Publications

RAS mutation status and bortezomib therapy for relapsed multiple myeloma

Authors (9)

Dean Smith
Elena Armenteros
Laura Percy
Madhu Kumar
Anna Lach
Gaelle Herledan
Matthew Stubbs
Julian Downward
Kwee Yong

British Journal of Haematology

Published 1 June 2015

Crick labs

Julian Downward

Full details

Overview of KRAS-driven genetically engineered mouse models of non-small cell lung cancer

Authors (2)

Clare Sheridan
Julian Downward

Current Protocols in Pharmacology

Published 1 January 2015

Crick labs

Julian Downward

Full details

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1

Authors (24)

Yihua Wang
Fangfang Bu
Christophe Royer
Sébastien Serres
James R Larkin
Manuel Sarmiento Soto
[...]
Robert D Goldin
Jian Zhao
Xin Tong
Yajun Guo
Xin Lu

Nature Cell Biology

Published 1 November 2014

Crick labs

Julian Downward

Full details

Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer

Authors (9)

David Endesfelder
Rebecca A Burrell
Nnennaya Kanu
Nicholas McGranahan
Michael Howell
Peter Parker
Julian Downward
Charles Swanton
Maik Kschischo

Cancer Research

Published 1 September 2014

Crick labs/ facilities

Full details

Guidelines for the use of cell lines in biomedical research

Authors (12)

RJ Geraghty
A Capes-Davis
JM Davis
Julian Downward
RI Freshney
I Knezevic
[...]
JRW Masters
J Meredith
GN Stacey
P Thraves
M Vias

British Journal of Cancer

Published 12 August 2014

Crick labs

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RAS interaction with PI3K p110α is required for tumor-induced angiogenesis

Authors (7)

Miguel Manuel Murillo
Santiago Zelenay
Emma Nye
Esther Castellano
François Lassailly
Gordon Stamp
Julian Downward

Journal of Clinical Investigation

Published 1 August 2014

Crick labs/ facilities

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Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer

Authors (20)

Elza C de Bruin
Catherine Cowell
Patricia H Warne
Ming Jiang
Rebecca E Saunders
Mary Ann Melnick
[...]
Harold Varmus
René Bernards
Egbert F Smit
Katerina Politi
Julian Downward

Cancer Discovery

Published 1 May 2014

Crick labs/ facilities

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Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids

Authors (13)

Mark Linch
Marta Sanz-Garcia
Carine Rosse
Philippe Riou
Nick Peel
Chris D Madsen
[...]
Asim Khwaja
Christian Dillon
Jon Roffey
Angus JM Cameron
Peter Parker

Carcinogenesis

Published 1 February 2014

Crick labs

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RAS's cloak of invincibility slips at last?

Authors (1)

Julian Downward

Cancer Cell

Published 13 January 2014

Crick labs

Julian Downward

Full details

Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance

Authors (13)

Esther Castellano
Clare Sheridan
May Zaw Thin
Emma Nye
Bradley Spencer-Dene
Markus E Diefenbacher
[...]
Miguel M Murillo
Eva Gronroos
François Lassailly
Gordon Stamp
Julian Downward

Cancer Cell

Published 11 November 2013

Crick labs/ facilities

Full details

SnapShot: Class I PI3K isoform signaling

Authors (2)

Ralph Fritsch
Julian Downward

Cell

Published 15 August 2013

Crick labs

Julian Downward

Full details

PI3K pathway dependencies in endometrioid endometrial cancer cell lines

Authors (5)

Britta Weigelt
Patricia H Warne
Maryou B Lambros
Jorge S Reis-Filho
Julian Downward

Clinical cancer research

Published 1 July 2013

Crick labs/ facilities

Full details

RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms

Authors (9)

Ralph Fritsch
Inge de Krijger
Kornelia Fritsch
Roger George
Beth Reason
Madhu S Kumar
Markus Diefenbacher
Gordon Stamp
Julian Downward

Cell

Published 23 May 2013

Crick labs/ facilities

Full details

Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer

Authors (5)

Miriam Molina Arcas
David Hancock
Clare Sheridan
Madhu S Kumar
Julian Downward

Cancer Discovery

Published 1 May 2013

Crick labs

Julian Downward

Full details

Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration

Authors (8)

Gábor Bögel
Annamária Gujdár
Miklós Geiszt
Árpád Lányi
Anna Fekete
Szabolcs Sipeki
Julian Downward
László Buday

Journal of Biological Chemistry

Published 7 September 2012

Crick labs

Julian Downward

Full details

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

Authors (11)

Michael Steckel
Miriam Molina Arcas
Britta Weigelt
Michaela Marani
Patricia H Warne
Hanna Kuznetsov
Gavin Kelly
Becky Saunders
Michael Howell
Julian Downward
David Hancock

Cell Research

Published 1 August 2012

Crick labs/ facilities

Full details

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

Authors (13)

Madhu S Kumar
David Hancock
Miriam Molina Arcas
Michael Steckel
Phil East
Markus Diefenbacher
[...]
Nik Matthews
Emma Nye
Gordon Stamp
Axel Behrens
Julian Downward

Cell

Published 27 April 2012

Crick labs/ facilities

Full details

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing

Authors (30)

Marco Gerlinger
Andrew Rowan
Stuart Horswell
James Larkin
David Endesfelder
Eva Gronroos
[...]
Martin Gore
Zoltan Szallasi
Julian Downward
P Andrew Futreal
Charles Swanton

New England Journal of Medicine

Published 8 March 2012

Crick labs/ facilities

Full details

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

Authors (20)

Alvin Lee
Rebecca Roylance
Jil Sander
Patricia Gorman
David Endesfelder
Maik Kschischo
[...]
Valerie Speirs
Andrew M Hanby
Julian Downward
Sharon Tooze
Charles Swanton

Journal of Pathology

Published 1 February 2012

Crick labs/ facilities

Full details

How to fool a wonder drug: truncate and dimerize

Authors (2)

Cancer Cell

Published 17 January 2012

Crick labs

Julian Downward

Full details

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Publications

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Journal

RAS mutation status and bortezomib therapy for relapsed multiple myeloma

Overview of KRAS-driven genetically engineered mouse models of non-small cell lung cancer

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1

Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer

Guidelines for the use of cell lines in biomedical research

RAS interaction with PI3K p110α is required for tumor-induced angiogenesis

Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer

Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids

RAS's cloak of invincibility slips at last?

Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance

SnapShot: Class I PI3K isoform signaling

PI3K pathway dependencies in endometrioid endometrial cancer cell lines

RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms

Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer

Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

How to fool a wonder drug: truncate and dimerize

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