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Breadcrumb Julian Downward Downward lab Oncogene Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Mass cytometry images of carcinogen induced lung tumours in mice. 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Biology (1)Nature Medicine (1)Nature Protocols (1)Science advances (1) Facet Journal Publications Displaying 1 - 20 of 91Last updated : 28 May 2023 03:49 Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4 Authors (40) J Chauhan M Grandits LCGF Palhares S Mele M Nakamura J López-Abente[...] P Karagiannis KE Lacy J Spicer SN Karagiannis HJ Bax Nature Communications Published 25 April 2023 Crick labsJulian DownwardFull details Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details Genomic-transcriptomic evolution in lung cancer and metastasis Authors (47) Carlos Martínez-Ruiz James RM Black Clare Puttick Mark S HillJonas DemeulemeesterElizabeth Larose Cadieux[...] Peter Van Loo Mariam Jamal-Hanjani TRACERx Consortium Charles Swanton Nicholas McGranahan Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α Authors (18)Soly Ismail Stephen R MartinRoger GeorgeFrankie HoughtonGeoff KellyRaphael Chaleil[...] Ning Sze HuiMiriam Molina ArcasDavid Hancock Ali TavassoliJulian Downward Scientific Reports Published 2 February 2023 Crick labs/ facilitiesJulian DownwardPaul BatesStructural BiologyPeptide ChemistryMRC Biomedical NMR CentreFull details Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice Authors (6) May Zaw ThinChristopher MooreThomas Snoeks Tammy KalberJulian DownwardAxel Behrens Nature Protocols Published 1 March 2023 Crick labs/ facilitiesJulian DownwardAxel BehrensIn Vivo ImagingBiological Research FacilityFull details Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsGenomics/Equipment ParkBioinformatics and BiostatisticsLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma Authors (11)Phil EastGavin KellyDhruva Biswas Michela MaraniDavid Hancock Todd Creasy Kris SachsenmeierCharles Swanton TRACERx consortiumJulian DownwardSophie de Carne Nature Communications Published 26 September 2022 Crick labs/ facilitiesCharles SwantonJulian DownwardBioinformatics and BiostatisticsFull details An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations Authors (26)Jesse BoumelhaSophie de Carne Emily K Law Pablo Romero-Clavijo Matthew A CoelhoKevin Ng[...]George KassiotisMiriam Molina ArcasCharles Swanton Reuben HarrisJulian Downward Cancer Research Published 1 October 2022 Crick labs/ facilitiesCharles SwantonGeorge KassiotisJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsScientific computingFlow CytometryCell ServicesBiological Research FacilityFull details Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers Authors (14) Edurne MugarzaFebe Van MaldegemJesse BoumelhaChristopher MooreSareena Rana Miriam Llorian Sopena[...] Pablo Romero-ClavijoKarishma ValandMegan ColeMiriam Molina ArcasJulian Downward Science advances Published 22 July 2022 Crick labs/ facilitiesJulian DownwardBioinformatics and BiostatisticsGenomics/Equipment ParkFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details The potency of a KRAS silent variant Authors (2)Miriam Molina ArcasJulian Downward New England Journal of Medicine Published 30 June 2022 Crick labsJulian DownwardFull details Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition Authors (8) Tereza Vaclova Atanu Chakraborty James Sherwood Sarah Ross Danielle Carroll J Carl BarrettJulian Downward Elza C de Bruin Scientific Reports Published 17 February 2022 Crick labsJulian DownwardFull details Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry Authors (18)Febe Van MaldegemKarishma ValandMegan Cole Harshil PatelMihaela AngelovaSareena Rana[...]Philip HobsonDina LeviMiriam Molina ArcasCharles SwantonJulian Downward Nature Communications Published 8 October 2021 Crick labs/ facilitiesCharles SwantonJulian DownwardFlow CytometryBioinformatics and BiostatisticsScientific computingLight MicroscopyExperimental HistopathologyCell ServicesBiological Research FacilityFull details Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis Authors (19) Liudi Yao Yilu