle Lehner Ronald C Conaway Joan W ConawayJesper Svejstrup DNA Repair Published 1 July 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details Heat shock induces premature transcript termination and reconfigures the human transcriptome Authors (9) Simona Cugusi Richard MitterGavin KellyJane Walker Zhong Han Paola Pisano Michael WiererAengus StewartJesper Svejstrup Molecular Cell Published 21 April 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsCell ServicesAdvanced SequencingFull details Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage Authors (14) Elisabetta Morini Dadi Gao Emily M Logan Monica Salani Aram J Krauson Anil Chekuri[...] Serkan Erdin Alexei StortchevoiJesper Svejstrup Michael E Talkowski Susan A Slaugenhaupt Journal of Genetics and Genomics Published 1 July 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability Authors (31) Marit E Geijer Di Zhou Kathiresan Selvam Barbara Steurer Chirantani Mukherjee Bastiaan Evers[...] René BernardsJesper Svejstrup Arnab Ray Chaudhuri John J Wyrick Jurgen A Marteijn Nature Cell Biology Published 1 June 2021 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsAdvanced SequencingFull details Translation stress and collided ribosomes are co-activators of cGAS Authors (11)Li Wan Szymon Juszkiewicz Daniel Blears Prashanth Kumar Bajpe Zhong HanPeter Faull Richard MitterAengus StewartBram Snijders Ramanujan S HegdeJesper Svejstrup Molecular Cell Published 1 July 2021 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryCell ServicesAdvanced SequencingFull details Evidence that STK19 is not an NRAS-dependent melanoma driver Authors (11)Marta Rodriguez Martinez Thierry BoissiéreMelvin Noe GonzalezKevin Litchfield Richard MitterJane WalkerSvend KjaerSoly IsmailJulian DownwardCharles SwantonJesper Svejstrup Cell Published 11 June 2020 Crick labs/ facilitiesCharles SwantonJesper SvejstrupJulian DownwardStructural BiologyBioinformatics and BiostatisticsProteomicsCell ServicesFull details DDI2 Is a ubiquitin-directed endoprotease responsible for cleavage of transcription factor NRF1 Authors (13)Barbara Dirac-SvejstrupJane WalkerPeter Faull Vesela Encheva Vyacheslav Akimov Michele Puglia[...] Suchete S Hunjan Blagoy BlagoevBram Snijders David J PowellJesper Svejstrup Molecular Cell Published 16 July 2020 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesFull details CDK13 cooperates with CDK12 to control global RNA polymerase II processivity Authors (21) Z Fan JR Devlin SJ Hogg MA Doyle PF Harrison I Todorovski[...]Jesper Svejstrup M Geyer NS Gray SJ Vervoort RW Johnstone Science advances Published 29 April 2020 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details CDK13 cooperates with CDK12 to control global RNA polymerase II processivity Authors (21) Zheng Fan Jennifer R Devlin Simon J Hogg Maria A Doyle Paul F Harrison Izabela Todorovski[...]Jesper Svejstrup Matthias Geyer Nathanael S Gray Stephin J Vervoort Ricky W Johnstone Science advances Published 29 April 2020 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details Regulation of the RNAPII pool is integral to the DNA damage response Authors (18) Ana Tufegdžić Vidaković Richard MitterGavin KellyMichelle Neumann Michelle HarremanMarta Rodriguez Martinez[...] Ronald C Conaway Joan W ConawayBram SnijdersAengus StewartJesper Svejstrup Cell Published 19 March 2020 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsHigh Throughput ScreeningCell ServicesAdvanced SequencingFull details Using TTchem-seq for profiling nascent transcription and measuring transcript elongation Authors (3)Lea Gregersen Richard MitterJesper Svejstrup Nature Protocols Published 1 February 2020 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability Authors (11) Diana Zatreanu Zhong Han Richard Mitter Emanuela Tumini Hannah WilliamsLea GregersenBarbara Dirac-Svejstrup Stefania RomaAengus Stewart Andres AguileraJesper Svejstrup Molecular Cell Published 3 October 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsHigh Throughput ScreeningAdvanced SequencingFull details Genome-wide reconstitution of chromatin transactions reveals that RSC preferentially disrupts H2AZ-containing nucleosomes Authors (7)Aylin Cakiroglu Cedric R