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Breadcrumb Julian Downward Downward lab Oncogene Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Mass cytometry images of carcinogen induced lung tumours in mice. 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97 of 97Last updated : 28 March 2024 03:34 Genomic determinants of PI3K pathway inhibitor response in cancer Authors (2) Britta WeigeltJulian Downward Frontiers in Oncology Published 1 January 2012 Crick labsJulian DownwardFull details Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells Authors (2) Almut SchulzeJulian Downward Molecular Cell Published 23 December 2011 Crick labsJulian DownwardFull details Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer Authors (15) Rebecca Roylance David Endesfelder Patricia Gorman Rebecca A Burrell Jil Sander Ian Tomlinson[...] Aron C EklundJulian Downward Maik Kschischo Zoltan SzallasiCharles Swanton Cancer Epidemiology, Biomarkers & Prevention Published 1 October 2011 Crick labsCharles SwantonJulian DownwardFull details An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis Authors (17) R Lara FA Mauri H Taylor R Derua A Shia C Gray[...] J Lamb D ZichaJulian Downward MJ Seckl OE Pardo Oncogene Published 11 August 2011 Crick labs/ facilitiesJulian DownwardPaul BatesLight MicroscopyFull details PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs Authors (3) B Weigelt PH WarneJulian Downward Oncogene Published 21 July 2011 Crick labsJulian DownwardFull details Chromosomal instability confers intrinsic multidrug resistance Authors (12)Alvin Lee David EndesfelderAndrew Rowan Axel WaltherNicolai Birkbak P Andrew Futreal[...] Zoltan Szallasi Ian PM TomlinsonMichael Howell Maik KschischoCharles Swanton Cancer Research Published 1 March 2011 Crick labs/ facilitiesCharles SwantonJulian DownwardHigh Throughput ScreeningFull details RAS interaction with PI3K: more than just another effector pathway Authors (2) Esther CastellanoJulian Downward Genes & Cancer Published 1 March 2011 Crick labsJulian DownwardFull details Targeting RAF: trials and tribulations Authors (1)Julian Downward Nature Medicine Published 1 March 2011 Crick labsJulian DownwardFull details PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading Authors (8) Kathrin S Zeller Olof Idevall-Hagren Anne Stefansson Teet Velling Shaun P JacksonJulian Downward Anders Tengholm Staffan Johansson Cellular Signalling Published 1 December 2010 Crick labsJulian DownwardFull details Role of RAS in the regulation of PI 3-kinase Authors (2) E CastellanoJulian Downward Current Topics in Microbiology and Immunology Published 1 December 2010 Crick labsJulian DownwardFull details Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells Authors (7) Y Wang VN Ngo M Marani Y Yang G Wright LM StaudtJulian Downward Oncogene Published 19 August 2010 Crick labsJulian DownwardFull details Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor Authors (7) Daniela Alfano Giuseppina Votta Almut SchulzeJulian Downward Mario Caputi Maria Patrizia Stoppelli Ingram Iaccarino Molecular and Cellular Biology Published 1 April 2010 Crick labsJulian DownwardFull details Rictor is a novel target of p70 S6 kinase-1 Authors (5) C Treins PH Warne MA Magnuson M PendeJulian Downward Oncogene Published 18 February 2010 Crick labsJulian DownwardFull details A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1 Authors (10) Megan Cully Alice Genevet Patricia Warne Caroline Treins Tao Liu Julie Bastien Buzz BaumNicolas Tapon Sally J LeeversJulian Downward Molecular and Cellular Biology Published 1 January 2010 Crick labsNic TaponJulian DownwardFull details Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells Authors (7) Maria Teresa Vento Valeria Zazzu Alessia Loffreda Justin R CrossJulian Downward Maria Patrizia Stoppelli Ingram Iaccarino PLOS ONE Published 1 January 2010 Crick labsJulian DownwardFull details Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets Authors (23)Charles Swanton James M Larkin Marco Gerlinger Aron C EklundMichael Howell Gordon Stamp[...] Hansjuergen Volkmer Luisella Toschi Barbara Nicke Marlene Beck Zoltan Szallasi Genome Medicine Published 1 January 2010 Crick labs/ facilitiesCharles SwantonJulian DownwardHigh Throughput ScreeningExperimental HistopathologyFull details Role of RAS in the regulation of PI 3-kinase Authors (2) Esther CastellanoJulian Downward Current Topics in Microbiology and Immunology Published 1 January 2010 Crick labsJulian DownwardFull details Pagination First page First Previous page Previous Page 1 Page 2 Page 3 Page 4 Current page 5 Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Genomic determinants of PI3K pathway inhibitor response in cancer Authors (2) Britta WeigeltJulian Downward Frontiers in Oncology Published 1 January 2012 Crick labsJulian DownwardFull details
Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells Authors (2) Almut SchulzeJulian Downward Molecular Cell Published 23 December 2011 Crick labsJulian DownwardFull details
Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer Authors (15) Rebecca Roylance David Endesfelder Patricia Gorman Rebecca A Burrell Jil Sander Ian Tomlinson[...] Aron C EklundJulian Downward Maik Kschischo Zoltan SzallasiCharles Swanton Cancer Epidemiology, Biomarkers & Prevention Published 1 October 2011 Crick labsCharles SwantonJulian DownwardFull details
An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis Authors (17) R Lara FA Mauri H Taylor R Derua A Shia C Gray[...] J Lamb D ZichaJulian Downward MJ Seckl OE Pardo Oncogene Published 11 August 2011 Crick labs/ facilitiesJulian DownwardPaul BatesLight MicroscopyFull details
PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs Authors (3) B Weigelt PH WarneJulian Downward Oncogene Published 21 July 2011 Crick labsJulian DownwardFull details
Chromosomal instability confers intrinsic multidrug resistance Authors (12)Alvin Lee David EndesfelderAndrew Rowan Axel WaltherNicolai Birkbak P Andrew Futreal[...] Zoltan Szallasi Ian PM TomlinsonMichael Howell Maik KschischoCharles Swanton Cancer Research Published 1 March 2011 Crick labs/ facilitiesCharles SwantonJulian DownwardHigh Throughput ScreeningFull details
RAS interaction with PI3K: more than just another effector pathway Authors (2) Esther CastellanoJulian Downward Genes & Cancer Published 1 March 2011 Crick labsJulian DownwardFull details
Targeting RAF: trials and tribulations Authors (1)Julian Downward Nature Medicine Published 1 March 2011 Crick labsJulian DownwardFull details
PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading Authors (8) Kathrin S Zeller Olof Idevall-Hagren Anne Stefansson Teet Velling Shaun P JacksonJulian Downward Anders Tengholm Staffan Johansson Cellular Signalling Published 1 December 2010 Crick labsJulian DownwardFull details
Role of RAS in the regulation of PI 3-kinase Authors (2) E CastellanoJulian Downward Current Topics in Microbiology and Immunology Published 1 December 2010 Crick labsJulian DownwardFull details
Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells Authors (7) Y Wang VN Ngo M Marani Y Yang G Wright LM StaudtJulian Downward Oncogene Published 19 August 2010 Crick labsJulian DownwardFull details
Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor Authors (7) Daniela Alfano Giuseppina Votta Almut SchulzeJulian Downward Mario Caputi Maria Patrizia Stoppelli Ingram Iaccarino Molecular and Cellular Biology Published 1 April 2010 Crick labsJulian DownwardFull details
Rictor is a novel target of p70 S6 kinase-1 Authors (5) C Treins PH Warne MA Magnuson M PendeJulian Downward Oncogene Published 18 February 2010 Crick labsJulian DownwardFull details
A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1 Authors (10) Megan Cully Alice Genevet Patricia Warne Caroline Treins Tao Liu Julie Bastien Buzz BaumNicolas Tapon Sally J LeeversJulian Downward Molecular and Cellular Biology Published 1 January 2010 Crick labsNic TaponJulian DownwardFull details
Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells Authors (7) Maria Teresa Vento Valeria Zazzu Alessia Loffreda Justin R CrossJulian Downward Maria Patrizia Stoppelli Ingram Iaccarino PLOS ONE Published 1 January 2010 Crick labsJulian DownwardFull details
Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets Authors (23)Charles Swanton James M Larkin Marco Gerlinger Aron C EklundMichael Howell Gordon Stamp[...] Hansjuergen Volkmer Luisella Toschi Barbara Nicke Marlene Beck Zoltan Szallasi Genome Medicine Published 1 January 2010 Crick labs/ facilitiesCharles SwantonJulian DownwardHigh Throughput ScreeningExperimental HistopathologyFull details
Role of RAS in the regulation of PI 3-kinase Authors (2) Esther CastellanoJulian Downward Current Topics in Microbiology and Immunology Published 1 January 2010 Crick labsJulian DownwardFull details