Zhou Juanjuan Li Leanne Wickens Franco Conforti Anna Rattu[...] Luca Richeldi Paul Skipp Donna E Davies Mark G Jones Yihua Wang Journal of Biological Chemistry Published 1 September 2021 Crick labsJulian DownwardFull details Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer Authors (43) Stelios Chrysostomou Rajat Roy Filippo Prischi Lucksamon Thamlikitkul Kathryn L Chapman Uwais Mufti[...]Julian DownwardMark Skehel Maruf MU Ali Michael J Seckl Olivier E Pardo Science Translational Medicine Published 14 July 2021 Crick labsJulian DownwardFull details JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer Authors (13)Josue RuizLinxiang Lan Markus Elmar Diefenbacher Eva Madi RiisingClive Da Costa Atanu Chakraborty[...]Gavin Kelly Jean-Pierre DavidEmma NyeJulian DownwardAxel Behrens JCI insight Published 8 July 2021 Crick labs/ facilitiesJulian DownwardAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsFull details Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype Authors (46) Satyamaanasa PolubothuDavide Zecchin Lara Al-Olabi Daniël A Lionarons Mark Harland Stuart Horswell[...] Gudrun E Moore Wei-Li Di Julia Newton-BishopJulian DownwardVeronica Kinsler Genetics in Medicine Published 1 September 2021 Crick labs/ facilitiesVeronica KinslerJulian DownwardHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingFull details Drugging the undruggable: Advances on RAS targeting in cancer Authors (3)Miriam Molina ArcasAmit SamaniJulian Downward Genes (Basel) Published 10 June 2021 Crick labsJulian DownwardFull details Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers Authors (13) Tereza Vaclova Ursula Grazini Lewis Ward Daniel O'Neill Aleksandra Markovets Xiangning Huang[...] Kenneth S Thress Paul D Smith J Carl BarrettJulian Downward Elza C de Bruin Nature Communications Published 19 March 2021 Crick labsJulian DownwardFull details Quantitative proteomic analysis in alveolar type II cells reveals the different capacities of RAS and TGF-β to induce epithelial-mesenchymal transition Authors (11) Yilu Zhou Charlotte Hill Liudi Yao Juanjuan LiDavid HancockJulian Downward Mark G Jones Donna E Davies Rob M Ewing Paul Skipp Yihua Wang Frontiers in Molecular Biosciences Published 19 March 2021 Crick labsJulian DownwardFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4 Authors (40) J Chauhan M Grandits LCGF Palhares S Mele M Nakamura J López-Abente[...] P Karagiannis KE Lacy J Spicer SN Karagiannis HJ Bax Nature Communications Published 25 April 2023 Crick labsJulian DownwardFull details
Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details
Genomic-transcriptomic evolution in lung cancer and metastasis Authors (47) Carlos Martínez-Ruiz James RM Black Clare Puttick Mark S HillJonas DemeulemeesterElizabeth Larose Cadieux[...] Peter Van Loo Mariam Jamal-Hanjani TRACERx Consortium Charles Swanton Nicholas McGranahan Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details
Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α Authors (18)Soly Ismail Stephen R MartinRoger GeorgeFrankie HoughtonGeoff KellyRaphael Chaleil[...] Ning Sze HuiMiriam Molina ArcasDavid Hancock Ali TavassoliJulian Downward Scientific Reports Published 2 February 2023 Crick labs/ facilitiesJulian DownwardPaul BatesStructural BiologyPeptide ChemistryMRC Biomedical NMR CentreFull details
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice Authors (6) May Zaw ThinChristopher MooreThomas Snoeks Tammy KalberJulian DownwardAxel Behrens Nature Protocols Published 1 March 2023 Crick labs/ facilitiesJulian DownwardAxel BehrensIn Vivo ImagingBiological Research FacilityFull details
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsGenomics/Equipment ParkBioinformatics and BiostatisticsLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details
RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma Authors (11)Phil EastGavin KellyDhruva Biswas Michela MaraniDavid Hancock Todd Creasy Kris SachsenmeierCharles Swanton TRACERx consortiumJulian DownwardSophie de Carne Nature Communications Published 26 September 2022 Crick labs/ facilitiesCharles SwantonJulian DownwardBioinformatics and BiostatisticsFull details
