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Breadcrumb Julian Downward Downward lab Oncogene Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Mass cytometry images of carcinogen induced lung tumours in mice. Toggle to view hero caption PublicationsYear published (-)2023 (9) Facet Year publishedResearch topicsGene Expression (9)Genetics & Genomics (9)Model Organisms (9)Tumour Biology (9)Chemical Biology & High Throughput (8)Signalling & Oncogenes (8)Cell Biology (4)Cell Cycle & Chromosomes (4)Computational & Systems Biology (4)Genome Integrity & Repair (4)Human Biology & Physiology (3)Immunology (3)Stem Cells (3)Biochemistry & Proteomics (1)Infectious Disease (1)Structural Biology & Biophysics (1) Facet Research topicsPublication typeJournal article (9)Primary research (7)Obituary (1)Review (1) Facet Publication typeJournalNature (3)Biochemical Journal (1)Clinical cancer research (1)Genes and Diseases (1)Nature Communications (1)Nature Genetics (1)Scientific Reports (1) Facet Journal Publications Displaying 1 - 9 of 9Last updated : 24 April 2024 03:41 The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance Authors (85)Deborah Caswell Philippe Gui Manasi K Mayekar Emily K Law Oriol Pich Chris Bailey[...] Nnennaya Kanu Reuben S HarrisJulian Downward Trever G BivonaCharles Swanton Nature Genetics Published 1 January 2024 Crick labs/ facilitiesKaren VousdenCharles SwantonJulian DownwardExperimental HistopathologyBiological Research FacilityFull details Michael D. Waterfield Authors (3)Julian DownwardPeter Parker Bart Vanhaesebroeck Biochemical Journal Published 27 September 2023 Crick labsPeter ParkerJulian DownwardFull details Facts and hopes on RAS inhibitors and cancer immunotherapy Authors (3)Jesse BoumelhaMiriam Molina ArcasJulian Downward Clinical cancer research Published 15 December 2023 Crick labsJulian DownwardFull details LKB1 depletion-mediated epithelial–mesenchymal transition induces fibroblast activation in lung fibrosis Authors (14) Zijian Xu Elizabeth R Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani[...]Julian Downward Rob M Ewing Donna E Davies Mark G Jones Yihua Wang Genes and Diseases Published 1 May 2024 Crick labsJulian DownwardFull details Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4 Authors (40) J Chauhan M Grandits LCGF Palhares S Mele M Nakamura J López-Abente[...] P Karagiannis KE Lacy J Spicer SN Karagiannis HJ Bax Nature Communications Published 25 April 2023 Crick labsJulian DownwardFull details Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details Genomic-transcriptomic evolution in lung cancer and metastasis Authors (47) Carlos Martínez-Ruiz James RM Black Clare Puttick Mark S HillJonas DemeulemeesterElizabeth Larose Cadieux[...] Peter Van Loo Mariam Jamal-Hanjani TRACERx Consortium Charles Swanton Nicholas McGranahan Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α Authors (18)Soly Ismail Stephen R MartinRoger GeorgeFrankie HoughtonGeoff KellyRaphael Chaleil[...] Ning Sze HuiMiriam Molina ArcasDavid Hancock Ali TavassoliJulian Downward Scientific Reports Published 2 February 2023 Crick labs/ facilitiesJulian DownwardPaul BatesStructural BiologyMRC Biomedical NMR CentreFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance Authors (85)Deborah Caswell Philippe Gui Manasi K Mayekar Emily K Law Oriol Pich Chris Bailey[...] Nnennaya Kanu Reuben S HarrisJulian Downward Trever G BivonaCharles Swanton Nature Genetics Published 1 January 2024 Crick labs/ facilitiesKaren VousdenCharles SwantonJulian DownwardExperimental HistopathologyBiological Research FacilityFull details
Michael D. Waterfield Authors (3)Julian DownwardPeter Parker Bart Vanhaesebroeck Biochemical Journal Published 27 September 2023 Crick labsPeter ParkerJulian DownwardFull details
Facts and hopes on RAS inhibitors and cancer immunotherapy Authors (3)Jesse BoumelhaMiriam Molina ArcasJulian Downward Clinical cancer research Published 15 December 2023 Crick labsJulian DownwardFull details
LKB1 depletion-mediated epithelial–mesenchymal transition induces fibroblast activation in lung fibrosis Authors (14) Zijian Xu Elizabeth R Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani[...]Julian Downward Rob M Ewing Donna E Davies Mark G Jones Yihua Wang Genes and Diseases Published 1 May 2024 Crick labsJulian DownwardFull details
Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4 Authors (40) J Chauhan M Grandits LCGF Palhares S Mele M Nakamura J López-Abente[...] P Karagiannis KE Lacy J Spicer SN Karagiannis HJ Bax Nature Communications Published 25 April 2023 Crick labsJulian DownwardFull details
Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details
Genomic-transcriptomic evolution in lung cancer and metastasis Authors (47) Carlos Martínez-Ruiz James RM Black Clare Puttick Mark S HillJonas DemeulemeesterElizabeth Larose Cadieux[...] Peter Van Loo Mariam Jamal-Hanjani TRACERx Consortium Charles Swanton Nicholas McGranahan Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details
Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α Authors (18)Soly Ismail Stephen R MartinRoger GeorgeFrankie HoughtonGeoff KellyRaphael Chaleil[...] Ning Sze HuiMiriam Molina ArcasDavid Hancock Ali TavassoliJulian Downward Scientific Reports Published 2 February 2023 Crick labs/ facilitiesJulian DownwardPaul BatesStructural BiologyMRC Biomedical NMR CentreFull details