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Breadcrumb Julian Downward Downward lab Oncogene Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Mass cytometry images of carcinogen induced lung tumours in mice. Toggle to view hero caption PublicationsYear published (-)2018 (6) Facet Year publishedResearch topicsChemical Biology & High Throughput (6)Gene Expression (6)Genetics & Genomics (6)Model Organisms (6)Signalling & Oncogenes (6)Tumour Biology (6)Human Biology & Physiology (1) Facet Research topicsPublication typeJournal article (6)Primary research (6) Facet Publication typeJournalCell Death and Differentiation (1)Cell Reports (1)EMBO Molecular Medicine (1)Oncogene (1)Proceedings of the National Academy of Sciences of the United States of America (1)Scientific Reports (1) Facet Journal Publications Displaying 1 - 6 of 6Last updated : 23 April 2024 03:06 Disruption of the interaction of RAS with PI 3-kinase induces regression of EGFR-mutant-driven lung cancer Authors (6)Miguel MurilloSareena Rana Bradley Spencer-DeneEmma Nye Gordon StampJulian Downward Cell Reports Published 26 December 2018 Crick labs/ facilitiesJulian DownwardExperimental HistopathologyFull details An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors Authors (20) Maicol Mancini Hilah Gal Nadège Gaborit Luigi Mazzeo Donatella Romaniello Tomer Meir Salame[...] Emilie BousquetJulian Downward Antonio Maraver Valery Krizhanovsky Yosef Yarden EMBO Molecular Medicine Published 6 December 2018 Crick labsJulian DownwardFull details Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors Authors (11) N Tsolakos TN Durrant T Chessa SM Suire D Oxley S KulkarniJulian Downward O Perisic RL Williams L Stephens PT Hawkins Proceedings of the National Academy of Sciences of the United States of America Published 15 November 2018 Crick labsJulian DownwardFull details Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis Authors (24) Liudi Yao Franco Conforti Charlotte Hill Joseph Bell Leena Drawater Juanjuan Li[...] Luca Richeldi Paul Skipp Mark G Jones Donna E Davies Yihua Wang Cell Death and Differentiation Published 1 May 2019 Crick labsJulian DownwardFull details AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons Authors (13) Marc PM Soutar Liam Kempthorne Shuichi Miyakawa Emily Annuario Daniela MelandriJasmine Harley[...]David Hancock Mark R CooksonJulian Downward Mark Carlton Hélène Plun-Favreau Scientific Reports Published 11 June 2018 Crick labsJulian DownwardFull details The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma Authors (12) Heike Miess Beatrice Dankworth Arvin M Gouw Mathias Rosenfeldt Werner SchmitzMing Jiang[...]Michael HowellJulian Downward Dean W Felsher Barrie Peck Almut Schulze Oncogene Published 4 October 2018 Crick labs/ facilitiesJulian DownwardHigh Throughput ScreeningFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Disruption of the interaction of RAS with PI 3-kinase induces regression of EGFR-mutant-driven lung cancer Authors (6)Miguel MurilloSareena Rana Bradley Spencer-DeneEmma Nye Gordon StampJulian Downward Cell Reports Published 26 December 2018 Crick labs/ facilitiesJulian DownwardExperimental HistopathologyFull details
An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors Authors (20) Maicol Mancini Hilah Gal Nadège Gaborit Luigi Mazzeo Donatella Romaniello Tomer Meir Salame[...] Emilie BousquetJulian Downward Antonio Maraver Valery Krizhanovsky Yosef Yarden EMBO Molecular Medicine Published 6 December 2018 Crick labsJulian DownwardFull details
Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors Authors (11) N Tsolakos TN Durrant T Chessa SM Suire D Oxley S KulkarniJulian Downward O Perisic RL Williams L Stephens PT Hawkins Proceedings of the National Academy of Sciences of the United States of America Published 15 November 2018 Crick labsJulian DownwardFull details
Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis Authors (24) Liudi Yao Franco Conforti Charlotte Hill Joseph Bell Leena Drawater Juanjuan Li[...] Luca Richeldi Paul Skipp Mark G Jones Donna E Davies Yihua Wang Cell Death and Differentiation Published 1 May 2019 Crick labsJulian DownwardFull details
AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons Authors (13) Marc PM Soutar Liam Kempthorne Shuichi Miyakawa Emily Annuario Daniela MelandriJasmine Harley[...]David Hancock Mark R CooksonJulian Downward Mark Carlton Hélène Plun-Favreau Scientific Reports Published 11 June 2018 Crick labsJulian DownwardFull details
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma Authors (12) Heike Miess Beatrice Dankworth Arvin M Gouw Mathias Rosenfeldt Werner SchmitzMing Jiang[...]Michael HowellJulian Downward Dean W Felsher Barrie Peck Almut Schulze Oncogene Published 4 October 2018 Crick labs/ facilitiesJulian DownwardHigh Throughput ScreeningFull details