Clapier Andreas H Ehrensberger Elodie Darbo Bradley R CairnsNicholas LuscombeJesper Svejstrup Genome Research Published 1 June 2019 Crick labs/ facilitiesJesper SvejstrupNicholas LuscombeAdvanced SequencingFull details SCAF4 and SCAF8, mRNA anti-terminator proteins Authors (8)Lea Gregersen Richard Mitter Alejandro P Ugalde Takayuki Nojima Nicholas J Proudfoot Reuven AgamiAengus StewartJesper Svejstrup Cell Published 13 June 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details Analysis of RNA polymerase II ubiquitylation and proteasomal degradation Authors (10)Ana Tufegdzic Vidakovic Michelle HarremanBarbara Dirac-Svejstrup Stefan Boeing Anindya Roy Vesela EnchevaMichelle Neumann Marcus WilsonBram SnijdersJesper Svejstrup Methods Published 15 April 2019 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsFull details UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene Authors (13) Laura Williamson Marco SaponaroStefan BoeingPhil East Richard Mitter Theodoros Kantidakis[...]Jane Walker Bradley Spencer-DeneMichael HowellAengus StewartJesper Svejstrup Cell Published 23 February 2017 Crick labs/ facilitiesJesper SvejstrupHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsCell ServicesAdvanced SequencingFull details Multiomic analysis of the UV-induced DNA damage response Authors (16) Stefan Boeing Laura Williamson Vesela EnchevaIlaria Gori Rebecca E SaundersRachael Instrell[...] Ronald C ConawayAengus StewartMichael HowellBram SnijdersJesper Svejstrup Cell Reports Published 17 May 2016 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsCell ServicesFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
DNA-directed termination of RNA polymerase II transcription Authors (8) Zhong Han George A Moore Richard Mitter David Lopez MartinezLi Wan A Barbara Dirac Svejstrup David S RuedaJesper Svejstrup Molecular Cell Published 21 September 2023 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details
Elongation factor-specific capture of RNA polymerase II complexes Authors (3) Lea H Gregersen Richard MitterJesper Svejstrup Cell Reports Methods Published 19 December 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsAdvanced SequencingFull details
An important role for RPRD1B in the heat shock response Authors (6) Simona CugusiPrashanth Bajpe Richard Mitter Harshil PatelAengus StewartJesper Svejstrup Molecular and Cellular Biology Published 1 October 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1 Authors (9)Anna Herlihy Stefan Boeing Juston C WeemsJane WalkerBarbara Dirac-SvejstrupMichelle Lehner Ronald C Conaway Joan W ConawayJesper Svejstrup DNA Repair Published 1 July 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details
Heat shock induces premature transcript termination and reconfigures the human transcriptome Authors (9) Simona Cugusi Richard MitterGavin KellyJane Walker Zhong Han Paola Pisano Michael WiererAengus StewartJesper Svejstrup Molecular Cell Published 21 April 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsCell ServicesAdvanced SequencingFull details
Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage Authors (14) Elisabetta Morini Dadi Gao Emily M Logan Monica Salani Aram J Krauson Anil Chekuri[...] Serkan Erdin Alexei StortchevoiJesper Svejstrup Michael E Talkowski Susan A Slaugenhaupt Journal of Genetics and Genomics Published 1 July 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability Authors (31) Marit E Geijer Di Zhou Kathiresan Selvam Barbara Steurer Chirantani Mukherjee Bastiaan Evers[...] René BernardsJesper Svejstrup Arnab Ray Chaudhuri John J Wyrick Jurgen A Marteijn Nature Cell Biology Published 1 June 2021 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsAdvanced SequencingFull details
Translation stress and collided ribosomes are co-activators of cGAS Authors (11)Li Wan Szymon Juszkiewicz Daniel Blears Prashanth Kumar Bajpe Zhong HanPeter Faull Richard MitterAengus StewartBram Snijders Ramanujan S HegdeJesper Svejstrup Molecular Cell Published 1 July 2021 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryCell ServicesAdvanced SequencingFull details
