We study how intricate neural circuits in the brain orchestrate behaviour.

Johannes Kohl : State-Dependent Neural Processing Laboratory

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We are investigating how the state of the body shapes information processing in the brain.

The brain coordinates behaviour through evolutionarily sculpted neural circuits. These circuits do not work in isolation. Instead how they work profoundly depends on an animal’s current physiological state, such as sleep or hunger.

Little is known about the molecular, cellular and circuit-level mechanisms by which such internal states alter neural processing in the brain. We aim to address these questions by using the mouse as a model. Mice have very robust and elaborate behaviours, and we can study their brains using a wide range of recently developed genetic tools.

We will use a multidisciplinary approach, combining cutting-edge methods in circuit neuroscience, molecular and cellular biology, and behavioral analysis to investigate how signals from the rest of the body affect the brain. Studying these mechanisms will provide us with exciting insights into brain function in both health and disease.