Diffley lab
Chromosome Replication Laboratory
: Publications

Publications

Displaying 1 - 9 of 9

Last updated : 20 April 2024 03:27

Mechanism of replication origin melting nucleated by CMG helicase assembly

Authors (8)

Nature

Published 30 June 2022

Crick labs/ facilities

Full details

The initiation of eukaryotic DNA replication

Authors (2)

Annual Review of Biochemistry

Published 1 June 2022

Crick labs

Full details

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

Authors (9)

Nature Structural and Molecular Biology

Published 1 January 2022

Crick labs/ facilities

Full details

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

Authors (5)

Nature

Published 20 November 2019

Crick labs/ facilities

Full details

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Authors (12)

Panchali Goswami
Ferdos Abid Ali
Max E Douglas
Julia Locke
Andrew Purkiss
Agnieszka Janska
[...]
Anne Early
Andrea Nans
Alan MC Cheung
John Diffley
Alessandro Costa

Nature Communications

Published 29 November 2018

Crick labs/ facilities

Full details

The mechanism of eukaryotic CMG helicase activation

Authors (4)

Max E Douglas
Ferdos Abid Ali
Alessandro Costa
John Diffley

Nature

Published 8 March 2018

Crick labs/ facilities

Full details

Cryo-EM structure of a licensed DNA replication origin

Authors (7)

Nature Communications

Published 21 December 2017

Crick labs/ facilities

Full details

Cdt1 stabilizes an open MCM ring for helicase loading

Authors (10)

Jordi Frigola
Jun He
Kerstin Kinkelin
Val Pye
Ludovic Renault
Max E Douglas
Dirk Remus
Peter Cherepanov
Alessandro Costa
John Diffley

Nature Communications

Published 23 June 2017

Crick labs/ facilities

Full details

CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome

Authors (8)

Jin Chuan Zhou
Agnieszka Janska
Panchali Goswami
Ludovic Renault
Ferdos Abid Ali
Abhay Kotecha
John Diffley
Alessandro Costa

Proceedings of the National Academy of Sciences of the United States of America

Published 18 April 2017

Crick labs/ facilities

Full details

Research case studies

Postdoctoral clinical fellows

Hello Brain!

News and reports

About us

Diffley lab
Chromosome Replication Laboratory
: Publications

Lab content

Publications

Year published

Research topics

Publication type

Journal

Mechanism of replication origin melting nucleated by CMG helicase assembly

The initiation of eukaryotic DNA replication

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

The mechanism of eukaryotic CMG helicase activation

Cryo-EM structure of a licensed DNA replication origin

Cdt1 stabilizes an open MCM ring for helicase loading

CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome

The Francis Crick Institute is a unique partnership between

Research case studies

Postdoctoral clinical fellows

Hello Brain!

News and reports

About us

Lab content

Publications

Year published

Research topics

Publication type

Journal

Publications

Share the page

The Francis Crick Institute is a unique partnership between