Publications

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

Authors (9)

Nature Structural and Molecular Biology

Published 1 January 2022

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Eukaryotic DNA replication with purified budding yeast proteins

Authors (3)

Viktor Posse
Erik Johansson
John Diffley

Methods in Enzymology

Published 1 January 2021

Crick labs/ facilities

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Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

Authors (2)

eLife

Published 13 August 2021

Crick labs/ facilities

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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease

Authors (14)

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

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Author's overview: identifying SARS-CoV-2 antiviral compounds

Authors (1)

John Diffley

Biochemical Journal

Published 16 July 2021

Crick labs

John Diffley

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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease

Authors (22)

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase

Authors (12)

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

Authors (19)

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

Authors (19)

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase

Authors (21)

Saz Basu
Tiffany Mak
Rachel Ulferts
Mary Wu
Tom Deegan
Ryo Fujisawa
[...]
Rupert Beale
Victoria H Cowling
Michael Howell
Karim Labib
John Diffley

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

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An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques

Authors (6)

RSC Advances: an international journal to further the chemical sciences

Published 8 June 2021

Crick labs/ facilities

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Unchecked nick ligation can promote localized genome re-replication

Authors (2)

Erik Johansson
John Diffley

Current Biology

Published 7 June 2021

Crick labs/ facilities

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Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro

Authors (2)

Max E Douglas
John Diffley

Nucleic Acids Research

Published 4 June 2021

Crick labs/ facilities

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DNA replication origins retain mobile licensing proteins

Authors (8)

Humberto Sánchez
Kaley McCluskey
Theo van Laar
Edo van Veen
Filip M Asscher
Belén Solano
John Diffley
Nynke H Dekker

Nature Communications

Published 26 March 2021

Crick labs

John Diffley

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Chromosome Replication Laboratory
: Publications

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Publications

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Publication type

Journal

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

Eukaryotic DNA replication with purified budding yeast proteins

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease

Author's overview: identifying SARS-CoV-2 antiviral compounds

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques

Unchecked nick ligation can promote localized genome re-replication

Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro

DNA replication origins retain mobile licensing proteins

The Francis Crick Institute is a unique partnership between

Research case studies

Postdoctoral clinical fellows

Hello Brain!

News and reports

About us

Lab content

Publications

Year published

Research topics

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Journal

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