Evidence that STK19 is not an NRAS-dependent melanoma driver Authors (11)Marta Rodriguez Martinez Thierry BoissiéreMelvin Noe GonzalezKevin Litchfield Richard MitterJane WalkerSvend KjaerSoly IsmailJulian DownwardCharles SwantonJesper Svejstrup Cell Published 11 June 2020 Crick labs/ facilitiesCharles SwantonJesper SvejstrupJulian DownwardStructural BiologyBioinformatics and BiostatisticsProteomicsCell ServicesFull details
DDI2 Is a ubiquitin-directed endoprotease responsible for cleavage of transcription factor NRF1 Authors (13)Barbara Dirac-SvejstrupJane WalkerPeter Faull Vesela Encheva Vyacheslav Akimov Michele Puglia[...] Suchete S Hunjan Blagoy BlagoevBram Snijders David J PowellJesper Svejstrup Molecular Cell Published 16 July 2020 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesFull details
CDK13 cooperates with CDK12 to control global RNA polymerase II processivity Authors (21) Z Fan JR Devlin SJ Hogg MA Doyle PF Harrison I Todorovski[...]Jesper Svejstrup M Geyer NS Gray SJ Vervoort RW Johnstone Science advances Published 29 April 2020 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details
CDK13 cooperates with CDK12 to control global RNA polymerase II processivity Authors (21) Zheng Fan Jennifer R Devlin Simon J Hogg Maria A Doyle Paul F Harrison Izabela Todorovski[...]Jesper Svejstrup Matthias Geyer Nathanael S Gray Stephin J Vervoort Ricky W Johnstone Science advances Published 29 April 2020 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details
Regulation of the RNAPII pool is integral to the DNA damage response Authors (18) Ana Tufegdžić Vidaković Richard MitterGavin KellyMichelle Neumann Michelle HarremanMarta Rodriguez Martinez[...] Ronald C Conaway Joan W ConawayBram SnijdersAengus StewartJesper Svejstrup Cell Published 19 March 2020 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsHigh Throughput ScreeningCell ServicesAdvanced SequencingFull details
Using TTchem-seq for profiling nascent transcription and measuring transcript elongation Authors (3)Lea Gregersen Richard MitterJesper Svejstrup Nature Protocols Published 1 February 2020 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details
Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability Authors (11) Diana Zatreanu Zhong Han Richard Mitter Emanuela Tumini Hannah WilliamsLea GregersenBarbara Dirac-Svejstrup Stefania RomaAengus Stewart Andres AguileraJesper Svejstrup Molecular Cell Published 3 October 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsHigh Throughput ScreeningAdvanced SequencingFull details
Genome-wide reconstitution of chromatin transactions reveals that RSC preferentially disrupts H2AZ-containing nucleosomes Authors (7)Aylin Cakiroglu Cedric R Clapier Andreas H Ehrensberger Elodie Darbo Bradley R CairnsNicholas LuscombeJesper Svejstrup Genome Research Published 1 June 2019 Crick labs/ facilitiesJesper SvejstrupNicholas LuscombeAdvanced SequencingFull details
SCAF4 and SCAF8, mRNA anti-terminator proteins Authors (8)Lea Gregersen Richard Mitter Alejandro P Ugalde Takayuki Nojima Nicholas J Proudfoot Reuven AgamiAengus StewartJesper Svejstrup Cell Published 13 June 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details
Analysis of RNA polymerase II ubiquitylation and proteasomal degradation Authors (10)Ana Tufegdzic Vidakovic Michelle HarremanBarbara Dirac-Svejstrup Stefan Boeing Anindya Roy Vesela EnchevaMichelle Neumann Marcus WilsonBram SnijdersJesper Svejstrup Methods Published 15 April 2019 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsFull details
UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene Authors (13) Laura Williamson Marco SaponaroStefan BoeingPhil East Richard Mitter Theodoros Kantidakis[...]Jane Walker Bradley Spencer-DeneMichael HowellAengus StewartJesper Svejstrup Cell Published 23 February 2017 Crick labs/ facilitiesJesper SvejstrupHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsCell ServicesAdvanced SequencingFull details
Multiomic analysis of the UV-induced DNA damage response Authors (16) Stefan Boeing Laura Williamson Vesela EnchevaIlaria Gori Rebecca E SaundersRachael Instrell[...] Ronald C ConawayAengus StewartMichael HowellBram SnijdersJesper Svejstrup Cell Reports Published 17 May 2016 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsCell ServicesFull details