Publications

Mutant p53 in cell-cell interactions

Authors (3)

Steven Pilley
Tristan A Rodriguez
Karen Vousden

Genes and Development

Published 1 April 2021

Crick labs

Karen Vousden

Full details

Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

Authors (16)

Nicholas Jones
Julianna Blagih
Fabio Zani
April Rees
David G Hill
Benjamin J Jenkins
[...]
Gareth W Jones
David K Finlay
Karen Vousden
Emma E Vincent
Catherine A Thornton

Nature Communications

Published 22 February 2021

Crick labs/ facilities

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Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

Authors (9)

Cell Reports

Published 16 February 2021

Crick labs/ facilities

Full details

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

Authors (23)

Mylene Tajan
Marc Hennequart
Eric Cheung
Fabio Zani
Andreas K Hock
Nathalie Legrave
[...]
Adam Friedman
Mark Manfredi
Karen Blyth
Owen J Sansom
Karen Vousden

Nature Communications

Published 14 January 2021

Crick labs/ facilities

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Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice

Authors (12)

Tim Humpton
Koji Nomura
Julia Weber
Helge M Magnussen
Andreas K Hock
Colin Nixon
[...]
David Stevenson
Danny T Huang
Douglas Strathdee
Karen Blyth
Karen Vousden

Genes and Development

Published 1 January 2021

Crick labs

Karen Vousden

Full details

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

Dietary approaches to cancer therapy

Authors (2)

Cancer Cell

Published 8 June 2020

Crick labs

Karen Vousden

Full details

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

Authors (12)

Helge M Magnussen
Syed F Ahmed
Gary J Sibbet
Ventzislava A Hristova
Koji Nomura
Andreas K Hock
[...]
Andrew G Jamieson
David Fushman
Karen Vousden
Allan M Weissman
Danny T Huang

Nature Communications

Published 29 April 2020

Crick labs

Karen Vousden

Full details

p53, cancer and the immune response

Authors (3)

Journal of Cell Science

Published 6 March 2020

Crick labs

Karen Vousden

Full details

Dynamic ROS control by TIGAR regulates the initiation and progression of pancreatic cancer

Authors (7)

Eric Cheung
Gina M DeNicola
Colin Nixon
Karen Blyth
Christiaan Labuschagne
David A Tuveson
Karen Vousden

Cancer Cell

Published 10 February 2020

Crick labs

Karen Vousden

Full details

Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses

Authors (16)

Cell Reports

Published 14 January 2020

Crick labs/ facilities

Full details

A roadmap for the next decade in cancer research

Authors (10)

René Bernards
Elizabeth Jaffee
Johanna A Joyce
Scott W Lowe
Elaine R Mardis
Sean J Morrison
Kornelia Polyak
Cynthia L Sears
Karen Vousden
Zemin Zhang

Nature Cancer

Published 13 January 2020

Crick labs

Karen Vousden

Full details

Cell clustering promotes a metabolic switch that supports metastatic colonization

Authors (5)

Cell Metabolism

Published 1 October 2019

Crick labs/ facilities

Full details

Taking up the reins of power: metabolic functions of p53

Authors (2)

Journal of molecular cell biology

Published 15 August 2019

Crick labs

Karen Vousden

Full details

Oncogenic KRAS induces NIX-mediated mitophagy to promote pancreatic cancer

Authors (17)

Tim Humpton
Brinda Alagesan
Gina M DeNicola
Dan Lu
Georgi N Yordanov
Carl S Leonhardt
[...]
Pedro A Perez-Mancera
Michael P Murphy
Gerard Evan
Karen Vousden
David A Tuveson

Cancer Discovery

Published 1 September 2019

Crick labs

Full details

Brexit negotiations: what is next for science?

Authors (1)

Karen Vousden

EMBO Reports

Published 15 March 2019

Crick labs

Karen Vousden

Full details

Use of 13C315N1-serine or 13C515N1-methionine for studying methylation dynamics in cancer cell metabolism and epigenetics

Authors (4)

Alice C Newman
Christiaan Labuschagne
Karen Vousden
Oliver DK Maddocks

Methods in Molecular Biology

Published 7 February 2019

Crick labs

Karen Vousden

Full details

Direct estimation of metabolic flux by heavy isotope labeling simultaneous with pathway inhibition: Metabolic flux inhibition assay

Authors (4)

Tong Zhang
Christiaan Labuschagne
Karen Vousden
Oliver DK Maddocks

Methods in Molecular Biology

Published 1 January 2019

Crick labs

Karen Vousden

Full details

p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant

Authors (4)

Tim Humpton
Andreas K Hock
Oliver DK Maddocks
Karen Vousden

Cancer & Metabolism

Published 3 December 2018

Crick labs

Karen Vousden

Full details

A role for p53 in the adaptation to glutamine starvation through the expression of SLC1A3

Authors (9)

Mylene Tajan
Andreas K Hock
Julianna Blagih
Neil A Robertson
Christiaan Labuschagne
Flore Kruiswijk
Tim Humpton
Peter D Adams
Karen Vousden

Cell Metabolism

Published 6 November 2018

Crick labs/ facilities

Full details

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: Publications

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Publications

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Journal

Mutant p53 in cell-cell interactions

Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Dietary approaches to cancer therapy

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

p53, cancer and the immune response

Dynamic ROS control by TIGAR regulates the initiation and progression of pancreatic cancer

Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses

A roadmap for the next decade in cancer research

Cell clustering promotes a metabolic switch that supports metastatic colonization

Taking up the reins of power: metabolic functions of p53

Oncogenic KRAS induces NIX-mediated mitophagy to promote pancreatic cancer

Brexit negotiations: what is next for science?

Use of 13C315N1-serine or 13C515N1-methionine for studying methylation dynamics in cancer cell metabolism and epigenetics

Direct estimation of metabolic flux by heavy isotope labeling simultaneous with pathway inhibition: Metabolic flux inhibition assay

p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant

A role for p53 in the adaptation to glutamine starvation through the expression of SLC1A3

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