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Breadcrumb Julian Downward Downward lab Oncogene Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Mass cytometry images of carcinogen induced lung tumours in mice. Toggle to view hero caption PublicationsYear published2024 (1)2023 (4)2021 (1)2020 (1)2016 (1) Facet Year publishedResearch topicsChemical Biology & High Throughput (8)Gene Expression (8)Genetics & Genomics (8)Model Organisms (8)Signalling & Oncogenes (8)Tumour Biology (8)Cell Biology (7)Genome Integrity & Repair (6)Human Biology & Physiology (6)Stem Cells (6)Computational & Systems Biology (5)Immunology (5)Biochemistry & Proteomics (2)Developmental Biology (2)Infectious Disease (2)Structural Biology & Biophysics (2)Metabolism (1) (-)Cell Cycle & Chromosomes (8) Facet Research topicsPublication typeJournal article (8)Primary research (7)Obituary (1) Facet Publication typeJournalNature (3)Nature Communications (2)Angewandte Chemie International Edition (1)Biochemical Journal (1)Nature Biotechnology (1) Facet Journal Publications Displaying 1 - 8 of 8Last updated : 28 March 2024 03:17 A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Authors (16) Cory A Ocasio Marc P Baggelaar James Sipthorp Ana Losada de la Lastra Manuel Tavares Jana Volarić[...]Goran TomicCharlotte CarrJulian Downward Ulrike S Eggert Edward W Tate Nature Biotechnology Published 8 January 2024 Crick labs/ facilitiesEd TateJulian DownwardMetabolomicsFlow CytometryChemical BiologyProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details Michael D. Waterfield Authors (3)Julian DownwardPeter Parker Bart Vanhaesebroeck Biochemical Journal Published 27 September 2023 Crick labsPeter ParkerJulian DownwardFull details Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details Genomic-transcriptomic evolution in lung cancer and metastasis Authors (47) Carlos Martínez-Ruiz James RM Black Clare Puttick Mark S HillJonas DemeulemeesterElizabeth Larose Cadieux[...] Peter Van Loo Mariam Jamal-Hanjani TRACERx Consortium Charles Swanton Nicholas McGranahan Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry Authors (18)Febe VanMaldegemKarishma ValandMegan Cole Harshil PatelMihaela AngelovaSareena Rana[...]Philip HobsonDina LeviMiriam Molina ArcasCharles SwantonJulian Downward Nature Communications Published 8 October 2021 Crick labs/ facilitiesCharles SwantonJulian DownwardFlow CytometryBioinformatics and BiostatisticsScientific computingLight MicroscopyExperimental HistopathologyCell ServicesBiological Research FacilityFull details IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche Authors (17) Sissy E Wamaitha Katarzyna J GrybelGregorio Alanis LobatoClaudia GerriSugako OgushiAfshan Mccarthy[...] Phil Snell Leila ChristieJulian DownwardJames TurnerKathy Niakan Nature Communications Published 7 February 2020 Crick labs/ facilitiesJames TurnerKathy NiakanJulian DownwardHuman Embryonic Stem CellScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsFull details HF-free Boc synthesis of peptide thioesters for ligation and cyclization Authors (9) Richard Raz Fabienne BurlinaSoly IsmailJulian Downward Jiejin Li Stephen J Smerdon Martin Quibell Peter D White John Offer Angewandte Chemie International Edition Published 10 October 2016 Crick labsSteve SmerdonJulian DownwardFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Authors (16) Cory A Ocasio Marc P Baggelaar James Sipthorp Ana Losada de la Lastra Manuel Tavares Jana Volarić[...]Goran TomicCharlotte CarrJulian Downward Ulrike S Eggert Edward W Tate Nature Biotechnology Published 8 January 2024 Crick labs/ facilitiesEd TateJulian DownwardMetabolomicsFlow CytometryChemical BiologyProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details
Michael D. Waterfield Authors (3)Julian DownwardPeter Parker Bart Vanhaesebroeck Biochemical Journal Published 27 September 2023 Crick labsPeter ParkerJulian DownwardFull details
Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details
Genomic-transcriptomic evolution in lung cancer and metastasis Authors (47) Carlos Martínez-Ruiz James RM Black Clare Puttick Mark S HillJonas DemeulemeesterElizabeth Larose Cadieux[...] Peter Van Loo Mariam Jamal-Hanjani TRACERx Consortium Charles Swanton Nicholas McGranahan Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry Authors (18)Febe VanMaldegemKarishma ValandMegan Cole Harshil PatelMihaela AngelovaSareena Rana[...]Philip HobsonDina LeviMiriam Molina ArcasCharles SwantonJulian Downward Nature Communications Published 8 October 2021 Crick labs/ facilitiesCharles SwantonJulian DownwardFlow CytometryBioinformatics and BiostatisticsScientific computingLight MicroscopyExperimental HistopathologyCell ServicesBiological Research FacilityFull details
IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche Authors (17) Sissy E Wamaitha Katarzyna J GrybelGregorio Alanis LobatoClaudia GerriSugako OgushiAfshan Mccarthy[...] Phil Snell Leila ChristieJulian DownwardJames TurnerKathy Niakan Nature Communications Published 7 February 2020 Crick labs/ facilitiesJames TurnerKathy NiakanJulian DownwardHuman Embryonic Stem CellScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsFull details
HF-free Boc synthesis of peptide thioesters for ligation and cyclization Authors (9) Richard Raz Fabienne BurlinaSoly IsmailJulian Downward Jiejin Li Stephen J Smerdon Martin Quibell Peter D White John Offer Angewandte Chemie International Edition Published 10 October 2016 Crick labsSteve SmerdonJulian DownwardFull details