Publications

A mitotic stopwatch determines cell fate

Authors (2)

Agostina Bertolin
Vanesa Gottifredi

Science

Published 29 March 2024

Crick labs

John Diffley

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A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint

Authors (6)

Humberto Sánchez
Zhaowei Liu
Edo van Veen
Theo van Laar
John Diffley
Nynke H Dekker

Nature Communications

Published 23 October 2023

Crick labs

John Diffley

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Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation

Authors (7)

Daniel Ramírez Montero
Humberto Sánchez
Edo van Veen
Theo van Laar
Belén Solano
John Diffley
Nynke H Dekker

Nature Communications

Published 14 April 2023

Crick labs

John Diffley

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A replication fork determinant for the establishment of sister chromatid cohesion

Authors (5)

Cell

Published 16 February 2023

Crick labs/ facilities

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Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication

Authors (4)

Cell

Published 20 January 2023

Crick labs/ facilities

Full details

A DNA replication fork-centric view of the budding yeast DNA damage response

Authors (3)

DNA Repair

Published 1 November 2022

Crick labs

John Diffley

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Mechanism of replication origin melting nucleated by CMG helicase assembly

Authors (8)

Nature

Published 30 June 2022

Crick labs/ facilities

Full details

The initiation of eukaryotic DNA replication

Authors (2)

Annual Review of Biochemistry

Published 1 June 2022

Crick labs

Full details

Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae

Authors (8)

Jasmin Philip
Mihkel Örd
Andriele Silva
Shaneen Singh
John Diffley
Dirk Remus
Mart Loog
Amy E Ikui

eLife

Published 10 February 2022

Crick labs

John Diffley

Full details

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

Authors (9)

Nature Structural and Molecular Biology

Published 1 January 2022

Crick labs/ facilities

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Eukaryotic DNA replication with purified budding yeast proteins

Authors (3)

Viktor Posse
Erik Johansson
John Diffley

Methods in Enzymology

Published 1 January 2021

Crick labs/ facilities

Full details

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

Authors (2)

eLife

Published 13 August 2021

Crick labs/ facilities

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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease

Authors (14)

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

Full details

Author's overview: identifying SARS-CoV-2 antiviral compounds

Authors (1)

John Diffley

Biochemical Journal

Published 16 July 2021

Crick labs

John Diffley

Full details

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease

Authors (22)

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase

Authors (12)

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

Full details

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

Authors (19)

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

Full details

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

Authors (19)

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

Full details

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase

Authors (21)

Saz Basu
Tiffany Mak
Rachel Ulferts
Mary Wu
Tom Deegan
Ryo Fujisawa
[...]
Rupert Beale
Victoria H Cowling
Michael Howell
Karim Labib
John Diffley

Biochemical Journal

Published 16 July 2021

Crick labs/ facilities

Full details

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A mitotic stopwatch determines cell fate

A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint

Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation

A replication fork determinant for the establishment of sister chromatid cohesion

Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication

A DNA replication fork-centric view of the budding yeast DNA damage response

Mechanism of replication origin melting nucleated by CMG helicase assembly

The initiation of eukaryotic DNA replication

Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

Eukaryotic DNA replication with purified budding yeast proteins

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease

Author's overview: identifying SARS-CoV-2 antiviral compounds

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

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