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Breadcrumb John Diffley Diffley lab Chromosome Replication Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members A cartoon of a section of chromatin in the nucleus with replication origins in three different states. Toggle to view hero caption PublicationsYear published2023 (1)2021 (5)2019 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (7)Cell Cycle & Chromosomes (7)Genetics & Genomics (7)Genome Integrity & Repair (7)Model Organisms (7)Cell Biology (6)Chemical Biology & High Throughput (6)Structural Biology & Biophysics (6)Synthetic Biology (5)Immunology (3)Infectious Disease (3)Imaging (1)Metabolism (1)Tumour Biology (1) (-)Computational & Systems Biology (7) Facet Research topicsPublication typeJournal article (7)Primary research (7) Facet Publication typeJournalBiochemical Journal (3)Cell (1)Molecular Cell (1)Nature Structural and Molecular Biology (1)RSC Advances: an international journal to further the chemical sciences (1) Facet Journal Publications Displaying 1 - 7 of 7Last updated : 24 April 2024 03:41 A replication fork determinant for the establishment of sister chromatid cohesion Authors (5)Masashi MinaminoCeline BouchouxBerta CanalJohn DiffleyFrank Uhlmann Cell Published 16 February 2023 Crick labs/ facilitiesFrank UhlmannJohn DiffleyStructural BiologyFermentationFull details Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase Authors (9)Julia GreiweThomas MillerJulia LockeFabrizio Martino Steven HowellAnne SchreiberAndrea NansJohn DiffleyAlessandro Costa Nature Structural and Molecular Biology Published 1 January 2022 Crick labs/ facilitiesAnne SchreiberJohn DiffleyAlessandro CostaStructural BiologyProteomicsFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease Authors (22)Jennifer MilliganTheresa ZeisnerGeorge PapageorgiouDhira JoshiChristelle SoudyRachel Ulferts[...]Michael HowellRupert Beale Karim LabibNicola O'ReillyJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Authors (21)Saz BasuTiffany MakRachel UlfertsMary Wu Tom Deegan Ryo Fujisawa[...]Rupert Beale Victoria H CowlingMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques Authors (6)Dhira JoshiJennifer MilliganTheresa ZeisnerNicola O'ReillyJohn DiffleyGeorge Papageorgiou RSC Advances: an international journal to further the chemical sciences Published 8 June 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyMRC Biomedical NMR CentreFull details A role for chromatin remodeling in cohesin loading onto chromosomes Authors (5)Sofia Munoz-FelixMasashi Minamino Corella S Casas-Delucchi Harshil PatelFrank Uhlmann Molecular Cell Published 16 May 2019 Crick labs/ facilitiesFrank UhlmannJohn DiffleyBioinformatics and BiostatisticsHigh Throughput ScreeningFermentationFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
A replication fork determinant for the establishment of sister chromatid cohesion Authors (5)Masashi MinaminoCeline BouchouxBerta CanalJohn DiffleyFrank Uhlmann Cell Published 16 February 2023 Crick labs/ facilitiesFrank UhlmannJohn DiffleyStructural BiologyFermentationFull details
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase Authors (9)Julia GreiweThomas MillerJulia LockeFabrizio Martino Steven HowellAnne SchreiberAndrea NansJohn DiffleyAlessandro Costa Nature Structural and Molecular Biology Published 1 January 2022 Crick labs/ facilitiesAnne SchreiberJohn DiffleyAlessandro CostaStructural BiologyProteomicsFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease Authors (22)Jennifer MilliganTheresa ZeisnerGeorge PapageorgiouDhira JoshiChristelle SoudyRachel Ulferts[...]Michael HowellRupert Beale Karim LabibNicola O'ReillyJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Authors (21)Saz BasuTiffany MakRachel UlfertsMary Wu Tom Deegan Ryo Fujisawa[...]Rupert Beale Victoria H CowlingMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques Authors (6)Dhira JoshiJennifer MilliganTheresa ZeisnerNicola O'ReillyJohn DiffleyGeorge Papageorgiou RSC Advances: an international journal to further the chemical sciences Published 8 June 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyMRC Biomedical NMR CentreFull details
A role for chromatin remodeling in cohesin loading onto chromosomes Authors (5)Sofia Munoz-FelixMasashi Minamino Corella S Casas-Delucchi Harshil PatelFrank Uhlmann Molecular Cell Published 16 May 2019 Crick labs/ facilitiesFrank UhlmannJohn DiffleyBioinformatics and BiostatisticsHigh Throughput ScreeningFermentationFull details