Publications

Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry

Authors (18)

Nature Communications

Published 8 October 2021

Crick labs/ facilities

Full details

Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis

Authors (19)

Liudi Yao
Yilu Zhou
Juanjuan Li
Leanne Wickens
Franco Conforti
Anna Rattu
[...]
Luca Richeldi
Paul Skipp
Donna E Davies
Mark G Jones
Yihua Wang

Journal of Biological Chemistry

Published 1 September 2021

Crick labs

Julian Downward

Full details

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer

Authors (43)

Stelios Chrysostomou
Rajat Roy
Filippo Prischi
Lucksamon Thamlikitkul
Kathryn L Chapman
Uwais Mufti
[...]
Julian Downward
Mark Skehel
Maruf MU Ali
Michael J Seckl
Olivier E Pardo

Science Translational Medicine

Published 14 July 2021

Crick labs

Julian Downward

Full details

JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer

Authors (13)

Josue Ruiz
Linxiang Lan
Markus Elmar Diefenbacher
Eva Madi Riising
Clive Da Costa
Atanu Chakraborty
[...]
Gavin Kelly
Jean-Pierre David
Emma Nye
Julian Downward
Axel Behrens

JCI insight

Published 8 July 2021

Crick labs/ facilities

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Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype

Authors (46)

Satyamaanasa Polubothu
Davide Zecchin
Lara Al-Olabi
Daniël A Lionarons
Mark Harland
Stuart Horswell
[...]
Gudrun E Moore
Wei-Li Di
Julia Newton-Bishop
Julian Downward
Veronica Kinsler

Genetics in Medicine

Published 1 September 2021

Crick labs/ facilities

Full details

Drugging the undruggable: Advances on RAS targeting in cancer

Authors (3)

Genes (Basel)

Published 10 June 2021

Crick labs

Julian Downward

Full details

Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

Authors (13)

Tereza Vaclova
Ursula Grazini
Lewis Ward
Daniel O'Neill
Aleksandra Markovets
Xiangning Huang
[...]
Kenneth S Thress
Paul D Smith
J Carl Barrett
Julian Downward
Elza C de Bruin

Nature Communications

Published 19 March 2021

Crick labs

Julian Downward

Full details

Quantitative proteomic analysis in alveolar type II cells reveals the different capacities of RAS and TGF-β to induce epithelial-mesenchymal transition

Authors (11)

Yilu Zhou
Charlotte Hill
Liudi Yao
Juanjuan Li
David Hancock
Julian Downward
Mark G Jones
Donna E Davies
Rob M Ewing
Paul Skipp
Yihua Wang

Frontiers in Molecular Biosciences

Published 19 March 2021

Crick labs

Julian Downward

Full details

WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer

Authors (15)

Ayse Ertay
Huiquan Liu
Dian Liu
Ping Peng
Charlotte Hill
Hua Xiong
[...]
Michael Howell
Paul Skipp
Rob M Ewing
Julian Downward
Yihua Wang

Cell Death and Disease

Published 21 November 2020

Crick labs

Julian Downward

Full details

Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer

Authors (7)

EMBO Molecular Medicine

Published 7 August 2020

Crick labs/ facilities

Full details

Evidence that STK19 is not an NRAS-dependent melanoma driver

Authors (11)

Cell

Published 11 June 2020

Crick labs/ facilities

Full details

Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets

Authors (11)

Rachel Cooley
Neesha Kara
Ning Sze Hui
Jonathan Tart
Chloe Roustan
Roger George
David Hancock
Brock F Binkowski
Keith V Wood
Soly Ismail
Julian Downward

Wellcome Open Research

Published 2 June 2020

Crick labs/ facilities

Full details

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

Authors (17)

Sissy E Wamaitha
Katarzyna J Grybel
Gregorio Alanis Lobato
Claudia Gerri
Sugako Ogushi
Afshan Mccarthy
[...]
Phil Snell
Leila Christie
Julian Downward
James Turner
Kathy Niakan

Nature Communications

Published 7 February 2020

Crick labs/ facilities

Full details

Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets

Authors (11)

Rachel Cooley
Neesha Kara
Ning Sze Hui
Jonathan Tart
Chloe Roustan
Roger George
David Hancock
Brock F Binkowski
Keith V Wood
Soly Ismail
Julian Downward

Wellcome Open Research

Published 6 February 2020

Crick labs/ facilities

Full details

Mutant KRAS at the heart of tumor immune evasion

Authors (2)

Immunity

Published 14 January 2020

Crick labs

Julian Downward

Full details

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer

Authors (12)

Miriam Molina Arcas
Christopher Moore
Sareena Rana
Febe VanMaldegem
Edurne Mugarza
Pablo Romero-Clavijo
[...]
Stuart Horswell
Lian-Sheng Li
Matthew R Janes
David Hancock
Julian Downward

Science Translational Medicine

Published 18 September 2019

Crick labs/ facilities

Full details

ATMIN is a tumor suppressor gene in lung adenocarcinoma

Authors (10)

Hanna Foster
Josue Ruiz
Christopher Moore
Gordon WH Stamp
Emma Nye
Ningning Li
Yihang Pan
Yulong He
Julian Downward
Axel Behrens

Cancer Research

Published 15 October 2019

Crick labs/ facilities

Full details

Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

Authors (20)

Charlotte Hill
Juanjuan Li
Dian Liu
Franco Conforti
Christopher J Brereton
Liudi Yao
[...]
Luca Richeldi
Xin Lu
Donna E Davies
Mark G Jones
Yihua Wang

Cell Death and Disease

Published 7 August 2019

Crick labs

Julian Downward

Full details

RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

Authors (17)

Cancer Cell

Published 8 July 2019

Crick labs/ facilities

Full details

SGLT1 is required for the survival of triple-negative breast cancer cells via potentiation of EGFR activity

Authors (14)

Huiquan Liu
Ayse Ertay
Ping Peng
Juanjuan Li
Dian Liu
Hua Xiong
[...]
Xianglin Yuan
Wei-Chien Huang
Rob M Ewing
Julian Downward
Yihua Wang

Molecular Oncology

Published 1 September 2019

Crick labs

Julian Downward

Full details

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Publications

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Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry

Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer

JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer

Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype

Drugging the undruggable: Advances on RAS targeting in cancer

Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

Quantitative proteomic analysis in alveolar type II cells reveals the different capacities of RAS and TGF-β to induce epithelial-mesenchymal transition

WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer

Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer

Evidence that STK19 is not an NRAS-dependent melanoma driver

Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets

Mutant KRAS at the heart of tumor immune evasion

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer

ATMIN is a tumor suppressor gene in lung adenocarcinoma

Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

SGLT1 is required for the survival of triple-negative breast cancer cells via potentiation of EGFR activity

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