Publications

An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques

Authors (6)

RSC Advances: an international journal to further the chemical sciences

Published 8 June 2021

Crick labs/ facilities

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Unchecked nick ligation can promote localized genome re-replication

Authors (2)

Erik Johansson
John Diffley

Current Biology

Published 7 June 2021

Crick labs/ facilities

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Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro

Authors (2)

Max E Douglas
John Diffley

Nucleic Acids Research

Published 4 June 2021

Crick labs/ facilities

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DNA replication origins retain mobile licensing proteins

Authors (8)

Humberto Sánchez
Kaley McCluskey
Theo van Laar
Edo van Veen
Filip M Asscher
Belén Solano
John Diffley
Nynke H Dekker

Nature Communications

Published 26 March 2021

Crick labs

John Diffley

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Multiplex cell fate tracking by flow cytometry

Authors (4)

Methods and Protocols

Published 17 July 2020

Crick labs/ facilities

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Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

Authors (5)

Nature

Published 20 November 2019

Crick labs/ facilities

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A role for chromatin remodeling in cohesin loading onto chromosomes

Authors (5)

Sofia Munoz-Felix
Masashi Minamino
Corella S Casas-Delucchi
Harshil Patel
Frank Uhlmann

Molecular Cell

Published 16 May 2019

Crick labs/ facilities

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Rpd3L contributes to the DNA damage sensitivity of Saccharomyces cerevisiae checkpoint mutants

Authors (4)

Belén Gómez-González
Harshil Patel
Anne Early
John Diffley

Genetics

Published 1 February 2019

Crick labs/ facilities

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Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Authors (12)

Panchali Goswami
Ferdos Abid Ali
Max E Douglas
Julia Locke
Andrew Purkiss
Agnieszka Janska
[...]
Anne Early
Andrea Nans
Alan MC Cheung
John Diffley
Alessandro Costa

Nature Communications

Published 29 November 2018

Crick labs/ facilities

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The mechanism of eukaryotic CMG helicase activation

Authors (4)

Max E Douglas
Ferdos Abid Ali
Alessandro Costa
John Diffley

Nature

Published 8 March 2018

Crick labs/ facilities

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Cryo-EM structure of a licensed DNA replication origin

Authors (7)

Nature Communications

Published 21 December 2017

Crick labs/ facilities

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Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

Authors (2)

Science

Published 21 July 2017

Crick labs/ facilities

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Cdt1 stabilizes an open MCM ring for helicase loading

Authors (10)

Jordi Frigola
Jun He
Kerstin Kinkelin
Val Pye
Ludovic Renault
Max E Douglas
Dirk Remus
Peter Cherepanov
Alessandro Costa
John Diffley

Nature Communications

Published 23 June 2017

Crick labs/ facilities

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CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome

Authors (8)

Jin Chuan Zhou
Agnieszka Janska
Panchali Goswami
Ludovic Renault
Ferdos Abid Ali
Abhay Kotecha
John Diffley
Alessandro Costa

Proceedings of the National Academy of Sciences of the United States of America

Published 18 April 2017

Crick labs/ facilities

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Chromatin controls DNA replication origin selection, lagging-strand synthesis, and replication fork rates

Authors (5)

Christoph F Kurat
Joseph TP Yeeles
Harshil Patel
Anne Early
John Diffley

Molecular Cell

Published 5 January 2017

Crick labs/ facilities

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How the eukaryotic replisome achieves rapid and efficient DNA replication

Authors (4)

Joseph TP Yeeles
Agnieska Janska
Anne Early
John Diffley

Molecular Cell

Published 5 January 2017

Crick labs/ facilities

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Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation

Authors (3)

Tom D Deegan
Joseph TP Yeeles
John Diffley

EMBO Journal

Published 2 May 2016

Crick labs/ facilities

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MCM: one ring to rule them all

Authors (2)

Tom D Deegan
John Diffley

Current Opinion in Structural Biology

Published 8 February 2016

Crick labs

John Diffley

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On the road to replication

Authors (1)

John Diffley

EMBO Molecular Medicine

Published 19 January 2016

Crick labs

John Diffley

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Recruitment of Mcm10 to sites of replication initiation requires direct binding to the minichromosome maintenance (MCM) complex

Authors (2)

Max E Douglas
John Diffley

Journal of Biological Chemistry

Published 11 March 2016

Crick labs/ facilities

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An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques

Unchecked nick ligation can promote localized genome re-replication

Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro

DNA replication origins retain mobile licensing proteins

Multiplex cell fate tracking by flow cytometry

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

A role for chromatin remodeling in cohesin loading onto chromosomes

Rpd3L contributes to the DNA damage sensitivity of Saccharomyces cerevisiae checkpoint mutants

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

The mechanism of eukaryotic CMG helicase activation

Cryo-EM structure of a licensed DNA replication origin

Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

Cdt1 stabilizes an open MCM ring for helicase loading

CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome

Chromatin controls DNA replication origin selection, lagging-strand synthesis, and replication fork rates

How the eukaryotic replisome achieves rapid and efficient DNA replication

Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation

MCM: one ring to rule them all

On the road to replication

Recruitment of Mcm10 to sites of replication initiation requires direct binding to the minichromosome maintenance (MCM) complex

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Research case studies

Postdoctoral clinical fellows

Hello Brain!

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Research topics

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