Retroviruses cause severe diseases, including immunodeficiency and cancer. The human immunodeficiency virus (HIV) is the most widely known retrovirus due to its impact on human health. The latest figures (WHO/UNAIDS 2017) report that nearly 37 million people globally are living with HIV/AIDS.
Innovative therapeutics for retroviral diseases will hopefully arise from a better understanding of how retroviruses reproduce in the cell, how they interact with host cell factors and how they subvert the host innate and adaptive immune systems. The early stages of the retroviral life cycle are particularly attractive therapeutic targets, with several anti-retroviral drugs and cellular anti-viral factors inhibiting these steps. However, numerous events that occur during these stages are still poorly understood. The three main projects in our laboratory aim to characterise the molecular events that occur once a retrovirus has entered a cell in order to fully understand retroviral replication and provide potential ways in which to manipulate these processes for the benefit of human health.