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Breadcrumb Julian Downward Downward lab Oncogene Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Mass cytometry images of carcinogen induced lung tumours in mice. Toggle to view hero caption PublicationsYear published (-)2020 (7) Facet Year publishedResearch topicsChemical Biology & High Throughput (7)Gene Expression (7)Genetics & Genomics (7)Model Organisms (7)Signalling & Oncogenes (7)Tumour Biology (7)Genome Integrity & Repair (3)Structural Biology & Biophysics (3)Computational & Systems Biology (2)Human Biology & Physiology (2)Biochemistry & Proteomics (1)Cell Biology (1)Cell Cycle & Chromosomes (1)Developmental Biology (1)Stem Cells (1) Facet Research topicsPublication typeJournal article (7)Primary research (4)Method (2)Commentary (1) Facet Publication typeJournalWellcome Open Research (2)Cell (1)Cell Death and Disease (1)EMBO Molecular Medicine (1)Immunity (1)Nature Communications (1) Facet Journal Publications Displaying 1 - 7 of 7Last updated : 24 April 2024 02:22 WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer Authors (15) Ayse Ertay Huiquan Liu Dian Liu Ping Peng Charlotte Hill Hua Xiong[...]Michael Howell Paul Skipp Rob M EwingJulian Downward Yihua Wang Cell Death and Disease Published 21 November 2020 Crick labsJulian DownwardFull details Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer Authors (7)Davide ZecchinChristopher MooreFanis Michailidis Stuart HorswellSareena RanaMichael HowellJulian Downward EMBO Molecular Medicine Published 7 August 2020 Crick labs/ facilitiesJulian DownwardHigh Throughput ScreeningBioinformatics and BiostatisticsExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Evidence that STK19 is not an NRAS-dependent melanoma driver Authors (11)Marta Rodriguez Martinez Thierry BoissiéreMelvin Noe GonzalezKevin Litchfield Richard MitterJane WalkerSvend KjaerSoly IsmailJulian DownwardCharles SwantonJesper Svejstrup Cell Published 11 June 2020 Crick labs/ facilitiesCharles SwantonJesper SvejstrupJulian DownwardStructural BiologyBioinformatics and BiostatisticsProteomicsCell ServicesFull details Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets Authors (11) Rachel Cooley Neesha Kara Ning Sze Hui Jonathan TartChloe RoustanRoger GeorgeDavid Hancock Brock F Binkowski Keith V WoodSoly IsmailJulian Downward Wellcome Open Research Published 2 June 2020 Crick labs/ facilitiesJulian DownwardStructural BiologyCell ServicesBioinformatics and BiostatisticsAdvanced SequencingFull details IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche Authors (17) Sissy E Wamaitha Katarzyna J GrybelGregorio Alanis LobatoClaudia GerriSugako OgushiAfshan Mccarthy[...] Phil Snell Leila ChristieJulian DownwardJames TurnerKathy Niakan Nature Communications Published 7 February 2020 Crick labs/ facilitiesJames TurnerKathy NiakanJulian DownwardHuman Embryonic Stem CellScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsFull details Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets Authors (11) Rachel Cooley Neesha Kara Ning Sze Hui Jonathan TartChloe RoustanRoger GeorgeDavid Hancock Brock F Binkowski Keith V WoodSoly IsmailJulian Downward Wellcome Open Research Published 6 February 2020 Crick labs/ facilitiesJulian DownwardStructural BiologyFull details Mutant KRAS at the heart of tumor immune evasion Authors (2)Febe VanMaldegemJulian Downward Immunity Published 14 January 2020 Crick labsJulian DownwardFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer Authors (15) Ayse Ertay Huiquan Liu Dian Liu Ping Peng Charlotte Hill Hua Xiong[...]Michael Howell Paul Skipp Rob M EwingJulian Downward Yihua Wang Cell Death and Disease Published 21 November 2020 Crick labsJulian DownwardFull details
Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer Authors (7)Davide ZecchinChristopher MooreFanis Michailidis Stuart HorswellSareena RanaMichael HowellJulian Downward EMBO Molecular Medicine Published 7 August 2020 Crick labs/ facilitiesJulian DownwardHigh Throughput ScreeningBioinformatics and BiostatisticsExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Evidence that STK19 is not an NRAS-dependent melanoma driver Authors (11)Marta Rodriguez Martinez Thierry BoissiéreMelvin Noe GonzalezKevin Litchfield Richard MitterJane WalkerSvend KjaerSoly IsmailJulian DownwardCharles SwantonJesper Svejstrup Cell Published 11 June 2020 Crick labs/ facilitiesCharles SwantonJesper SvejstrupJulian DownwardStructural BiologyBioinformatics and BiostatisticsProteomicsCell ServicesFull details
Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets Authors (11) Rachel Cooley Neesha Kara Ning Sze Hui Jonathan TartChloe RoustanRoger GeorgeDavid Hancock Brock F Binkowski Keith V WoodSoly IsmailJulian Downward Wellcome Open Research Published 2 June 2020 Crick labs/ facilitiesJulian DownwardStructural BiologyCell ServicesBioinformatics and BiostatisticsAdvanced SequencingFull details
IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche Authors (17) Sissy E Wamaitha Katarzyna J GrybelGregorio Alanis LobatoClaudia GerriSugako OgushiAfshan Mccarthy[...] Phil Snell Leila ChristieJulian DownwardJames TurnerKathy Niakan Nature Communications Published 7 February 2020 Crick labs/ facilitiesJames TurnerKathy NiakanJulian DownwardHuman Embryonic Stem CellScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsFull details
Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets Authors (11) Rachel Cooley Neesha Kara Ning Sze Hui Jonathan TartChloe RoustanRoger GeorgeDavid Hancock Brock F Binkowski Keith V WoodSoly IsmailJulian Downward Wellcome Open Research Published 6 February 2020 Crick labs/ facilitiesJulian DownwardStructural BiologyFull details
Mutant KRAS at the heart of tumor immune evasion Authors (2)Febe VanMaldegemJulian Downward Immunity Published 14 January 2020 Crick labsJulian DownwardFull details