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Breadcrumb John Diffley Diffley lab Chromosome Replication Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members A cartoon of a section of chromatin in the nucleus with replication origins in three different states. Toggle to view hero caption PublicationsYear published2022 (1)2019 (1)2018 (1)2015 (1)2013 (1)2010 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (3)Cell Biology (3)Cell Cycle & Chromosomes (3)Genetics & Genomics (3)Genome Integrity & Repair (3)Imaging (3)Model Organisms (3)Structural Biology & Biophysics (3)Chemical Biology & High Throughput (1) Facet Research topicsPublication typeJournal article (6)Primary research (6) Facet Publication typeJournal (-)Nature (6) Facet Journal Publications Displaying 1 - 6 of 6Last updated : 28 March 2024 03:02 Mechanism of replication origin melting nucleated by CMG helicase assembly Authors (8)Jacob LewisMarta Gross Joana SousaSarah HenrikusJulia GreiweAndrea NansJohn DiffleyAlessandro Costa Nature Published 30 June 2022 Crick labs/ facilitiesJohn DiffleyAlessandro CostaStructural BiologyFermentationFull details Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM Authors (5)Thomas MillerJulia LockeJulia GreiweJohn DiffleyAlessandro Costa Nature Published 20 November 2019 Crick labs/ facilitiesJohn DiffleyAlessandro CostaStructural BiologyFermentationElectron MicroscopyFull details The mechanism of eukaryotic CMG helicase activation Authors (4) Max E Douglas Ferdos Abid AliAlessandro CostaJohn Diffley Nature Published 8 March 2018 Crick labs/ facilitiesJohn DiffleyAlessandro CostaElectron MicroscopyBioinformatics and BiostatisticsFull details Regulated eukaryotic DNA replication origin firing with purified proteins Authors (5) Joseph TP Yeeles Tom D Deegan Agnieszka JanskaAnne EarlyJohn Diffley Nature Published 26 March 2015 Crick labsJohn DiffleyFull details ATPase-dependent quality control of DNA replication origin licensing Authors (4) Jordi Frigola Dirk Remus Amina MehannaJohn Diffley Nature Published 21 March 2013 Crick labsJohn DiffleyFull details Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation Authors (2) Philip ZegermanJohn Diffley Nature Published 23 September 2010 Crick labsJohn DiffleyFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Mechanism of replication origin melting nucleated by CMG helicase assembly Authors (8)Jacob LewisMarta Gross Joana SousaSarah HenrikusJulia GreiweAndrea NansJohn DiffleyAlessandro Costa Nature Published 30 June 2022 Crick labs/ facilitiesJohn DiffleyAlessandro CostaStructural BiologyFermentationFull details
Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM Authors (5)Thomas MillerJulia LockeJulia GreiweJohn DiffleyAlessandro Costa Nature Published 20 November 2019 Crick labs/ facilitiesJohn DiffleyAlessandro CostaStructural BiologyFermentationElectron MicroscopyFull details
The mechanism of eukaryotic CMG helicase activation Authors (4) Max E Douglas Ferdos Abid AliAlessandro CostaJohn Diffley Nature Published 8 March 2018 Crick labs/ facilitiesJohn DiffleyAlessandro CostaElectron MicroscopyBioinformatics and BiostatisticsFull details
Regulated eukaryotic DNA replication origin firing with purified proteins Authors (5) Joseph TP Yeeles Tom D Deegan Agnieszka JanskaAnne EarlyJohn Diffley Nature Published 26 March 2015 Crick labsJohn DiffleyFull details
ATPase-dependent quality control of DNA replication origin licensing Authors (4) Jordi Frigola Dirk Remus Amina MehannaJohn Diffley Nature Published 21 March 2013 Crick labsJohn DiffleyFull details
Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation Authors (2) Philip ZegermanJohn Diffley Nature Published 23 September 2010 Crick labsJohn DiffleyFull details