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Breadcrumb Julian Downward Downward lab Oncogene Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Mass cytometry images of carcinogen induced lung tumours in mice. Toggle to view hero caption PublicationsYear published2024 (3)2023 (8)2022 (7)2021 (8)2020 (7)2019 (7)2018 (6)2017 (1)2016 (5)2015 (5) Facet Year publishedResearch topicsGenetics & Genomics (57)Tumour Biology (57)Chemical Biology & High Throughput (56)Gene Expression (56)Model Organisms (56)Genome Integrity & Repair (20)Computational & Systems Biology (19)Human Biology & Physiology (15)Stem Cells (10)Cell Biology (9)Immunology (9)Cell Cycle & Chromosomes (8)Biochemistry & Proteomics (6)Structural Biology & Biophysics (6)Developmental Biology (5)Imaging (3)Infectious Disease (3)Metabolism (2) (-)Signalling & Oncogenes (57) Facet Research topicsPublication typeJournal article (57)Primary research (46)Review (4)Commentary (3)Method (3)Obituary (1) Facet Publication typeJournalNature Communications (8)Scientific Reports (4)Nature (3)Cancer Cell (2)Cancer Research (2)Cell Death and Disease (2)Clinical cancer research (2)EMBO Molecular Medicine (2)Immunity (2)Oncogene (2)Proceedings of the National Academy of Sciences of the United States of America (2)Science Translational Medicine (2)Wellcome Open Research (2)Angewandte Chemie International Edition (1)Autophagy (1)Biochemical Journal (1)Cancer Discovery (1)Cell (1)Cell Death and Differentiation (1)Cell Discovery (1)Cell Reports (1)FEBS Journal (1)Frontiers in Molecular Biosciences (1)Genes (Basel) (1)Genes and Diseases (1)Genetics in Medicine (1)JCI insight (1)Journal of Biological Chemistry (1)Molecular Oncology (1)Nature Biotechnology (1)Nature Protocols (1)New England Journal of Medicine (1)PLOS ONE (1)Science advances (1)Science Signaling (1) Facet Journal Publications Displaying 1 - 20 of 57Last updated : 19 April 2024 02:11 Spatial architecture of myeloid and T cells orchestrates immune evasion and clinical outcome in lung cancer Authors (35)Katey Enfield Emma Colliver Claudia Lee Alastair Magness David A Moore Monica Sivakumar[...]Crispin HileyJulian DownwardErik SahaiCharles SwantonMihaela Angelova Cancer Discovery Published 6 April 2024 Crick labs/ facilitiesCharles SwantonErik SahaiJulian DownwardFlow CytometryExperimental HistopathologyScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Exploiting the therapeutic implications of KRAS inhibition on tumor immunity Authors (2)Miriam Molina ArcasJulian Downward Cancer Cell Published 11 March 2024 Crick labsJulian DownwardFull details A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Authors (16) Cory A Ocasio Marc P Baggelaar James Sipthorp Ana Losada de la Lastra Manuel Tavares Jana Volarić[...]Goran TomicCharlotte CarrJulian Downward Ulrike S Eggert Edward W Tate Nature Biotechnology Published 8 January 2024 Crick labs/ facilitiesEd TateJulian DownwardMetabolomicsFlow CytometryChemical BiologyProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details Michael D. Waterfield Authors (3)Julian DownwardPeter Parker Bart Vanhaesebroeck Biochemical Journal Published 27 September 2023 Crick labsPeter ParkerJulian DownwardFull details Facts and hopes on RAS inhibitors and cancer immunotherapy Authors (3)Jesse BoumelhaMiriam Molina ArcasJulian Downward Clinical cancer research Published 15 December 2023 Crick labsJulian DownwardFull details LKB1 depletion-mediated epithelial–mesenchymal transition induces fibroblast activation in lung fibrosis Authors (14) Zijian Xu Elizabeth R Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani[...]Julian Downward Rob M Ewing Donna E Davies Mark G Jones Yihua Wang Genes and Diseases Published 1 May 2024 Crick labsJulian DownwardFull details Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4 Authors (40) J Chauhan M Grandits LCGF Palhares S Mele M Nakamura J López-Abente[...] P Karagiannis KE Lacy J Spicer SN Karagiannis HJ Bax Nature Communications Published 25 April 2023 Crick labsJulian DownwardFull details Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details Genomic-transcriptomic evolution in lung cancer and metastasis Authors (47) Carlos Martínez-Ruiz James RM Black Clare Puttick Mark S HillJonas DemeulemeesterElizabeth Larose Cadieux[...] Peter Van Loo Mariam Jamal-Hanjani TRACERx Consortium Charles Swanton Nicholas McGranahan Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α