An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations Authors (26)Jesse BoumelhaSophie de Carne Emily K Law Pablo Romero-Clavijo Matthew A CoelhoKevin Ng[...]George KassiotisMiriam Molina ArcasCharles Swanton Reuben HarrisJulian Downward Cancer Research Published 1 October 2022 Crick labs/ facilitiesCharles SwantonGeorge KassiotisJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsScientific computingFlow CytometryCell ServicesBiological Research FacilityFull details
Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers Authors (14) Edurne MugarzaFebe Van MaldegemJesse BoumelhaChristopher MooreSareena Rana Miriam Llorian Sopena[...] Pablo Romero-ClavijoKarishma ValandMegan ColeMiriam Molina ArcasJulian Downward Science advances Published 22 July 2022 Crick labs/ facilitiesJulian DownwardBioinformatics and BiostatisticsGenomics/Equipment ParkFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
The potency of a KRAS silent variant Authors (2)Miriam Molina ArcasJulian Downward New England Journal of Medicine Published 30 June 2022 Crick labsJulian DownwardFull details
Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition Authors (8) Tereza Vaclova Atanu Chakraborty James Sherwood Sarah Ross Danielle Carroll J Carl BarrettJulian Downward Elza C de Bruin Scientific Reports Published 17 February 2022 Crick labsJulian DownwardFull details
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry Authors (18)Febe Van MaldegemKarishma ValandMegan Cole Harshil PatelMihaela AngelovaSareena Rana[...]Philip HobsonDina LeviMiriam Molina ArcasCharles SwantonJulian Downward Nature Communications Published 8 October 2021 Crick labs/ facilitiesCharles SwantonJulian DownwardFlow CytometryBioinformatics and BiostatisticsScientific computingLight MicroscopyExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis Authors (19) Liudi Yao Yilu Zhou Juanjuan Li Leanne Wickens Franco Conforti Anna Rattu[...] Luca Richeldi Paul Skipp Donna E Davies Mark G Jones Yihua Wang Journal of Biological Chemistry Published 1 September 2021 Crick labsJulian DownwardFull details
Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer Authors (43) Stelios Chrysostomou Rajat Roy Filippo Prischi Lucksamon Thamlikitkul Kathryn L Chapman Uwais Mufti[...]Julian DownwardMark Skehel Maruf MU Ali Michael J Seckl Olivier E Pardo Science Translational Medicine Published 14 July 2021 Crick labsJulian DownwardFull details
JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer Authors (13)Josue RuizLinxiang Lan Markus Elmar Diefenbacher Eva Madi RiisingClive Da Costa Atanu Chakraborty[...]Gavin Kelly Jean-Pierre DavidEmma NyeJulian DownwardAxel Behrens JCI insight Published 8 July 2021 Crick labs/ facilitiesJulian DownwardAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsFull details
Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype Authors (46) Satyamaanasa PolubothuDavide Zecchin Lara Al-Olabi Daniël A Lionarons Mark Harland Stuart Horswell[...] Gudrun E Moore Wei-Li Di Julia Newton-BishopJulian DownwardVeronica Kinsler Genetics in Medicine Published 1 September 2021 Crick labs/ facilitiesVeronica KinslerJulian DownwardHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingFull details
Drugging the undruggable: Advances on RAS targeting in cancer Authors (3)Miriam Molina ArcasAmit SamaniJulian Downward Genes (Basel) Published 10 June 2021 Crick labsJulian DownwardFull details
Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers Authors (13) Tereza Vaclova Ursula Grazini Lewis Ward Daniel O'Neill Aleksandra Markovets Xiangning Huang[...] Kenneth S Thress Paul D Smith J Carl BarrettJulian Downward Elza C de Bruin Nature Communications Published 19 March 2021 Crick labsJulian DownwardFull details
Quantitative proteomic analysis in alveolar type II cells reveals the different capacities of RAS and TGF-β to induce epithelial-mesenchymal transition Authors (11) Yilu Zhou Charlotte Hill Liudi Yao Juanjuan LiDavid HancockJulian Downward Mark G Jones Donna E Davies Rob M Ewing Paul Skipp Yihua Wang Frontiers in Molecular Biosciences Published 19 March 2021 Crick labsJulian DownwardFull details