Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Julian Downward Downward lab Oncogene Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Mass cytometry images of carcinogen induced lung tumours in mice. Toggle to view hero caption PublicationsYear published2023 (1)2022 (1)2018 (1)2015 (1) Facet Year publishedResearch topicsChemical Biology & High Throughput (4)Gene Expression (4)Genetics & Genomics (4)Model Organisms (4)Signalling & Oncogenes (4)Tumour Biology (4)Computational & Systems Biology (1)Structural Biology & Biophysics (1) Facet Research topicsPublication typeJournal article (4)Primary research (4) Facet Publication typeJournal (-)Scientific Reports (4) Facet Journal Publications Displaying 1 - 4 of 4Last updated : 28 March 2024 03:09 Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α Authors (18)Soly Ismail Stephen R MartinRoger GeorgeFrankie HoughtonGeoff KellyRaphael Chaleil[...] Ning Sze HuiMiriam Molina ArcasDavid Hancock Ali TavassoliJulian Downward Scientific Reports Published 2 February 2023 Crick labs/ facilitiesJulian DownwardPaul BatesStructural BiologyMRC Biomedical NMR CentreFull details Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition Authors (8) Tereza Vaclova Atanu Chakraborty James Sherwood Sarah Ross Danielle Carroll J Carl BarrettJulian Downward Elza C de Bruin Scientific Reports Published 17 February 2022 Crick labsJulian DownwardFull details AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons Authors (13) Marc PM Soutar Liam Kempthorne Shuichi Miyakawa Emily Annuario Daniela MelandriJasmine Harley[...]David Hancock Mark R CooksonJulian Downward Mark Carlton Hélène Plun-Favreau Scientific Reports Published 11 June 2018 Crick labsJulian DownwardFull details Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism Authors (4) Francesco Gatto Heike Miess Almut Schulze Jens Nielsen Scientific Reports Published 4 June 2015 Crick labs/ facilitiesJulian DownwardHigh Throughput ScreeningFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α Authors (18)Soly Ismail Stephen R MartinRoger GeorgeFrankie HoughtonGeoff KellyRaphael Chaleil[...] Ning Sze HuiMiriam Molina ArcasDavid Hancock Ali TavassoliJulian Downward Scientific Reports Published 2 February 2023 Crick labs/ facilitiesJulian DownwardPaul BatesStructural BiologyMRC Biomedical NMR CentreFull details
Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition Authors (8) Tereza Vaclova Atanu Chakraborty James Sherwood Sarah Ross Danielle Carroll J Carl BarrettJulian Downward Elza C de Bruin Scientific Reports Published 17 February 2022 Crick labsJulian DownwardFull details
AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons Authors (13) Marc PM Soutar Liam Kempthorne Shuichi Miyakawa Emily Annuario Daniela MelandriJasmine Harley[...]David Hancock Mark R CooksonJulian Downward Mark Carlton Hélène Plun-Favreau Scientific Reports Published 11 June 2018 Crick labsJulian DownwardFull details
Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism Authors (4) Francesco Gatto Heike Miess Almut Schulze Jens Nielsen Scientific Reports Published 4 June 2015 Crick labs/ facilitiesJulian DownwardHigh Throughput ScreeningFull details