Authors (18)Soly Ismail Stephen R MartinRoger GeorgeFrankie HoughtonGeoff KellyRaphael Chaleil[...] Ning Sze HuiMiriam Molina ArcasDavid Hancock Ali TavassoliJulian Downward Scientific Reports Published 2 February 2023 Crick labs/ facilitiesJulian DownwardPaul BatesStructural BiologyMRC Biomedical NMR CentreFull details Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice Authors (6) May Zaw ThinChristopher MooreThomas Snoeks Tammy KalberJulian DownwardAxel Behrens Nature Protocols Published 1 March 2023 Crick labs/ facilitiesJulian DownwardAxel BehrensIn Vivo ImagingBiological Research FacilityFull details Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma Authors (11)Phil EastGavin KellyDhruva Biswas Michela MaraniDavid Hancock Todd Creasy Kris SachsenmeierCharles Swanton TRACERx consortiumJulian DownwardSophie de Carne Nature Communications Published 26 September 2022 Crick labs/ facilitiesCharles SwantonJulian DownwardBioinformatics and BiostatisticsFull details An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations Authors (26)Jesse BoumelhaSophie de Carne Emily K Law Pablo Romero-Clavijo Matthew A CoelhoKevin Ng[...]George KassiotisMiriam Molina ArcasCharles Swanton Reuben HarrisJulian Downward Cancer Research Published 1 October 2022 Crick labs/ facilitiesCharles SwantonGeorge KassiotisJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsScientific computingFlow CytometryCell ServicesBiological Research FacilityFull details Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers Authors (14) Edurne MugarzaFebe VanMaldegemJesse BoumelhaChristopher MooreSareena RanaMiriam Llorian Sopena[...] Pablo Romero-ClavijoKarishma ValandMegan ColeMiriam Molina ArcasJulian Downward Science advances Published 22 July 2022 Crick labs/ facilitiesJulian DownwardBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details The potency of a KRAS silent variant Authors (2)Miriam Molina ArcasJulian Downward New England Journal of Medicine Published 30 June 2022 Crick labsJulian DownwardFull details Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition Authors (8) Tereza Vaclova Atanu Chakraborty James Sherwood Sarah Ross Danielle Carroll J Carl BarrettJulian Downward Elza C de Bruin Scientific Reports Published 17 February 2022 Crick labsJulian DownwardFull details Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry Authors (18)Febe VanMaldegemKarishma ValandMegan Cole Harshil PatelMihaela AngelovaSareena Rana[...]Philip HobsonDina LeviMiriam Molina ArcasCharles SwantonJulian Downward Nature Communications Published 8 October 2021 Crick labs/ facilitiesCharles SwantonJulian DownwardFlow CytometryBioinformatics and BiostatisticsScientific computingLight MicroscopyExperimental HistopathologyCell ServicesBiological Research FacilityFull details Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis Authors (19) Liudi Yao Yilu Zhou Juanjuan Li Leanne Wickens Franco Conforti Anna Rattu[...] Luca Richeldi Paul Skipp Donna E Davies Mark G Jones Yihua Wang Journal of Biological Chemistry Published 1 September 2021 Crick labsJulian DownwardFull details Pagination Current 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Spatial architecture of myeloid and T cells orchestrates immune evasion and clinical outcome in lung cancer Authors (35)Katey Enfield Emma Colliver Claudia Lee Alastair Magness David A Moore Monica Sivakumar[...]Crispin HileyJulian DownwardErik SahaiCharles SwantonMihaela Angelova Cancer Discovery Published 6 April 2024 Crick labs/ facilitiesCharles SwantonErik SahaiJulian DownwardFlow CytometryExperimental HistopathologyScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Exploiting the therapeutic implications of KRAS inhibition on tumor immunity Authors (2)Miriam Molina ArcasJulian Downward Cancer Cell Published 11 March 2024 Crick labsJulian DownwardFull details
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Authors (16) Cory A Ocasio Marc P Baggelaar James Sipthorp Ana Losada de la Lastra Manuel Tavares Jana Volarić[...]Goran TomicCharlotte CarrJulian Downward Ulrike S Eggert Edward W Tate Nature Biotechnology Published 8 January 2024 Crick labs/ facilitiesEd TateJulian DownwardMetabolomicsFlow CytometryChemical BiologyProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details
Michael D. Waterfield Authors (3)Julian DownwardPeter Parker Bart Vanhaesebroeck Biochemical Journal Published 27 September 2023 Crick labsPeter ParkerJulian DownwardFull details
Facts and hopes on RAS inhibitors and cancer immunotherapy Authors (3)Jesse BoumelhaMiriam Molina ArcasJulian Downward Clinical cancer research Published 15 December 2023 Crick labsJulian DownwardFull details
LKB1 depletion-mediated epithelial–mesenchymal transition induces fibroblast activation in lung fibrosis Authors (14) Zijian Xu Elizabeth R Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani[...]Julian Downward Rob M Ewing Donna E Davies Mark G Jones Yihua Wang Genes and Diseases Published 1 May 2024 Crick labsJulian DownwardFull details
Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4 Authors (40) J Chauhan M Grandits LCGF Palhares S Mele M Nakamura J López-Abente[...] P Karagiannis KE Lacy J Spicer SN Karagiannis HJ Bax Nature Communications Published 25 April 2023 Crick labsJulian DownwardFull details
Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details
Genomic-transcriptomic evolution in lung cancer and metastasis Authors (47) Carlos Martínez-Ruiz James RM Black Clare Puttick Mark S HillJonas DemeulemeesterElizabeth Larose Cadieux[...] Peter Van Loo Mariam Jamal-Hanjani TRACERx Consortium Charles Swanton Nicholas McGranahan Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details
Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α Authors (18)Soly Ismail Stephen R MartinRoger GeorgeFrankie HoughtonGeoff KellyRaphael Chaleil[...] Ning Sze HuiMiriam Molina ArcasDavid Hancock Ali TavassoliJulian Downward Scientific Reports Published 2 February 2023 Crick labs/ facilitiesJulian DownwardPaul BatesStructural BiologyMRC Biomedical NMR CentreFull details
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice Authors (6) May Zaw ThinChristopher MooreThomas Snoeks Tammy KalberJulian DownwardAxel Behrens Nature Protocols Published 1 March 2023 Crick labs/ facilitiesJulian DownwardAxel BehrensIn Vivo ImagingBiological Research FacilityFull details
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details
RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma Authors (11)Phil EastGavin KellyDhruva Biswas Michela MaraniDavid Hancock Todd Creasy Kris SachsenmeierCharles Swanton TRACERx consortiumJulian DownwardSophie de Carne Nature Communications Published 26 September 2022 Crick labs/ facilitiesCharles SwantonJulian DownwardBioinformatics and BiostatisticsFull details
An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations Authors (26)Jesse BoumelhaSophie de Carne Emily K Law Pablo Romero-Clavijo Matthew A CoelhoKevin Ng[...]George KassiotisMiriam Molina ArcasCharles Swanton Reuben HarrisJulian Downward Cancer Research Published 1 October 2022 Crick labs/ facilitiesCharles SwantonGeorge KassiotisJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsScientific computingFlow CytometryCell ServicesBiological Research FacilityFull details
Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers Authors (14) Edurne MugarzaFebe VanMaldegemJesse BoumelhaChristopher MooreSareena RanaMiriam Llorian Sopena[...] Pablo Romero-ClavijoKarishma ValandMegan ColeMiriam Molina ArcasJulian Downward Science advances Published 22 July 2022 Crick labs/ facilitiesJulian DownwardBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
The potency of a KRAS silent variant Authors (2)Miriam Molina ArcasJulian Downward New England Journal of Medicine Published 30 June 2022 Crick labsJulian DownwardFull details
Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition Authors (8) Tereza Vaclova Atanu Chakraborty James Sherwood Sarah Ross Danielle Carroll J Carl BarrettJulian Downward Elza C de Bruin Scientific Reports Published 17 February 2022 Crick labsJulian DownwardFull details
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry Authors (18)Febe VanMaldegemKarishma ValandMegan Cole Harshil PatelMihaela AngelovaSareena Rana[...]Philip HobsonDina LeviMiriam Molina ArcasCharles SwantonJulian Downward Nature Communications Published 8 October 2021 Crick labs/ facilitiesCharles SwantonJulian DownwardFlow CytometryBioinformatics and BiostatisticsScientific computingLight MicroscopyExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis Authors (19) Liudi Yao Yilu Zhou Juanjuan Li Leanne Wickens Franco Conforti Anna Rattu[...] Luca Richeldi Paul Skipp Donna E Davies Mark G Jones Yihua Wang Journal of Biological Chemistry Published 1 September 2021 Crick labsJulian DownwardFull details